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Antimicrobial Peptides and Their Potential Clinical Applications
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Antimicrobial Peptides and Their Potential Clinical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Antibacterial Biomaterials".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1769

Special Issue Editors

Dr. Joanna Wessely-Szponder

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Guest Editor
Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland
Interests: antimicrobial peptides; neutrophils; macrophages; biomaterials; regenerative medicine; immunomodulation; veterinary pathology; blood clotting disorders
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Michał Latalski

E-Mail Website
Guest Editor
Paediatric Orthopaedic Department, Medical University of Lublin, Gębali 6, 20-093 Lublin, Poland
Interests: tissue regeneration; bone formation; growth modulation; wound healing; biomaterials
Dr. Ewa Stodolak-Zych

E-Mail Website
Guest Editor
Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, 30-059 Krakow, Poland
Interests: porous and nonporous materials supported regenerative process: polymer nanocomposites; fibrous materials; polymer membrane; cells–materials interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antimicrobial peptides (AMPs) are naturally occurring peptides that play a crucial role in the innate immune system, defending against different pathogens and acting as immunomodulators with potential for enhance healing and the treatment of diseases caused by chronic and excessive inflammation.

The Special Issue "Antimicrobial peptides and their potential clinical applications".  explores the structure and properties of natural and synthetic AMPs and their potential clinical applications. This Special Issue is dedicated to understanding biological principles and manufacturing advances, synchronizing the physicochemical properties of biomaterials based on AMPs, and exploring their applications for tissue regeneration, as well as the development of biomaterials for advanced diagnostic technology.

The focus of this issue is on physicochemical characteristics of AMPs and the mechanism of their multiple biological functions, especially the interactions between AMPs, host cells, and tissues; studies on the preparation, performance, and use of AMPs in biomaterials; biomedical devices; the design of new drug carriers; innovative techniques of  pharmaceutical dosage forms; use as components to engineer scaffolds from biomaterials; scaffold-based tissue regeneration and visualization for bone, dental, and muscle tissue engineering; skin regeneration and wound healing; and treatment of infectious diseases.

Research on pre-clinical experiments, clinical studies, and studies on animal models involved in the application of AMPs are warmly welcomed.  

Dr. Joanna Wessely-Szponder
Prof. Dr. Michał Latalski
Dr. Ewa Stodolak-Zych
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial peptides
  • biomaterials
  • biomedical application
  • tissue regeneration
  • host/biomaterial interactions

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

14 pages, 1812 KiB  
Review
AMP-IBP5: A Multifunctional Antimicrobial Peptide for Advanced Wound Healing and Inflammatory Skin Disorders
by Alafate Abudouwanli, Ge Peng, Mengyao Yang, Wanchen Zhao, Quan Sun, Shan Wang, Yi Tan, Arisa Ikeda, Hideoki Ogawa, Ko Okumura and François Niyonsaba
J. Funct. Biomater. 2025, 16(5), 174; https://doi.org/10.3390/jfb16050174 - 12 May 2025
Viewed by 353
Abstract
Wound healing is a complex, multiphase process crucial for restoring tissue integrity and functionality after injury. Among the emerging therapeutic approaches, antimicrobial peptides (AMPs) have shown substantial promise because of their dual role in microbial defense and cellular modulation. AMP-IBP5, a novel AMP [...] Read more.
Wound healing is a complex, multiphase process crucial for restoring tissue integrity and functionality after injury. Among the emerging therapeutic approaches, antimicrobial peptides (AMPs) have shown substantial promise because of their dual role in microbial defense and cellular modulation. AMP-IBP5, a novel AMP derived from insulin-like growth factor-binding protein 5, exhibits both antimicrobial and wound-healing properties, making it a promising therapeutic candidate. This peptide exhibits robust antimicrobial activity, augments keratinocyte proliferation, increases fibroblast migration, induces angiogenesis, and modulates the immune response. Mechanistically, AMP-IBP5 activates Mas-related G protein-coupled receptors and low-density lipoprotein receptor-related protein 1 (LRP1) in keratinocytes, stimulating IL-8 production and vascular endothelial growth factor expression to accelerate wound healing. This molecule also interacts with LRP1 in fibroblasts to increase cell migration and promote angiogenesis while mitigating inflammatory responses through targeted cytokine modulation. Preclinical studies have demonstrated its remarkable efficacy in promoting tissue repair in diabetic wounds and inflammatory skin conditions, including atopic dermatitis and psoriasis. This review delves into the broad therapeutic potential of AMP-IBP5 across dermatological applications, focusing on its intricate mechanisms of action, comparative advantages, and its path toward clinical and commercial application. Full article
(This article belongs to the Special Issue Antimicrobial Peptides and Their Potential Clinical Applications)
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22 pages, 3744 KiB  
Review
Application of Antimicrobial Peptides (AMPs) in Treatment of Osteomyelitis in Human and Veterinary Orthopedics
by Dominika Nguyen Ngoc, Michał Latalski, Anna Danielewicz, Tomasz Szponder, Joanna Wessely-Szponder and Ewa Mazur
J. Funct. Biomater. 2025, 16(3), 90; https://doi.org/10.3390/jfb16030090 - 5 Mar 2025
Viewed by 1000
Abstract
Osteomyelitis, a severe bone infection, poses a significant therapeutic challenge in both human and veterinary medicine, especially due to the increasing prevalence of antibiotic-resistant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Conventional treatments, including surgical debridement and systemic antibiotics, often prove inadequate due to [...] Read more.
Osteomyelitis, a severe bone infection, poses a significant therapeutic challenge in both human and veterinary medicine, especially due to the increasing prevalence of antibiotic-resistant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Conventional treatments, including surgical debridement and systemic antibiotics, often prove inadequate due to the ability of bacteria to form biofilms and evade host immune responses. Antimicrobial peptides (AMPs), such as LL-37 and β-defensins, have emerged as a promising alternative therapeutic strategy. AMPs exhibit broad-spectrum antimicrobial activity, including efficacy against resistant strains, and possess immunomodulatory properties that can promote bone regeneration. This article comprehensively reviews AMP applications in treating osteomyelitis across both human and veterinary medicine. We discuss diverse therapeutic approaches, including free AMPs, their conjugation with biomaterials such as collagen and chitosan to enhance delivery and stability, and the development of AMP-based nanoparticles. Furthermore, we analyze preclinical and clinical findings, highlighting the efficacy and safety of AMPs in combating osteomyelitis in both human and animal patients. Finally, we explore future perspectives and challenges, such as optimizing delivery, stability, and efficacy, while minimizing cytotoxicity, and in translating AMP-based therapies into clinical practice to effectively manage this debilitating disease. Full article
(This article belongs to the Special Issue Antimicrobial Peptides and Their Potential Clinical Applications)
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