Advances in Aptasensor Technology

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (1 April 2025) | Viewed by 2271

Special Issue Editor


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Guest Editor
College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Changde 415000, China
Interests: nanomaterials; functional nucleic acid; biosensing; cell imaging; drug delivery
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Special Issue Information

Dear Colleagues,

Nucleic acid aptamers refer to single-stranded oligonucleotides that can bind to target molecules with high affinity and specificity, obtained through in vitro screening of artificially synthesized DNA/RNA libraries using SELEX (systematic evolution of ligands by exponential enrichment) technology. As a novel molecular recognition element, nucleic acid aptamers have many advantages over antibodies, such as high affinity and specificity, a wider range of target molecules, easy synthesis, good stability, and ease of modification and labeling. Given these unparalleled advantages, nucleic acid aptamers have attracted widespread attention from both the scientific and industrial communities since their discovery, and have been frequently studied for the detection of various target molecules in recent years.

This Special Issue aims to publish a series of excellent, insightful, influential, and original research articles or reviews on the applications of aptasensors in various fields such as clinical diagnosis, food safety, and environmental monitoring. We hope that these papers will be widely read and have a significant impact in this field.

Dr. Songbai Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nucleic acid
  • aptamers
  • DNA/RNA
  • diagnosis

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Published Papers (1 paper)

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Review

22 pages, 2355 KiB  
Review
A Brief Review of Aptamer-Based Biosensors in Recent Years
by Wenjing Wang, Yumin He, Suxiang He, Lei Deng, Hui Wang, Zhong Cao, Zemeng Feng, Benhai Xiong and Yulong Yin
Biosensors 2025, 15(2), 120; https://doi.org/10.3390/bios15020120 - 18 Feb 2025
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Abstract
Aptamers have recently become novel probes for biosensors because of their good biocompatibility, strong specificity, and high sensitivity. Biosensors based on peptides or nucleic acid aptamers are used in implantable and wearable devices owing to their ease of synthesis and economic efficiency. Simultaneously, [...] Read more.
Aptamers have recently become novel probes for biosensors because of their good biocompatibility, strong specificity, and high sensitivity. Biosensors based on peptides or nucleic acid aptamers are used in implantable and wearable devices owing to their ease of synthesis and economic efficiency. Simultaneously, amphoteric ionic peptides are being explored as antifouling layers for biosensors resistant to interference from extraneous proteins in serum. Thus, this paper reviews recently developed aptamer-based biosensors and introduces peptide- and nucleic acid-based biosensors, while focusing on the three primary classes of biosensors: electrochemical sensors, fluorescent or colorimetric biosensors, and electroluminescent sensors. Furthermore, we summarize their general construction strategies, describe specific electrochemical sensors that use peptides as an antipollution layer, and elucidate their advantages. Full article
(This article belongs to the Special Issue Advances in Aptasensor Technology)
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