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Functional Biomaterials for Skin Wound Healing
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Functional Biomaterials for Skin Wound Healing

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2930

Special Issue Editor

Dr. Suneel Kumar

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Guest Editor
Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA
Interests: spinal cord injury; wound healing; stem cells; bioengineering; self-assembled nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic wounds are characterized as non-healing wounds due to poor angiogenesis, impaired vascularization, collagen formation, and dysfunctional fibroblasts and keratinocytes in the hypoxic wound environment. These chronic wounds initially result from pathological conditions, such as diabetes, neuronal trauma (CNS injuries), and burn injuries. They are secondarily affected by several bacterial populations. Recently, there has been much debate regarding bio-inspired functional biomaterials and their direct and indirect role in skin wound healing and bacterial disinfection. In this Special Issue, we will focus on the applications of these functional biomaterials in skin wound healing and study their responses under challenging pathological conditions using in vitro, in vivo, and ex vivo systems. Due to the wide scope of these biomaterials, contributions relating to biomaterials, incorporated biomaterials (e.g., skin substitute), CNS injuries, tissue engineering, and biomimetics are also welcome.

Dr. Suneel Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • nanoparticles
  • spinal cord injury
  • traumatic brain injury
  • pressure ulcer
  • wound healing
  • diabetes
  • burn injury

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Published Papers (1 paper)

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Review

18 pages, 1206 KiB  
Review
Recent Advancements in Chitosan-Based Biomaterials for Wound Healing
by Jahnavi Shah, Dhruv Patel, Dnyaneshwari Rananavare, Dev Hudson, Maxwell Tran, Rene Schloss, Noshir Langrana, Francois Berthiaume and Suneel Kumar
J. Funct. Biomater. 2025, 16(2), 45; https://doi.org/10.3390/jfb16020045 - 30 Jan 2025
Cited by 3 | Viewed by 2631
Abstract
Chitosan is a positively charged natural polymer with several properties conducive to wound-healing applications, such as biodegradability, structural integrity, hydrophilicity, adhesiveness to tissue, and bacteriostatic potential. Along with other mechanical properties, some of the properties discussed in this review are antibacterial properties, mucoadhesive [...] Read more.
Chitosan is a positively charged natural polymer with several properties conducive to wound-healing applications, such as biodegradability, structural integrity, hydrophilicity, adhesiveness to tissue, and bacteriostatic potential. Along with other mechanical properties, some of the properties discussed in this review are antibacterial properties, mucoadhesive properties, biocompatibility, high fluid absorption capacity, and anti-inflammatory response. Chitosan forms stable complexes with oppositely charged polymers, arising from electrostatic interactions between (+) amino groups of chitosan and (−) groups of other polymers. These polyelectrolyte complexes (PECs) can be manufactured using various materials and methods, which brings a diversity of formulations and properties that can be optimized for specific wound healing as well as other applications. For example, chitosan-based PEC can be made into dressings/films, hydrogels, and membranes. There are various pros and cons associated with manufacturing the dressings; for instance, a layer-by-layer casting technique can optimize the nanoparticle release and affect the mechanical strength due to the formation of a heterostructure. Furthermore, chitosan’s molecular weight and degree of deacetylation, as well as the nature of the negatively charged biomaterial with which it is cross-linked, are major factors that govern the mechanical properties and biodegradation kinetics of the PEC dressing. The use of chitosan in wound care products is forecasted to drive the growth of the global chitosan market, which is expected to increase by approximately 14.3% within the next decade. This growth is driven by products such as chitoderm-containing ointments, which provide scaffolding for skin cell regeneration. Despite significant advancements, there remains a critical gap in translating chitosan-based biomaterials from research to clinical applications. Full article
(This article belongs to the Special Issue Functional Biomaterials for Skin Wound Healing)
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