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Journal of Functional Biomaterials, Volume 16, Issue 1

January 2025 - 36 articles

Cover Story:

Bone tissue engineering (BTE) offers an alternative approach to conventional grafts by using biomaterials, progenitor cells and growth factors that aim to improve bone tissue restoration. Various biomaterials have been proposed for BTE, including the polymer poly(3-hexylthiophene) (P3HT), which provides an environment similar to the native extracellular matrix. This study investigated the biological response of osteoprogenitor cells cultured on P3HT thin-polymer film. The findings suggest that P3HT could represent a good coating to induce osteogenic differentiation in vitro, even in absence of specific inductive growth factors, thus representing a promising strategy for bone regenerative medicine. View this paper

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Articles (36)

  • Article
  • Open Access
5 Citations
2,230 Views
15 Pages

Biaxial Flexural Strength and Vickers Hardness of 3D-Printed and Milled 5Y Partially Stabilized Zirconia

  • Sebastian Hetzler,
  • Carina Hinzen,
  • Stefan Rues,
  • Clemens Schmitt,
  • Peter Rammelsberg and
  • Andreas Zenthöfer

This study compares the mechanical properties of 5-mol% yttria partially stabilized zirconia (5Y-PSZ) materials, designed for 3D printing or milling. Three 5Y-PSZ materials were investigated: printed zirconia (PZ) and two milled zirconia materials, V...

  • Article
  • Open Access
2,485 Views
24 Pages

Sacrificing Alginate in Decellularized Extracellular Matrix Scaffolds for Implantable Artificial Livers

  • Chanh-Trung Nguyen,
  • Van Phu Le,
  • Thi Huong Le,
  • Jeong Sook Kim,
  • Sung Hoon Back and
  • Kyo-in Koo

This research introduced a strategy to fabricate sub-millimeter-diameter artificial liver tissue by extruding a combination of a liver decellularized extracellular matrix (dECM), alginate, endothelial cells, and hepatocytes. Vascularization remains a...

  • Article
  • Open Access
1 Citations
2,174 Views
20 Pages

Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist—Synthesis, Characterization, and In Vivo Activity

  • Thomas R. Fuerst,
  • Alexander Marin,
  • Sarah Jeong,
  • Liudmila Kulakova,
  • Raman Hlushko,
  • Katrina Gorga,
  • Eric A. Toth,
  • Nevil J. Singh and
  • Alexander K. Andrianov

Hepatitis C virus (HCV) is a major public health concern, and the development of an effective HCV vaccine plays an important role in the effort to prevent new infections. Supramolecular co-assembly and co-presentation of the HCV envelope E1E2 heterod...

  • Article
  • Open Access
1 Citations
1,669 Views
20 Pages

Effects of Microstructured and Anti-Inflammatory-Coated Cochlear Implant Electrodes on Fibrous Tissue Growth and Neuronal Survival

  • Lennart Fibranz,
  • Wiebke Behrends,
  • Katharina Wulf,
  • Stefan Raggl,
  • Lisa Kötter,
  • Thomas Eickner,
  • Soeren Schilp,
  • Thomas Lenarz and
  • Gerrit Paasche

Cochlear implants are well established devices for treating severe hearing loss. However, due to the trauma caused by the insertion of the electrode and the subsequent formation of connective tissue, their clinical effectiveness varies. The aim of th...

  • Systematic Review
  • Open Access
2 Citations
2,524 Views
23 Pages

The quality of the enamel plays a critical role in the retention and performance of orthodontic brackets. This systematic review and meta-analysis aimed to evaluate the effect of resin infiltration pretreatment on the shear bond strength (SBS) of ort...

  • Article
  • Open Access
3 Citations
1,389 Views
17 Pages

Environmental protection issues have received widespread attention, making material recycling increasingly important. The upcycling of polysulfone (PSF) medical waste, recognized as a high-performance plastic with excellent mechanical properties, des...

  • Article
  • Open Access
2,101 Views
14 Pages

First Clinical Evidence About the Use of a New Silver-Coated Titanium Alloy Instrumentation to Counteract Surgical Site Infection at the Spine Level

  • Lucrezia Leggi,
  • Silvia Terzi,
  • Maria Sartori,
  • Francesca Salamanna,
  • Luca Boriani,
  • Emanuela Asunis,
  • Cristiana Griffoni,
  • Gianluca Giavaresi and
  • Alessandro Gasbarrini

Background: Surgical site infections (SSIs) following spinal instrumentation surgery are among the most concerning complications. This study is aimed at assessing the effectiveness of a new treatment approach for SSIs that includes a single-stage app...

  • Article
  • Open Access
5 Citations
2,067 Views
13 Pages

To overcome limitations of dentin bonding due to collagen degradation at a bonded interface, incorporating bioactive glass (BAG) into dentin adhesives has been proposed to enhance remineralization and improve bonding durability. This study evaluated...

  • Review
  • Open Access
15 Citations
4,766 Views
55 Pages

Three-Dimensional Printing/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances

  • Ana Catarina Sousa,
  • Rui Alvites,
  • Bruna Lopes,
  • Patrícia Sousa,
  • Alícia Moreira,
  • André Coelho,
  • José Domingos Santos,
  • Luís Atayde,
  • Nuno Alves and
  • Ana Colette Maurício

The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field of regenerative medicine. This paper aims to provide a comprehensive overview of 3D...

  • Article
  • Open Access
2,313 Views
24 Pages

Analysis of the Feasibility of the OrthoNail Hybrid Intramedullary Implant in the Human Body with Respect to Material Durability

  • Dominika Grygier,
  • Piotr Kowalewski,
  • Mariusz Opałka,
  • Jakub J. Słowiński,
  • Mateusz Dziubek and
  • Dariusz Pyka

This study focuses on the development and evaluation of the OrthoNail hybrid intramedullary implant for lower limb lengthening in patients requiring significant skeletal reconstruction. The implant addresses the challenges in load-bearing during reha...

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J. Funct. Biomater. - ISSN 2079-4983Creative Common CC BY license