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Journal of Functional Biomaterials, Volume 16, Issue 2

February 2025 - 35 articles

Cover Story: This work presents a novel method for the delivery of anti-fibrotic heparin-binding growth factors via the regenerating agent (RGTA®) OTR4120, which is a glycanase-resistant heparan mimic. This work exploits the ability of OTR4120 (OTR) to capture and present fibroblast growth factor 2 (FGF-2) for full-thickness wound healing applications. Porous type I collagen (COL) scaffolds were chemically functionalized with OTR and loaded with FGF-2. The scaffolds had an even distribution of OTR, gradually released FGF-2 and prevented the expression of pro-fibrotic gene and protein markers by primary human dermal fibroblasts in vitro. Collagen–OTR4120–FGF-2 scaffolds are highly promising materials for combatting fibrosis in full-thickness skin wound healing applications. View this paper
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Articles (35)

  • Article
  • Open Access
2,174 Views
13 Pages

The Relationship Between Peri-Implant Marginal Bone Loss and Resonance Frequency Analysis

  • Esteban Pérez-Pevida,
  • Iván Monteagudo-Villalobos,
  • David Chávarri-Prado,
  • Alejandro Estrada-Martínez,
  • Miguel Beltrán-Guijarro,
  • Markel Diéguez-Pereira and
  • Aritza Brizuela-Velasco

Resonance frequency analysis (RFA) has been used as a diagnostic method to measure implant stability at all stages of healing. In addition to evaluating the status of the peri-implant marginal bone, it can also indicate the most appropriate time to l...

  • Article
  • Open Access
1 Citations
1,711 Views
12 Pages

Preventing Oral Dual Biofilm Development with Innovative Bioactive Varnishes

  • Tainá de Lima Costa,
  • Regina Maria Puppin-Rontani and
  • Aline Rogéria Freire de Castilho

This study introduces innovative varnishes incorporating natural bioactive compounds to inhibit the formation of oral dual biofilms, a critical contributor to dental caries and other oral diseases. The purpose of this study was to evaluate the effect...

  • Article
  • Open Access
2 Citations
2,820 Views
22 Pages

Hydrogel network structures play a crucial role in determining mechanical properties and have broad applications in biomedical and industrial fields. Therefore, their rational design is essential. Herein, we developed a Schiff base-crosslinked hydrog...

  • Article
  • Open Access
1,340 Views
14 Pages

Bisphenol A Release from Fiber-Reinforced vs. Conventional Stainless-Steel Fixed Retainers: An In Vitro Study

  • Efthimia Tsoukala,
  • Niki Maragou,
  • Andriani-Paraskevi Antonelaki,
  • Nikolaos Thomaidis and
  • Iosif Sifakakis

Objectives: The objectives of this study were to investigate in vitro BPA release from two common fiberglass fixed lingual canine-to-canine retainers and to compare these amounts with those released from a conventional multistranded stainless-steel o...

  • Article
  • Open Access
1 Citations
1,077 Views
22 Pages

Effect of Sequential vs. Simultaneous Dual Growth Factor Release from Structured Heparin-Poly-Electrolyte Multilayer Coatings on Peri-Implant Bone Formation and Angiogenesis in Pig Mandibles

  • Philipp Kauffmann,
  • Susanne Wolfer,
  • Christina Behrens,
  • Pauline Schlosser,
  • Christian Dullin,
  • Uwe Schirmer,
  • Klaus Liefeith and
  • Henning Schliephake

The aim of the present study was to test the sequential and simultaneous release of rhBMP2 and rhVEGF165 from poly-l-lysine-heparin (PLL-Hep) poly-electrolyte multilayer (PEM) coating on titanium surfaces for their ability to enhance peri-implant bon...

  • Article
  • Open Access
1 Citations
1,961 Views
19 Pages

In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite

  • Maria Holmström,
  • Sonia Esko,
  • Karin Danielsson and
  • Per Kjellin

Bacterial growth on implant surfaces poses a significant obstacle to the long-term success of dental and orthopedic implants. There is a need for implants that promote osseointegration while at the same time decreasing or preventing bacterial growth....

  • Article
  • Open Access
2 Citations
2,454 Views
13 Pages

The aim of this study was to analyze the marginal bone loss and survival of implants in the augmented sinus area via the lateral window approach. The effect of sinus membrane perforation as well as splinting of the upper structure was analyzed. Two h...

  • Article
  • Open Access
2 Citations
2,034 Views
14 Pages

Customized Titanium Plates for Preventing Mandibular Fractures in Lower Third Molar Extractions

  • Cezara Andreea Onică,
  • Costin Iulian Lupu,
  • Elena-Raluca Baciu,
  • Gabriela Luminița Gelețu,
  • Alice Murariu,
  • Dana Gabriela Budală,
  • Ionuț Luchian and
  • Neculai Onică

The extraction of deeply impacted lower third molars is a common yet challenging surgical procedure associated with complications such as mandibular fractures, pain, and swelling. This study evaluated the effectiveness of customized 3D-printed titani...

  • Article
  • Open Access
3 Citations
1,606 Views
12 Pages

Laser-Induced Photothermal Hydrogels Promote the Proliferation of MC3T3-E1 Preosteoblasts for Enhanced Bone Healing

  • Audrey L. Wu,
  • Abigail F. Wu,
  • Chieh-Ying Chen,
  • Ruaina Lily Hope Moreno,
  • Jia-Lin Wu and
  • Pei-Chun Wong

The nonunion and delayed union of bones are common challenges in orthopedic surgery, even when bone alignment is correct and sufficient mechanical stability is provided. To address this, artificial bone grafts are often applied to fracture gaps or de...

  • Systematic Review
  • Open Access
2 Citations
1,477 Views
21 Pages

Evaluating Bioassays for the Determination of Simvastatin’s Osteogenic Activity: A Systematic Review

  • Lara Steiner Back,
  • Isabella Schönhofen Manso,
  • Mariane Beatriz Sordi,
  • Gabriel Leonardo Magrin,
  • Águedo Aragonês,
  • Ricardo de Souza Magini,
  • Reinhard Gruber and
  • Ariadne Cristiane Cabral Cruz

Objective: Osteogenic differentiation is a complex process, and its analysis requires several biomarkers. Allied with this, there are no standardized bioassays to monitor the activity of simvastatin in osteogenesis in vitro. Therefore, identifying th...

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J. Funct. Biomater. - ISSN 2079-4983