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Journal of Clinical Medicine, Volume 9, Issue 3

2020 March - 282 articles

Cover Story: Glucocerebrosidase (GCase) is a retaining β-glucosidase hydrolysing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose. Newly formed GCase is sorted from the ER via the Golgi to lysosomes, where it degrades GlcCer. Impaired lysosomal GlcCer turnover causes Gaucher disease. In keratinocytes, GCase is also transported to lamellar bodies (LBs). Together with its substrate GlcCer, GCase is excreted via LB secretion into the stratum corneum. There, it converts GlcCer to ceramide, a reaction essential for skin barrier function. View this paper
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Articles (282)

  • Article
  • Open Access
22 Citations
5,461 Views
13 Pages

High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1β-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes

  • Shuzo Sakata,
  • Ryo Kunimatsu,
  • Yuji Tsuka,
  • Ayaka Nakatani and ,
  • Tomoka Hiraki,
  • Hidemi Gunji,
  • Naoto Hirose,
  • Makoto Yanoshita,
  • Nurul Aisyah Rizky Putranti and
  • Kotaro Tanimoto
  • + 5 authors+ 0 author

24 March 2020

High-frequency near-infrared diode laser provides a high-peak output, low-heat accumulation, and efficient biostimulation. Although these characteristics are considered suitable for osteoarthritis (OA) treatment, the effect of high-frequency near-inf...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Review
  • Open Access
18 Citations
8,218 Views
21 Pages

24 March 2020

The field of neurocriminology has proposed several treatments (e.g., pharmacological, brain surgery, androgen-deprivation therapy, neurofeedback) to reduce violence proneness, but unfortunately, their effectiveness has been limited due to their side-...

(This article belongs to the Special Issue Clinical and Imaging Assessment of Cognitive Dysfunction in Neurological and Psychiatric Disorders)
  • Article
  • Open Access
38 Citations
3,985 Views
12 Pages

Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age

  • Seung Hun Park,
  • Heeyoon Cho,
  • Sun Jin Hwang,
  • Beomseo Jeon and ,
  • Mincheol Seong,
  • Hosuck Yeom,
  • Min Ho Kang,
  • Han Woong Lim and
  • Yong Un Shin
  • + 4 authors+ 0 author

24 March 2020

In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 yea...

(This article belongs to the Special Issue The Development and Application of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Retinal Diseases)
  • Article
  • Open Access
16 Citations
10,195 Views
11 Pages

Delayed Reconstruction of Palatomaxillary Defect Using Fibula Free Flap

  • Soo-Hwan Byun,
  • Ho-Kyung Lim,
  • Byoung-Eun Yang,
  • Soung-Min Kim and
  • Jong-Ho Lee

24 March 2020

Introduction. The objective of this study was to evaluate a surgical technique and to present the results of delayed reconstruction of palatomaxillary defects using fibula free flap (FFF). Methods. A review was conducted for nine patients who underwe...

(This article belongs to the Special Issue Innovation in Head and Neck Reconstructive Surgery)
  • Article
  • Open Access
3 Citations
3,965 Views
15 Pages

24 March 2020

Background: Population aging poses unprecedented demands on the healthcare system. There is also a scarcity of evidence on self-care intervention to improve objective measures of morbidity and aging-associated functional and physiological measures in...

(This article belongs to the Special Issue Self-Management and Health Promotion in Chronic Disease)
  • Article
  • Open Access
30 Citations
6,099 Views
17 Pages

Novel Biomarkers in Patients with Chronic Kidney Disease: An Analysis of Patients Enrolled in the GCKD-Study

  • Moritz Mirna,
  • Albert Topf,
  • Bernhard Wernly,
  • Richard Rezar and ,
  • Vera Paar,
  • Christian Jung,
  • Hermann Salmhofer,
  • Kristen Kopp,
  • Uta C. Hoppe and
  • Martin Busch
  • + 13 authors+ 8 authors

24 March 2020

Background: Chronic kidney disease (CKD) and cardiovascular diseases (CVD) often occur concomitantly, and CKD is a major risk factor for cardiovascular mortality. Since some of the most commonly used biomarkers in CVD are permanently elevated in pati...

