Hydroxyapatite Composites for Biomedical Application

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1514

Special Issue Editors


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Guest Editor
Independent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Interests: cell biology; biomaterials; bioceramics; hydroxyapatite; tissue engineering; cell culture models; stem cells

E-Mail Website
Guest Editor
Independent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Interests: biomaterial synthesis; scaffolds; hydroxyapatite ceramic; 3D cell culture; regenerative medicine; tissue regeneration

Special Issue Information

Dear Colleagues,

According to the scientific literature, hydroxyapatite is the predominant type of calcium phosphate (CaP) used in biomedical applications. Its structural similarity to the mineral part of bones’ extracellular matrix explains the preference for its use over other CaPs. Hydroxyapatite is widely used in dental tissue regeneration, maxillofacial surgeries and orthopedic filling bone defects. Its use has been extensively researched; however, in the last few years, an increasing number of studies based on the preparation of modern novel biomaterials for hard tissue regeneration have been observed. The main reason for this observed phenomenon is the emergence of innovative attempts to overcome the limitations of the abovementioned ceramics in terms of their mechanical and microstructural properties, as well as trials aiming to develop innovative modern biomaterials dedicated to specific biomedical applications.

This Special Issue aims to highlight recent advances in the fabrication, characterization and potential usage of novel hydroxyapatite-based biomaterials in biomedical engineering applications. Special emphasis will be placed on comprehensive biological and physico-chemical evaluations and the potential applications of produced composites. Breakthrough scientific research as well as advanced review papers that contribute to the main topic are welcome.

Dr. Vladyslav Vivcharenko
Dr. Paulina Kazimierczak
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydroxyapatite ceramic
  • scaffolds
  • biomaterials
  • biocompatibility
  • physico-chemical properties
  • composites
  • biomedical applications

Published Papers (1 paper)

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Research

20 pages, 6235 KiB  
Article
Generation of Pearl/Calcium Phosphate Composite Particles and Their Integration into Porous Chitosan Scaffolds for Bone Regeneration
by Zhiyi Li, Ihtesham Ur Rehman, Rebecca Shepherd and Timothy E. L. Douglas
J. Funct. Biomater. 2024, 15(3), 55; https://doi.org/10.3390/jfb15030055 - 21 Feb 2024
Viewed by 1296
Abstract
Bone tissue engineering using osteoconductive scaffolds holds promise for regeneration, with pearl powder gaining interest for its bioactive qualities. This study used freeze drying to create chitosan (CS) scaffolds with pearl/calcium phosphate (p/CaP) powders, mimicking bone tissue structurally and compositionally. Characterization included scanning [...] Read more.
Bone tissue engineering using osteoconductive scaffolds holds promise for regeneration, with pearl powder gaining interest for its bioactive qualities. This study used freeze drying to create chitosan (CS) scaffolds with pearl/calcium phosphate (p/CaP) powders, mimicking bone tissue structurally and compositionally. Characterization included scanning electron microscopy (SEM) and mechanical testing. X-ray diffraction (XRD) Fourier-transform infrared–photoacoustic photo-acoustic sampling (FTIR−PAS), and FTIR- attenuated total reflectance (FTIR-ATR) were used to characterize p/CaP. In vitro tests covered degradation, cell activity, and SEM analysis. The scaffolds showed notable compressive strength and modulus enhancements with increasing p/CaP content. Porosity, ranging from 60% to 90%, decreased significantly at higher pearl/CaP ratios. Optimal cell proliferation and differentiation were observed with scaffolds containing up to 30 wt.% p/CaP, with 30 wt.% pearl powder and 30 wt.% p/CaP yielding the best results. In conclusion, pearl/calcium phosphate chitosan (p/CaP_CS) composite scaffolds emerged as promising biomaterials for bone tissue engineering, combining structural mimicry and favourable biological responses. Full article
(This article belongs to the Special Issue Hydroxyapatite Composites for Biomedical Application)
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