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Journal of Functional Biomaterials, Volume 16, Issue 4

April 2025 - 35 articles

Cover Story: Recent advancements in developing a proper corneal substitute using biofabrication techniques have demonstrated that bioprints simulate both extracellular matrix (ECM)-driven microenvironments and characteristics similar to those of a native cornea. Despite the availability of bioinks embedded with human corneal stromal cells, bioinks that only contain collagen have not yet been optimized to fabricate bioprinted corneas. Our study tackled this by developing customizable 3D bioprints composed of collagen-only bioinks embedded with human corneal stromal cells. These bioprinted structures exhibited promising ECM characteristics, indicating the potential of our approach for engineering artificial corneas. View this paper
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Articles (35)

  • Review
  • Open Access
4 Citations
3,719 Views
43 Pages

Sorafenib—Drug Delivery Strategies in Primary Liver Cancer

  • Piotr Szyk,
  • Beata Czarczynska-Goslinska,
  • Marta Ziegler-Borowska,
  • Igor Larrosa and
  • Tomasz Goslinski

Current primary liver cancer therapies, including sorafenib and transarterial chemoembolization, face significant limitations due to chemoresistance caused by impaired drug uptake, altered metabolism, and other genetic modulations. These challenges c...

  • Article
  • Open Access
1,257 Views
22 Pages

MicroRNA-210 Enhances Cell Survival and Paracrine Potential for Cardiac Cell Therapy While Targeting Mitophagy

  • Rita Alonaizan,
  • Ujang Purnama,
  • Sophia Malandraki-Miller,
  • Mala Gunadasa-Rohling,
  • Andrew Lewis,
  • Nicola Smart and
  • Carolyn Carr

The therapeutic potential of presumed cardiac progenitor cells (CPCs) in heart regeneration has garnered significant interest, yet clinical trials have revealed limited efficacy due to challenges in cell survival, retention, and expansion. Priming CP...

  • Article
  • Open Access
2,092 Views
20 Pages

Bone Regeneration in Defects Created on Rat Calvaria Grafted with Porcine Xenograft and Synthetic Hydroxyapatite Reinforced with Titanium Particles—A Microscopic and Histological Study

  • Antonia Samia Khaddour,
  • Emma Cristina Drăghici,
  • Mihaela Ionescu,
  • Cristina Elena Andrei,
  • Răzvan Eugen Ghiţă,
  • Răzvan Mercuţ,
  • Oana Gîngu,
  • Gabriela Sima,
  • Lavinia Toma Tumbar and
  • Sanda Mihaela Popescu

(1) Background: Alveolar bone regeneration in dentistry has become important with the evolution of implantology. Biomaterials used for bone grafting are increasingly used to provide resistant bone support that is favorable for the insertion of dental...

  • Systematic Review
  • Open Access
4 Citations
4,162 Views
14 Pages

Background: Advanced platelet-rich fibrin + (A-PRF+) represents a third generation of autologous platelet derivatives. Appropriate centrifugation conditions cause the formation of a clot containing platelets, which slowly release growth factors that...

  • Review
  • Open Access
11 Citations
4,140 Views
27 Pages

This review paper provides a comprehensive synthesis of the current advancements in investigations of different titanium-based alloys, including pure titanium, commercially available Ti6Al4V, and modified alloys, such as Ti-Nb-Zr-Fe alloys, for biome...

  • Article
  • Open Access
1 Citations
2,104 Views
17 Pages

Purpose: This paper investigates the biomechanical effect of thermoformed aligners equipped with complementary biomechanical attachments (CBAs) on periodontal ligaments (PDLs) during the expansion process of the maxillary arch. The analysis was condu...

  • Article
  • Open Access
963 Views
14 Pages

Improving surface bioactivity is crucial to acquiring zirconia implants with ideal osteoconductivity. In this work, we enhanced the surface properties of zirconia implants, specifically roughness, hydrophilicity, and osteoconductivity, using a &ldquo...

  • Article
  • Open Access
1,331 Views
16 Pages

Impact of Vitamin D3 Functionalization on the Osteogenic Capacity of Bioinspired 3D Scaffolds Based on Ce-Doped Bioactive Glass and Spongia Agaricina

  • Ana-Maria Seciu-Grama,
  • Sorana Elena Lazăr,
  • Simona Petrescu,
  • Oana Cătălina Mocioiu,
  • Oana Crăciunescu and
  • Irina Atkinson

Reconstruction of extensive bone defects due to age, trauma, or post-illness conditions remains challenging. Biomimetic scaffolds with osteogenic capabilities have been proposed as an alternative to the classical autograft and allograft implants. Thr...

  • Article
  • Open Access
947 Views
12 Pages

Surface Micromorphology of Experimental Composites Doped with Bioactive Glass After Different Storage Times

  • Leonardo Svellenti,
  • Moritz Tanner,
  • Andrea Gubler,
  • Matej Par,
  • Thomas Attin,
  • Phoebe Burrer and
  • Tobias T. Tauböck

Objective: To evaluate the surface micromorphology of bioactive glass-modified resin composite materials after storage in simulated body fluid for different periods of time and ultrasonic cleaning. Materials and methods: A resin composite material (H...

  • Article
  • Open Access
1,275 Views
15 Pages

Evaluation of the Characteristics of Digital Light Processing 3D-Printed Magnesium Calcium Phosphate for Bone Regeneration

  • Peng Zhang,
  • Meiling Zhang,
  • Yoo-Na Jung,
  • Seong-Won Choi,
  • Yong-Seok Lee,
  • Geelsu Hwang and
  • Kwi-Dug Yun

Recent advancements in three-dimensional (3D) printing technology, particularly digital light processing (DLP) 3D printing, have enabled the customization of bone substitutes with specific shapes that match bone defect sizes and geometries. Magnesium...

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J. Funct. Biomater. - ISSN 2079-4983