J. Clin. Med., Volume 9, Issue 3 (March 2020) – 282 articles
Cover Story (view full-size image): Glucocerebrosidase (GCase) is a retaining β-glucosidase hydrolysing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose. Newly formed GCase is sorted from the ER via the Golgi to lysosomes, where it degrades GlcCer. Impaired lysosomal GlcCer turnover causes Gaucher disease. In keratinocytes, GCase is also transported to lamellar bodies (LBs). Together with its substrate GlcCer, GCase is excreted via LB secretion into the stratum corneum. There, it converts GlcCer to ceramide, a reaction essential for skin barrier function. View this paper
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