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State of the Art: Biomaterials and Oral Implantology
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State of the Art: Biomaterials and Oral Implantology

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1256

Special Issue Editors

Dr. Markel Dieguez-Pereira

E-Mail Website
Guest Editor
Department of Prosthodontics and Occlusion, School of Dentistry, University of Oviedo, 33006 Oviedo, Spain
Interests: dental implants; oral surgery; guided bone regeneration; prosthodontics; digital dentistry; biomaterials
Prof. Dr. Aritza Brizuela-Velasco

E-Mail Website
Guest Editor
School of Dentistry, Universidad Europea Miguel de Cervantes, C. del Padre Julio Chevalier, 2, 47012 Valladolid, Spain
Interests: dental implants; osseointegration; bone tissues; surfaces; peri-implantitis; prosthodontics; biomechanics; dental implants surgery-guided bone regeneration; dental materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral implantology has undergone a major revolution in the last two decades, especially in the areas of bone regeneration and prosthodontics. Thanks to the development of new techniques and biomaterials, it has become possible to place implants where it was previously impossible and to rehabilitate our patients in a more predictable manner and with better aesthetic results.

However, there are still possible improvements in all these aspects, since nowadays we find certain limitations regarding bone and tissue regeneration techniques and biomaterials, as well as regarding restorative materials.

Therefore, the objective of this Special Issue is to show the state of the art of studies on new techniques in bone regeneration and new biomaterials in oral implantology, as well as new restorative materials and their performance. Both research and review articles are welcome.

Dr. Markel Dieguez-Pereira
Prof. Dr. Aritza Brizuela-Velasco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental biomaterials
  • oral Implantology
  • guided bone regeneration
  • guided tissue regeneration
  • prosthetic materials
  • restorative materials

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Published Papers (2 papers)

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Research

22 pages, 34976 KiB  
Article
Towards Enhanced Osteointegration: A Comparative and In-Depth Study of the Biocompatibility of an Innovative Calcium-Doped Zirconia Coating for Biomedical Implants
by Tchinda Alex, Olivier Joubert, Richard Kouitat-Njiwa and Pierre Bravetti
J. Funct. Biomater. 2025, 16(6), 191; https://doi.org/10.3390/jfb16060191 - 22 May 2025
Viewed by 211
Abstract
Innovation in oral implantology is constantly on the move, with a constant search for new biomaterials to overcome many of the limitations of the biomaterials used in current implantable medical devices. This study explores the biocompatibility of an innovative 5% calcium-to-zirconia (Ca-SZ) coating [...] Read more.
Innovation in oral implantology is constantly on the move, with a constant search for new biomaterials to overcome many of the limitations of the biomaterials used in current implantable medical devices. This study explores the biocompatibility of an innovative 5% calcium-to-zirconia (Ca-SZ) coating deposited by PVD on TA6V substrates for use in oral implantology. In order to determine the contribution of the Ca-SZ coating, an in vitro biocompatibility study was carried out to assess the potential influence of the Ca-SZ coating (1) on the viability and proliferation of saos-2 and HaCaT cells over a short-term exposure period of 96 h, (2) on the synthesis of pro-inflammatory cytokines, and (3) on the synthesis of osteogenic differentiation markers over a long-term exposure period of 21 days, in comparison with reference biomaterials. The sampling consisted of n = 3 biological replicates, and a p-value of <0.05 was used as the threshold for statistical significance. Viability and proliferation kinetics to WST-1 and CyQUANT NF, respectively, showed improved viability/proliferation of Ca-SZ exposed to both cell lines independently. The TNF-alpha and IL-6 assays revealed reduced levels of cytokines compared with the reference biomaterials, including the control groups. In parallel, in Saos-2 cells exposed to Ca-SZ for 21 days under osteogenic conditions increased expression of osteogenic markers, such as the synthesis of soluble collagens, alkaline phosphatase (ALP), osteopontin, and osteocalcin, reflecting dynamic and facilitated osteoblastic differentiation, which was supported by the formation of hydroxyapatite (HA) crystals observed by SEM micrograph and confirmed by EDS mapping. In conclusion, Ca-SZ demonstrates an overall better biocompatibility compared with reference biomaterials, linked to a bioactive interaction of calcium, promoting cell proliferation and differentiation for optimal osteointegration, underlining its potential as a relevant innovation for next-generation implants. Full article
(This article belongs to the Special Issue State of the Art: Biomaterials and Oral Implantology)
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13 pages, 2406 KiB  
Article
The Relationship Between Peri-Implant Marginal Bone Loss and Resonance Frequency Analysis
by Esteban Pérez-Pevida, Iván Monteagudo-Villalobos, David Chávarri-Prado, Alejandro Estrada-Martínez, Miguel Beltrán-Guijarro, Markel Diéguez-Pereira and Aritza Brizuela-Velasco
J. Funct. Biomater. 2025, 16(2), 71; https://doi.org/10.3390/jfb16020071 - 18 Feb 2025
Viewed by 793
Abstract
Resonance frequency analysis (RFA) has been used as a diagnostic method to measure implant stability at all stages of healing. In addition to evaluating the status of the peri-implant marginal bone, it can also indicate the most appropriate time to load the implant. [...] Read more.
Resonance frequency analysis (RFA) has been used as a diagnostic method to measure implant stability at all stages of healing. In addition to evaluating the status of the peri-implant marginal bone, it can also indicate the most appropriate time to load the implant. This in vitro study aimed to evaluate the efficacy of RFA as a diagnostic method for the detection of peri-implant marginal bone loss (MBL). Forty bone-level Klockner Vega implants were placed in a polyurethane block with elastic properties similar to those of the maxillary bone. The insertion torque and primary implant stability at the time of placement were measured using an RFA device. A circumferential peri-implant defect was created by removing the cortical bone portion in each implant using a trephine. The stability values were measured again using RFA. The stability values measured using RFA were lower after the creation of the circumferential peri-implant defect, indicating a statistically significant decrease in implant stability. The results of the study tend to show a relationship between peri-implant marginal bone loss and modifications in implant stability measured by RFA. Full article
(This article belongs to the Special Issue State of the Art: Biomaterials and Oral Implantology)
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