(This article belongs to the Special Issue Novel Biomarkers for Heart Disease)
  • Article
  • Open Access
49 Citations
5,242 Views
12 Pages

Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma

  • Chih-Yung Chiu,
  • Mei-Ling Cheng,
  • Meng-Han Chiang,
  • Chia-Jung Wang and ,
  • Ming-Han Tsai and
  • Gigin Lin
  • + 1 author+ 0 author

24 March 2020

Several metabolomics studies have identified altered metabolic pathways that are related to asthma. However, an integrative analysis of the metabolic responses across blood and urine for a comprehensive framework of asthma in early childhood remains...

(This article belongs to the Section Respiratory Medicine)
  • Communication
  • Open Access
85 Citations
10,500 Views
13 Pages

24 March 2020

Treatment approaches to pediatric obstructive sleep apnea (OSA) have remarkably evolved over the last two decades. From an a priori assumption that surgical removal of enlarged upper airway lymphadenoid tissues (T&A) was curative in the vast majo...

(This article belongs to the Special Issue Treatment of Obstructive Sleep Apnea: State-of-the-Art and Future Directions)
  • Article
  • Open Access
3 Citations
4,637 Views
13 Pages

Tc-99m TRODAT-1 SPECT is a Potential Biomarker for Restless Leg Syndrome in Patients with End-Stage Renal Disease

  • Yi-Chou Hou,
  • Yu-Ming Fan,
  • Ya-Ching Huang,
  • Ruei-Ming Chen and ,
  • Cheng-Hsu Wang,
  • Yi-Te Lin,
  • Tzung-Hai Yen,
  • Kuo-Cheng Lu and
  • Yuh-Feng Lin
  • + 4 authors+ 0 author

24 March 2020

Rationales: Restless leg syndrome (RLS) is a common complication in patients with end-stage renal disease (ESRD). However, there is a lack of biomarkers linking uremic RLS to dopaminergic neurons. Previous studies demonstrated that Tc-99m TRODAT-1 SP...

(This article belongs to the Special Issue Integrated Care and Network Formation for the Treatment of Parkinson’s Disease and Other Movement Disorders)
  • Review
  • Open Access
66 Citations
8,660 Views
10 Pages

24 March 2020

Sarcoidosis is a granulomatous disease of which the etiology remains unknown. The diverse clinical manifestations may challenge clinicians, particularly when conventional markers are inconclusive. From various studies, it has become clear that fluoro...

(This article belongs to the Special Issue Management of Sarcoidosis: Challenges and Solutions)
  • Article
  • Open Access
21 Citations
5,993 Views
15 Pages

Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 1

  • Gaku Tsuji,
  • Akiko Hashimoto-Hachiya,
  • Vu Hai Yen,
  • Sho Miake and ,
  • Masaki Takemura,
  • Yasutaka Mitamura,
  • Takamichi Ito,
  • Maho Murata,
  • Masutaka Furue and
  • Takeshi Nakahara
  • + 5 authors+ 0 author

24 March 2020

Background: IL-33, one of the IL-1 superfamily cytokines, has been shown to be associated with pruritus and inflammation in atopic dermatitis (AD). Furthermore, IL-33 production derived from keratinocytes reportedly has a crucial role in the developm...

(This article belongs to the Section Dermatology)
  • Review
  • Open Access
105 Citations
10,312 Views
26 Pages

Mitophagy in Cardiovascular Diseases

  • Giampaolo Morciano,
  • Simone Patergnani,
  • Massimo Bonora,
  • Gaia Pedriali and ,
  • Anna Tarocco,
  • Esmaa Bouhamida,
  • Saverio Marchi,
  • Gina Ancora,
  • Gabriele Anania and
  • Paolo Pinton
  • + 7 authors+ 2 authors

24 March 2020

Cardiovascular diseases are one of the leading causes of death. Increasing evidence has shown that pharmacological or genetic targeting of mitochondria can ameliorate each stage of these pathologies, which are strongly associated with mitochondrial d...

(This article belongs to the Special Issue The Rise of Mitochondria in Medicine)
  • Article
  • Open Access
20 Citations
5,681 Views
15 Pages

The Wearable Cardioverter-Defibrillator: Experience in 153 Patients and a Long-Term Follow-Up

  • Stephanie L. Rosenkaimer,
  • Ibrahim El-Battrawy,
  • Tobias C. Dreher,
  • Stefan Gerhards and ,
  • Susanne Röger,
  • Jürgen Kuschyk,
  • Martin Borggrefe and
  • Ibrahim Akin
  • + 3 authors+ 0 author

24 March 2020

Background: The wearable cardioverter-defibrillator (WCD) is available for patients at high risk for sudden cardiac death (SCD) when immediate implantable cardioverter-defibrillator (ICD) implantation is not possible or indicated. Patient selection r...

