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Biosensors
Special Issues
Feature Papers of Biosensors
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Feature Papers of Biosensors

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 6121

Special Issue Editors

Prof. Dr. Jun-Jie Zhu

grade E-Mail Website
Guest Editor
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
Interests: electrochemical sensing; bioanalysis; bioimaging; nanoanalysis
Prof. Dr. Tingting Zheng

E-Mail Website
Guest Editor
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China
Interests: in-vitro diagnostic analysis based on semiconductor-enhanced Raman spectroscopy

Special Issue Information

Dear Colleagues,

As the Associate Editor of Biosensors, I am pleased to announce this Special Issue, entitled “Feature Papers of Biosensors”. This Special Issue aims to collect high-quality papers in the field of biosensors. We encourage researchers from various fields within the journal’s scope to contribute original research or review papers that highlight the latest developments in their research field, or to invite relevant experts and colleagues to do so. The relevant topics of this Special Issue include, but are not limited to, the following:

  • Biosensor-related materials;
  • Biorecognition elements (enzymes, antibodies, nucleic acids, molecularly imprinted polymers) in biosensors;
  • Biosensing interface construction;
  • Optical transducers, electrochemical transducers, mechanical transducers, and mass spectral transducers for biosensors;
  • Microfabrication and printing techniques in biosensors;
  • Wearable and implantable biosensors;

Development and application of biosensors in medicine, food industry, environmental monitoring, metabolism, and agriculture.

Prof. Dr. Jun-Jie Zhu
Prof. Dr. Tingting Zheng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensor
  • fluorescence
  • Raman
  • mechanical transducers
  • microfabrication
  • mass spectral transducers
  • wearable device

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

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Research

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12 pages, 2231 KiB  
Article
A Time-Resolved Fluorescent Microsphere Immunochromatographic Assay for Determination of Vitamin B12 in Infant Formula Milk Powder
by Qianqian Lu, Yongwei Feng, Qi Zhou, Ting Yang, Hua Kuang, Chuanlai Xu and Lingling Guo
Biosensors 2025, 15(2), 65; https://doi.org/10.3390/bios15020065 - 21 Jan 2025
Viewed by 990
Abstract
Vitamin B12 (VB12) is an important nutrient, and its quality control in food is crucial. In this study, based on the principle of specific recognition of target analyte by monoclonal antibodies (mAbs), a time-resolved fluorescent microsphere immunochromatographic assay (TRFM-ICA) was developed to detect [...] Read more.
Vitamin B12 (VB12) is an important nutrient, and its quality control in food is crucial. In this study, based on the principle of specific recognition of target analyte by monoclonal antibodies (mAbs), a time-resolved fluorescent microsphere immunochromatographic assay (TRFM-ICA) was developed to detect the content of VB12 in infant formula milk powder. First, the performance of the anti-VB12 mAb was evaluated, revealing a half-maximal inhibitory concentration of 0.370 ng/mL, an affinity constant of 2.604 × 109 L/mol and no cross-reactivity with other vitamins. Then, a highly sensitive TRFM-ICA was developed, with a visual limit of detection of 10 μg/kg and a cut-off value of 100 μg/kg for qualitative detection and a detection range of 4.125–82.397 μg/kg for quantitative detection. In addition, the test results of real samples were consistent with the results of quantification using microbiological methods, with a coefficient of variation of less than 10%, showing good accuracy and stability, and confirming that the TRFM-ICA is suitable for the analysis of VB12 in real infant formula milk powder samples. In this study, based on the principle of specific recognition of VB12 by monoclonal antibodies (mAbs) against VB12, a time-resolved fluorescence microsphere immunochromatographic assay (TRFM-ICA) was developed to detect the content of VB12 in infant formula by converting biological signals into optical signals. Full article
(This article belongs to the Special Issue Feature Papers of Biosensors)
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11 pages, 1660 KiB  
Article
Enhanced Electrochemiluminescence from Ruthenium-Tagged Immune Complex at Flexible Chains for Sensitive Analysis of Glutamate Decarboxylase Antibody
by Yuyao Zhang, Li Qian, Qian Zhang, Yu Li, Yu Liu and Dechen Jiang
Biosensors 2025, 15(1), 47; https://doi.org/10.3390/bios15010047 - 15 Jan 2025
Viewed by 953
Abstract
Herein, a sensitive electrochemiluminescence (ECL) immunosensor is designed by immobilizing ruthenium-tagged immune complexes at flexible poly-ethylene-glycol (PEG) chains on the electrode surface, which offers more freedom for the collision of the ruthenium complex at the electrode during the initial ECL reaction. The electrochemical [...] Read more.
Herein, a sensitive electrochemiluminescence (ECL) immunosensor is designed by immobilizing ruthenium-tagged immune complexes at flexible poly-ethylene-glycol (PEG) chains on the electrode surface, which offers more freedom for the collision of the ruthenium complex at the electrode during the initial ECL reaction. The electrochemical characterizations confirm the loose structure of the assembled layer with the immune complex, providing an increase in the current and the resultant enhanced ECL emissions. Comparing the sensors with the rigid structure, a 34-fold increase in the maximal ECL emission is recorded when PEG3400 is used as a linker. Using the optimized protocol, the prepared immunosensor exhibits a wide-ranging linear response to the model antibody (glutamate decarboxylase antibody) ranging from 10 pg/mL to 10 ng/mL. The detection limit is almost two orders lower than the value using the classic enzyme-linked immunosorbent assay, which offers a new design to enhance ECL emissions and the resultant analytical performance. Full article
(This article belongs to the Special Issue Feature Papers of Biosensors)
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Review

