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Journal of Functional Biomaterials, Volume 16, Issue 5

May 2025 - 42 articles

Cover Story: Unlike adult skin, fetal skin can regenerate without scarring—a phenomenon linked to its extracellular matrix rich in hyaluronan (HA). Inspired by this, we engineered collagen-based dermal templates conjugated with HA to guide skin healing. Primary human macrophages and fibroblasts derived from adult, fetal, and eschar tissues were cultured on these scaffolds. The HA-modified templates promoted a reparative macrophage profile and reduced the expression of fibrosis-associated genes in eschar-derived fibroblasts, supporting the potential of HA-functionalized scaffolds in skin regeneration strategies. View this paper
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Articles (42)

  • Review
  • Open Access
3,586 Views
21 Pages

Biomaterial-Based and Surgical Approaches to Local Hemostasis in Contemporary Oral Surgery: A Narrative Review

  • Atanaska Dinkova,
  • Petko Petrov,
  • Dobromira Shopova,
  • Hristo Daskalov and
  • Stanislava Harizanova

Effective local hemostasis is essential in oral surgery to prevent complications such as delayed healing, infection, and the need for re-intervention. Postoperative bleeding occurs in 4–6% of cases, increasing to 9–12% in patients receivi...

  • Review
  • Open Access
2 Citations
2,157 Views
29 Pages

Research Progress in Medical Biomaterials for Bone Infections

  • Tianxu Lian,
  • Yiwei Wang and
  • Pengfei Zheng

Bone infection is a debilitating condition characterized by inflammation of the bone and its marrow. It poses significant challenges in clinical practice due to its recalcitrant nature and difficulty in eradicating the infecting microorganisms. Recen...

  • Article
  • Open Access
3 Citations
1,333 Views
12 Pages

Conventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic–inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (...

  • Article
  • Open Access
2 Citations
1,604 Views
19 Pages

Stress–Strain State Investigation and Ultimate Load on Femoral Implants Based on S-Type Ti6Al4V Titanium Alloy

  • Ivan Panfilov,
  • Ilya Vilkovyskiy,
  • Evgeniy Sadyrin,
  • Sergei Aizikovich,
  • Alexey N. Beskopylny and
  • Besarion Meskhi

Hip replacement is a widespread surgical procedure that eliminates pain and restores motor functions of the pathologically altered hip joint. The issue lies in the lack of pre-operative strength calculations for implant shapes. So, they tend to break...

  • Article
  • Open Access
2 Citations
981 Views
17 Pages

Metallic biomaterials are prevalent in medical applications. In the treatment of mandibular fractures, the use of metallic biomaterials makes it possible to recover the ability to bite and partially recover speech through preventing ankylosis of the...

  • Review
  • Open Access
1 Citations
2,425 Views
25 Pages

The global spread of infectious diseases has raised public awareness of vaccines, highlighting their essential role in protecting public health. Among the components of modern vaccines, adjuvants have received increasing attention for boosting immune...

  • Review
  • Open Access
1 Citations
5,081 Views
29 Pages

Total Hip Arthroplasty (THA) is a widely used surgical procedure to restore mobility and reduce pain in patients with hip joint disorders. Implant success and longevity are influenced by the selection of appropriate materials. This study presents a c...

  • Article
  • Open Access
2 Citations
1,301 Views
12 Pages

Surface Analysis of Lithium Disilicate Ceramics After Use of Charcoal-Containing Toothpastes

  • Franciele Floriani,
  • Bayaan Jabr,
  • Silvia Rojas-Rueda,
  • Rene Garcia-Contreras,
  • Carlos A. Jurado and
  • Abdulrahman Alshabib

Background: This study evaluated the effect of charcoal-containing toothpaste on the surface roughness of CAD/CAM lithium disilicate ceramic (e.max CAD) after simulated toothbrushing. Methods: Forty-eight e.max CAD ceramic specimens were divided into...

  • Article
  • Open Access
1,270 Views
15 Pages

Versatile Polycaprolactone-Based Drug Delivery System with Enhanced Cytocompatibility and Antibacterial Activity

  • Celine Guder,
  • Anja Hofmann,
  • Therese Schüler,
  • Torsten Sterzenbach,
  • Hans-Peter Wiesmann,
  • Katrin Lorenz,
  • Christian Hannig,
  • Christian Reeps and
  • Benjamin Kruppke

Common antibiotic therapies to treat bacterial infections are associated with systemic side effects and the development of resistance, directly connected to duration and dosage. Local drug delivery systems (DDSs) offer an alternative by localising an...

  • Article
  • Open Access
1,032 Views
13 Pages

In Vivo Cell Migration and Growth Within Electrospun Porous Nanofibrous Scaffolds with Different Pore Sizes in a Mouse Pouch Model

  • David C. Markel,
  • Therese Bou-Akl,
  • Bin Wu,
  • Pawla Pawlitz,
  • Xiaowei Yu,
  • Liang Chen,
  • Tong Shi and
  • Weiping Ren

Cellular infiltration into traditional electrospun nanofibers (NFs) is limited due to their dense structures. We were able to obtain polycaprolactone (PCL) NFs with variable and defined pore sizes and thicknesses by using a customized programmed NF c...

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J. Funct. Biomater. - ISSN 2079-4983Creative Common CC BY license