The 15th Anniversary of JFB—Innovative Biomaterials for Tissue Engineering: Regeneration of Soft and Hard Tissues

Special Issue Editors


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Guest Editor
1. Dipartimento Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
2. Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
Interests: bone biology; osteogenic mechanisms; bone regenerative strategies; orthopedics; craniofacial surgery
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Special Issue Information

Dear Colleagues,

The year 2025 marks the 15th anniversary of the Journal of Functional Biomaterials, a peer-reviewed, open access journal containing research relevant to the field of materials for biomedical use. So far, JFB has published more than 1700 papers from more than 9000 authors. We appreciate each author, reviewer, and academic editor whose support has brought us to where we are today.

To celebrate this significant milestone, we are publishing a Special Issue entitled “The 15th Anniversary of JFB—Innovative Biomaterials for Tissue Engineering: Regeneration of Soft and Hard Tissues”. The complexity and heterogeneity of human tissues led to the emergence of tissue engineering as an area of biomedical science in the 1980s, and this has since grown exponentially. Tissue engineering aims to regenerate human tissues and organs (e.g., bone, cartilage, skin, and liver) and create a balance between structure and function. Due to its cross-domain nature, tissue engineering (TE) gathers scientists, engineers, and physicians into multidisciplinary teams that employ a variety of methods to construct biological substitutes. Most human native tissues comprise complex three-dimensional (3D) structures, presenting different shapes, architectures, and extracellular matrix compositions. Research groups worldwide have endeavored to develop constructs that can mimic the complexity of native tissues; however, the development of 3D complex organ structures is far from being realized. Furthermore, these tissues, which are not static, have unique functions that are suited to dynamic changes in the conformation of tissues. Therefore, this Special Issue welcomes original articles that present recent advances in biomaterials and TE strategies for the development of biologically functional products with structural organization. In addition, we welcome reviews papers that stimulate creative thinking in this area.

Dr. Pedro Morouço
Dr. Wanda Lattanzi
Guest Editors

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Keywords

  • biomaterials
  • scaffolds
  • bioprinting
  • regenerative medicine
  • cells
  • mesenchymal stromal cells
  • nanotechnologies
  • nanomaterials

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Published Papers (1 paper)

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Review

27 pages, 1365 KiB  
Review
Commercial Biomaterial-Based Products for Tendon Surgical Augmentation: A Scoping Review on Currently Available Medical Devices
by Marta Pluchino, Leonardo Vivarelli, Gianluca Giavaresi, Dante Dallari and Marco Govoni
J. Funct. Biomater. 2025, 16(4), 130; https://doi.org/10.3390/jfb16040130 - 3 Apr 2025
Viewed by 423
Abstract
Tendon defect is one of the common clinical diseases related to the growing population mean age and the number of athletes. Due to an increasing demand for tendon repair surgical interventions, several tendon augmentation products, capable of guaranteeing the necessary biological and visco-elasticity [...] Read more.
Tendon defect is one of the common clinical diseases related to the growing population mean age and the number of athletes. Due to an increasing demand for tendon repair surgical interventions, several tendon augmentation products, capable of guaranteeing the necessary biological and visco-elasticity properties and mechanical support, have been developed. In this regard, commercially available products may be grouped into three main categories: (i) natural, (ii) synthetic, and (iii) hybrid biomaterial-based products. Firstly, to better define the research area of this work, common search engines were employed to acquire information from reports or website portfolios of important competitors in the global tendon repair market. Secondly, public registries and bibliographic databases were also employed to analyse data from registered clinical trials and published clinical studies performed to evaluate the safety and efficacy of each product. Ten new products have been launched on the market in the last fifteen years: advantages, disadvantages, and future perspectives regarding their use for tendon augmentation treatment are discussed. Although hybrid biomaterial-based products may be considered as more oriented to the new frontiers of tendon augmentation technology, future improvements, especially focused on both mechanical properties and biocompatibility, are needed. However, scientific innovations must navigate convoluted clinical regulatory paths, which, due to high costs for investors, long development timelines, and funding shortages, hinder the translation of many scientific discoveries into routine clinical practice. Full article
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