Journal of Functional Biomaterials, Volume 16, Issue 6

This systematic review aimed to evaluate the potential of combining platelet-rich plasma (PRP) and polybutylene succinate (PBS) for the development of vascular grafts in patients undergoing chemotherapy. Relevant articles published in English or Ital...

This research activity proposes to produce composite hydrogel–bioactive glass. The primary purpose of this research is to develop and optimize 3D-printed scaffolds using doped bioglass, aimed at enhancing bone regeneration in bone defects. The...

Extracorporeal membrane oxygenation (ECMO) is a crucial life support therapy for patients with severe cardiac and respiratory failure. However, the complications associated with venoarterial ECMO (VA-ECMO), including thrombus formation, bleeding, and...

Fiber-reinforced composites (FRCs) are recognized for enhancing the fracture resistance of structurally compromised teeth. However, the optimal orientation and placement of fibers in direct resin composite restorations remain under debate. This study...

Implantoplasty is widely used to treat peri-implantitis by removing biofilms from Ti6Al4V dental implants using rotating drills. This study examined the effects of diamond and tungsten carbide drills, and rotation direction (clockwise/counterclockwis...

Background: This study evaluated and compared the effects of thermal aging on the color stability and mechanical properties of CAD/CAM polymers utilized for provisional restorations. Material and Methods: Three CAD/CAM polymers in this study: CAD-Tem...

To address the dual clinical challenges of poor osseointegration and inadequate analgesia caused by postoperative infections in traditional titanium implants, this study proposes a multifunctional synergistic strategy based on metal—organic fra...

Objective: This study aims to evaluate the stress distribution on endodontically treated anterior teeth restored using different restorative materials and different post lengths versus endocrowns employing finite element analysis (FEA). Methods: An e...

Breast cancer (BC) frequently metastasizes to bone, leading to poor patient prognosis. The infiltration of cancer cells in bone impairs its homeostasis, triggering a pathological interaction between tumors and resident cells. Preclinical models able...

Electrospun collagen-based fibrous mats are of increasing interest for cell culture, regenerative medicine, and tissue engineering. The focus of this investigation is on the assessment of the electrospinning ability of bovine split hide collagen (BSH...

This study evaluated the biological performance in vitro of two 3D-printed hydroxyapatite (HA) and polylactic acid (PLA) composite scaffolds with two different infill densities (50% [HA-PLA50] and 70% [HA-PLA70]). Comparative analysis using MG-63 cel...

The development of osteogenic biomaterials relies on updates in research methodologies. Establishing reasonable modes is the basis for obtaining reliable experimental conclusions. With the advancement in bone immunology, osteoimmunomodulatory propert...

Functional fabrics embedded with active materials that can be released in a controlled manner upon external triggering have been explored for biomedical and cosmetic applications. This study introduces a method for the fabrication of nonwoven fabrics...

Introduction: Although significant advancements have been made in surgical techniques for reconstructing severely resorbed alveolar bone, achieving predictable regeneration remains a considerable challenge. Many conventional ridge augmentation method...

Aim: to evaluate the bone regeneration capacity of two alloplastic biomaterials in a critical-size rat calvarial defect model. Methods: A total of 80 rats were randomized into 8 groups of 10 animals each. An Ø8 mm, critical-size calvarial defe...

Osteosarcoma (OS), a prevalent primary malignant bone tumor in children and adolescents, has maintained consistent treatment protocols since the 1970s combining surgery, chemotherapy, and radiotherapy. While effective for localized tumors, these stra...

Background: In this study, we aimed to investigate the association between a patient’s selection of implant treatment for a missing mandibular second molar and the magnitude of occlusal force, masticatory ability, mandibular morphology, and age...

In the original publication [...]

Objectives: To identify the in vitro techniques used for a microleakage evaluation of restorative materials of coronary structure through a scoping and mapping review. Data: This scoping review aims to answer the following question: “what metho...

