Antimicrobial Peptides and Their Potential Clinical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Antibacterial Biomaterials".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1198

Special Issue Editors


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Guest Editor
Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland
Interests: antimicrobial peptides; neutrophils; macrophages; biomaterials; regenerative medicine; immunomodulation; veterinary pathology; blood clotting disorders
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Guest Editor
Paediatric Orthopaedic Department, Medical University of Lublin, Gębali 6, 20-093 Lublin, Poland
Interests: tissue regeneration; bone formation; growth modulation; wound healing; biomaterials

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Guest Editor
Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Krakow, Poland
Interests: porous and nonporous materials supported regenerative process: polymer nanocomposites; fibrous materials; polymer membrane; cells–materials interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial peptides (AMPs) are naturally occurring peptides that play a crucial role in the innate immune system, defending against different pathogens and acting as immunomodulators with potential for enhance healing and the treatment of diseases caused by chronic and excessive inflammation.

The Special Issue "Antimicrobial peptides and their potential clinical applications".  explores the structure and properties of natural and synthetic AMPs and their potential clinical applications. This Special Issue is dedicated to understanding biological principles and manufacturing advances, synchronizing the physicochemical properties of biomaterials based on AMPs, and exploring their applications for tissue regeneration, as well as the development of biomaterials for advanced diagnostic technology.

The focus of this issue is on physicochemical characteristics of AMPs and the mechanism of their multiple biological functions, especially the interactions between AMPs, host cells, and tissues; studies on the preparation, performance, and use of AMPs in biomaterials; biomedical devices; the design of new drug carriers; innovative techniques of  pharmaceutical dosage forms; use as components to engineer scaffolds from biomaterials; scaffold-based tissue regeneration and visualization for bone, dental, and muscle tissue engineering; skin regeneration and wound healing; and treatment of infectious diseases.

Research on pre-clinical experiments, clinical studies, and studies on animal models involved in the application of AMPs are warmly welcomed.  

Dr. Joanna Wessely-Szponder
Prof. Dr. Michał Latalski
Dr. Ewa Stodolak-Zych
Guest Editors

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Keywords

  • antimicrobial peptides
  • biomaterials
  • biomedical application
  • tissue regeneration
  • host/biomaterial interactions

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Published Papers (1 paper)

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22 pages, 3744 KiB  
Review
Application of Antimicrobial Peptides (AMPs) in Treatment of Osteomyelitis in Human and Veterinary Orthopedics
by Dominika Nguyen Ngoc, Michał Latalski, Anna Danielewicz, Tomasz Szponder, Joanna Wessely-Szponder and Ewa Mazur
J. Funct. Biomater. 2025, 16(3), 90; https://doi.org/10.3390/jfb16030090 - 5 Mar 2025
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Abstract
Osteomyelitis, a severe bone infection, poses a significant therapeutic challenge in both human and veterinary medicine, especially due to the increasing prevalence of antibiotic-resistant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Conventional treatments, including surgical debridement and systemic antibiotics, often prove inadequate due to [...] Read more.
Osteomyelitis, a severe bone infection, poses a significant therapeutic challenge in both human and veterinary medicine, especially due to the increasing prevalence of antibiotic-resistant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Conventional treatments, including surgical debridement and systemic antibiotics, often prove inadequate due to the ability of bacteria to form biofilms and evade host immune responses. Antimicrobial peptides (AMPs), such as LL-37 and β-defensins, have emerged as a promising alternative therapeutic strategy. AMPs exhibit broad-spectrum antimicrobial activity, including efficacy against resistant strains, and possess immunomodulatory properties that can promote bone regeneration. This article comprehensively reviews AMP applications in treating osteomyelitis across both human and veterinary medicine. We discuss diverse therapeutic approaches, including free AMPs, their conjugation with biomaterials such as collagen and chitosan to enhance delivery and stability, and the development of AMP-based nanoparticles. Furthermore, we analyze preclinical and clinical findings, highlighting the efficacy and safety of AMPs in combating osteomyelitis in both human and animal patients. Finally, we explore future perspectives and challenges, such as optimizing delivery, stability, and efficacy, while minimizing cytotoxicity, and in translating AMP-based therapies into clinical practice to effectively manage this debilitating disease. Full article
(This article belongs to the Special Issue Antimicrobial Peptides and Their Potential Clinical Applications)
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