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Biosensors
Special Issues
The Emerging Techniques in Biosensors and Bioelectronics
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The Emerging Techniques in Biosensors and Bioelectronics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 1 November 2025 | Viewed by 3015

Special Issue Editor

Prof. Dr. Shunbo Li

E-Mail Website
Guest Editor
College of Optoelectronic Engineering, Chongqing University, Chongqing, China
Interests: microfluidics and nanofluidics; biosensors; SERS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors have become omnipresent in contemporary biomedical diagnostics. Their applications extend to diverse domains, encompassing point-of-care monitoring of treatment and disease progression, environmental surveillance, food quality control, drug discovery, forensics, and biomedical research. The development of biosensors involves the emerging of novel detection techniques, and their integration with high-affinity biomolecules facilitates the precise detection of a wide array of analytes. This Special Issue, entitled "Emerging Techniques in Biosensors and Bioelectronics: Selected Papers from the International Conference on Biosensors and Bioelectronics, 2024", aims to spotlight the latest advancements in biosensor research and their multifaceted applications across healthcare, environmental ecology, and food safety. We eagerly welcome submissions that showcase the forefront of developments in this research field. Topics may include, but are not limited to the following:

  1. Optical biosensors;
  2. Nanotechnology in biosensors;
  3. Flexible and wearable biosensors;
  4. Portable biosensors;
  5. Artificial intelligence (AI) in biosensing and analysis.

Prof. Dr. Shunbo Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • nanotechnology
  • micro/nanofluidics
  • wearable devices
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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12 pages, 14201 KiB  
Article
Development of Novel Surface-Enhanced Raman Spectroscopy-Based Biosensors by Controlling the Roughness of Gold/Alumina Platforms for Highly Sensitive Detection of Pyocyanin Secreted from Pseudomonas aeruginosa
by Waleed A. El-Said, Tamer S. Saleh, Abdullah Saad Al-Bogami, Mohmmad Younus Wani and Jeong-woo Choi
Biosensors 2024, 14(8), 399; https://doi.org/10.3390/bios14080399 - 19 Aug 2024
Cited by 1 | Viewed by 1571
Abstract
Pyocyanin is considered a maker of Pseudomonas aeruginosa (P. aeruginosa) infection. Pyocyanin is among the toxins released by the P. aeruginosa bacteria. Therefore, the development of a direct detection of PYO is crucial due to its importance. Among the different optical [...] Read more.
Pyocyanin is considered a maker of Pseudomonas aeruginosa (P. aeruginosa) infection. Pyocyanin is among the toxins released by the P. aeruginosa bacteria. Therefore, the development of a direct detection of PYO is crucial due to its importance. Among the different optical techniques, the Raman technique showed unique advantages because of its fingerprint data, no sample preparation, and high sensitivity besides its ease of use. Noble metal nanostructures were used to improve the Raman response based on the surface-enhanced Raman scattering (SERS) technique. Anodic metal oxide attracts much interest due to its unique morphology and applications. The porous metal structure provides a large surface area that could be used as a hard template for periodic nanostructure array fabrication. Porous shapes and sizes could be controlled by controlling the anodization parameters, including the anodization voltage, current, temperature, and time, besides the metal purity and the electrolyte type/concentration. The anodization of aluminum foil results in anodic aluminum oxide (AAO) formation with different roughness. Here, we will use the roughness as hotspot centers to enhance the Raman signals. Firstly, a thin film of gold was deposited to develop gold/alumina (Au/AAO) platforms and then applied as SERS-active surfaces. The morphology and roughness of the developed substrates were investigated using scanning electron microscopy (SEM) and atomic force microscopy (AFM) techniques. The Au/AAO substrates were used for monitoring pyocyanin secreted from Pseudomonas aeruginosa microorganisms based on the SERS technique. The results showed that the roughness degree affects the enhancement efficiency of this sensor. The high enhancement was obtained in the case of depositing a 30 nm layer of gold onto the second anodized substrates. The developed sensor showed high sensitivity toward pyocyanin with a limit of detection of 96 nM with a linear response over a dynamic range from 1 µM to 9 µM. Full article
(This article belongs to the Special Issue The Emerging Techniques in Biosensors and Bioelectronics)
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Review

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23 pages, 3730 KiB  
Review
SERS-Active Micro/Nanomachines for Biosensing
by Chenbing Li, Wenqing Zhang, Kai Zheng and Jianhe Guo
Biosensors 2025, 15(2), 115; https://doi.org/10.3390/bios15020115 - 16 Feb 2025
Viewed by 959
Abstract
Surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful noninvasive analytical technique with widespread applications in biochemical analysis and biomedical diagnostics. The need for highly sensitive, reproducible, and efficient detection of biomolecules in complex biological environments has driven significant advancements in SERS-based biosensing [...] Read more.
Surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful noninvasive analytical technique with widespread applications in biochemical analysis and biomedical diagnostics. The need for highly sensitive, reproducible, and efficient detection of biomolecules in complex biological environments has driven significant advancements in SERS-based biosensing platforms. In this context, micro/nanomachines (MNMs) have garnered attention as versatile SERS-active substrates due to their unique structural and motional characteristics at the micro- and nanoscale. This review explores the advantages of integrating MNMs with SERS for biosensing, discussing recent technological advances, various propulsion strategies, and their potential in a range of analytical applications. Full article
(This article belongs to the Special Issue The Emerging Techniques in Biosensors and Bioelectronics)
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