Background: The Er:YAG laser has gained attention in dentistry for its potential to enhance microbial disinfection through targeted photothermal and photoacoustic mechanisms. Objective: This systematic review aimed to evaluate the antibacterial and b...

Three-dimensional (3D) cell culture models are widely used to provide a more physiologically relevant microenvironment in which to host and study desired cell types. These models vary in complexity and cost, ranging from simple and inexpensive to hig...

The paper presents the design, manufacturing, and evaluation of a 3D-printed pancreas phantom model used for preoperative surgical planning and surgical training. Several manufacturing and design alternatives have been explored, leading to the final...

In recent years, chemo-photodynamic combinational therapy has become increasingly popular in treating breast cancer. However, the limited accumulation of nanodrugs into tumors (less than 1% of the injected dose) impacts therapeutic efficacy to an ext...

Objective: This in vitro study aimed to evaluate the influence of cervical margin design—tangential versus chamfer—on the fracture resistance of monolithic crowns fabricated from lithium disilicate and zirconia ceramics. Materials and Met...

Background: Orbital floor blowout fractures (OFBF) can have serious consequences for the patient. Selecting the right treatment method and materials is essential. Krenkel’s maxillary sinus implant has been used successfully for more than 40 yea...

Little research has focused on using iron nitride as thermoseed particles in magnetic hyperthermia, although magnetite (Fe₃O₄) is commonly used for this purpose. In the present study, we focus on iron nitride, especially ε-Fe_2–3N. &epsi...

Background: This study evaluates non-surgical therapy combined with injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the levels of matrix metalloproteinase-8 (MMP-8) in the gingival crevicular fluid (GCF) in patients with period...

Apatite pastes derived from eggshell waste (BAp) were implanted onto the calvarial bone of rats, and bone formation was evaluated using X-ray μ-computed tomography (CT) and histological evaluation. BAp was mixed with distilled water to prepare a p...

Critical-size bone defects do not heal spontaneously and require external support, making bone regeneration a central challenge in tissue engineering. Polymeric/ceramic composite scaffolds offer a promising approach to mimic the structural and biolog...

The unique properties of insect silk have attracted attention for years to develop scaffolds for tissue engineering. Combining natural silks with synthetic polymers may benefit biocompatibility, mechanical strength, and elasticity. Silk-modified biom...

Operating under septic conditions poses significant challenges in vascular surgery. Infection is a serious risk when handling synthetic vessel prostheses and is one of the most dreaded complications. In the event of graft infection, an infection-resi...

Novel dentin bonding pretreatment using copper sulfate (CuSO₄) and dipotassium hydrogen phosphate (K₂HPO₄) may create a more hydrophobic environment for dentin bonding. Thus, this study aims to investigate the impact of a CuSO₄ + K₂HPO₄ pretreatment...

Sentinel lymph node (SLN) mapping has been investigated as part of surgical staging in women with early-stage cervical cancer (CC); however, pelvic lymphadenectomy (PLND) remains the standard of care. This study aimed to assess feasibility and safety...

Hydrogel patches have gained significant attention in wound healing applications as they are similar to hydrogel dressings due to their moisture-retentive properties, biocompatibility, and ability to promote tissue regeneration. In this study, gelati...

Biocompatible nanocarriers were formulated by encapsulating medicinal extracts from Bryonia dioica (Red Bryony) and Glaucium leiocarpum (Horned Poppy) using a nanophytosome approach. The nanophytosomes were prepared by employing a thin-film hydration...

The aim of this study was to evaluate the effect of different bleaching protocols, including laser-assisted techniques, on the microhardness, surface roughness, and tribological resistance of selected light-cured composites. Three Estelite Universal...

Background: The socket preservation technique involves filling the bone defect created after tooth extraction with a bone substitute material. This helps to reduce bone resorption of the post-extraction alveolar ridge. Various types of bone substitut...

Innovation in oral implantology is constantly on the move, with a constant search for new biomaterials to overcome many of the limitations of the biomaterials used in current implantable medical devices. This study explores the biocompatibility of an...