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22 pages, 3776 KiB  
Review
Challenges in Adapting Fibre Optic Sensors for Biomedical Applications
by Sahar Karimian, Muhammad Mahmood Ali, Marion McAfee, Waqas Saleem, Dineshbabu Duraibabu, Sanober Farheen Memon and Elfed Lewis
Biosensors 2025, 15(5), 312; https://doi.org/10.3390/bios15050312 - 13 May 2025
Viewed by 375
Abstract
Fibre optic sensors (FOSs) have developed as a transformative technology in healthcare, often offering unparalleled accuracy and sensitivity in monitoring various physiological and biochemical parameters. Their applications range from tracking vital signs to guiding minimally invasive surgeries, enabling advancements in medical diagnostics and [...] Read more.
Fibre optic sensors (FOSs) have developed as a transformative technology in healthcare, often offering unparalleled accuracy and sensitivity in monitoring various physiological and biochemical parameters. Their applications range from tracking vital signs to guiding minimally invasive surgeries, enabling advancements in medical diagnostics and treatment. However, the integration of FOSs into biomedical applications faces numerous challenges. This article describes some challenges for adopting FOSs for biomedical purposes, exploring technical and practical obstacles, and examining innovative solutions. Significant challenges include biocompatibility, miniaturization, addressing signal processing complexities, and meeting regulatory standards. By outlining solutions to the stated challenges, it is intended that this article provides a better understanding of FOS technologies in biomedical settings and their implementation. A broader appreciation of the technology, offered in this article, enhances patient care and improved medical outcomes. Full article
(This article belongs to the Special Issue Feature Papers of Biosensors)
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24 pages, 5603 KiB  
Review
Recent Advances in MXene-Based Electrochemical Sensors
by Ziyi Zhao, Jiayi Cao, Boyu Zhu, Xinru Li, Lin Zhou and Bin Su
Biosensors 2025, 15(2), 107; https://doi.org/10.3390/bios15020107 - 13 Feb 2025
Cited by 5 | Viewed by 1531
Abstract
MXene is a new family of two-dimensional nanomaterials with outstanding electrical conductivity, tunable structure, biocompatibility, and a large surface area. Thanks to these unique physicochemical properties, MXene has been used for constructing electrochemical sensors (MECSens) with excellent performance. In particular, the abundant surface [...] Read more.
MXene is a new family of two-dimensional nanomaterials with outstanding electrical conductivity, tunable structure, biocompatibility, and a large surface area. Thanks to these unique physicochemical properties, MXene has been used for constructing electrochemical sensors (MECSens) with excellent performance. In particular, the abundant surface termination of MXene can contribute to greatly enhancing the analytical sensitivity and selectivity of MECSens. Recently, MECSens have been widely applied in many fields including clinical diagnosis, infectious disease surveillance, and food security. However, not all MXene materials are suitable for building electrochemical sensors. In this article, we present an overview of different MECSens that have been developed so far. We begin with a short summary of the preparation and characterization of MECSens. Subsequently, the electrochemical performance, detection strategies, and application scenarios of MECSens are classified and briefly discussed. The article ends with a short conclusion and future perspectives. We hope this article will be helpful for designing and constructing MECSens with outstanding activity for electrochemical analysis. Full article
(This article belongs to the Special Issue Feature Papers of Biosensors)
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21 pages, 3237 KiB  
Review
Electrochemical Technology for the Detection of Tau Proteins as a Biomarker of Alzheimer’s Disease in Blood
by Jianman Wang, Xing Lu and Yao He
Biosensors 2025, 15(2), 85; https://doi.org/10.3390/bios15020085 - 4 Feb 2025
Cited by 1 | Viewed by 1765
Abstract
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder and a significant cause of dementia in elderly individuals, with a growing prevalence in our aging population. Extracellular amyloid-β peptides (Aβ), intracellular tau proteins, and their phosphorylated forms have gained prominence as critical biomarkers for [...] Read more.
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder and a significant cause of dementia in elderly individuals, with a growing prevalence in our aging population. Extracellular amyloid-β peptides (Aβ), intracellular tau proteins, and their phosphorylated forms have gained prominence as critical biomarkers for early and precise diagnosis of AD, correlating with disease progression and response to therapy. The high costs and invasiveness of conventional diagnostic methods, such as positron emission tomography (PET) and magnetic resonance imaging (MRI), limit their suitability for large-scale or routine screening. However, electrochemical (EC) analysis methods have made significant progress in disease detection due to their high sensitivity, excellent specificity, portability, and cost-effectiveness. This article reviews the progress in EC biosensing technologies, focusing on the detection of tau protein biomarkers in the blood (a low-invasive, accessible diagnostic medium). The article then discusses various EC sensing platforms, including their fabrication processes, limit of detection (LOD), sensitivity, and clinical potential to show the role of these sensors as transformers changing the face of AD diagnostics. Full article
(This article belongs to the Special Issue Feature Papers of Biosensors)
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