(This article belongs to the Special Issue New Approaches to the Atrial Fibrillation Management)
  • Article
  • Open Access
44 Citations
6,778 Views
27 Pages

Artificial Intelligence-Based Diagnosis of Cardiac and Related Diseases

  • Muhammad Arsalan,
  • Muhammad Owais,
  • Tahir Mahmood,
  • Jiho Choi and
  • Kang Ryoung Park

23 March 2020

Automatic chest anatomy segmentation plays a key role in computer-aided disease diagnosis, such as for cardiomegaly, pleural effusion, emphysema, and pneumothorax. Among these diseases, cardiomegaly is considered a perilous disease, involving a high...

(This article belongs to the Special Issue Emerging Technologies for Medical Imaging - Diagnostics, Monitoring and Therapy of Cancers)
  • Article
  • Open Access
25 Citations
4,220 Views
13 Pages

Early Post-Stroke Infections Are Associated with an Impaired Function of Neutrophil Granulocytes

  • Till van Gemmeren,
  • Ramona Schuppner,
  • Gerrit M. Grosse,
  • Jessica Fering and ,
  • Maria M. Gabriel,
  • René Huber,
  • Hans Worthmann,
  • Ralf Lichtinghagen and
  • Karin Weissenborn
  • + 4 authors+ 0 author

23 March 2020

To investigate whether neutrophil granulocytes’ function relates to post-stroke infections and clinical outcome after stroke, we prospectively recruited 95 patients after ischemic stroke and tested them for their microbiocidal neutrophil functi...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
55 Citations
12,724 Views
21 Pages

Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury

  • Ali Teymoori,
  • Anastasia Gorbunova,
  • Fardzadeh E. Haghish,
  • Ruben Real and ,
  • Marina Zeldovich,
  • Yi-Jhen Wu,
  • Suzanne Polinder,
  • Thomas Asendorf,
  • David Menon and
  • Nicole v. Steinbüchel
  • + 6 authors+ 1 author

23 March 2020

Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine the factorial structur...

(This article belongs to the Section Mental Health)
  • Article
  • Open Access
12 Citations
8,716 Views
10 Pages

Assessment of the Short-Term Effects after High-Inductive Electromagnetic Stimulation of Pelvic Floor Muscles: A Randomized, Sham-Controlled Study

  • Kuba Ptaszkowski,
  • Bartosz Malkiewicz,
  • Romuald Zdrojowy,
  • Lucyna Ptaszkowska and
  • Malgorzata Paprocka-Borowicz

23 March 2020

Background: Physiotherapy should be performed by patients with stress or mixed urinary incontinence (SUI and MUI) to increase the strength and endurance of the pelvic floor muscles (PFMs). A method that can positively affect the pelvic floor is stimu...

(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Urinary and Fecal Incontinence in Women)
  • Article
  • Open Access
24 Citations
4,788 Views
10 Pages

23 March 2020

The quick sepsis-related organ failure assessment (qSOFA) score has been introduced to predict the likelihood of organ dysfunction in patients with suspected infection. We hypothesized that machine-learning models using qSOFA variables for predicting...

(This article belongs to the Section Emergency Medicine)
  • Article
  • Open Access
17 Citations
4,007 Views
13 Pages

Damage-Associated Molecular Patterns and Th-Cell-Related Cytokines Released after Progressive Effort

  • Dorota Kostrzewa-Nowak,
  • Andrzej Ciechanowicz,
  • Jeremy S.C. Clark and
  • Robert Nowak

23 March 2020

Inflammation-induced processes commence with the activation of signalling pathways at the cellular level, which mobilize inflammatory cells and stimulate the secretion of chemokines, cytokines, and damage-associated molecular pattern molecules (DAMPs...

(This article belongs to the Section Immunology & Rheumatology)
  • Article
  • Open Access
4 Citations
3,200 Views
9 Pages

23 March 2020

CTLA-4 and CD28 belong to co-stimulation molecules, the abnormal expression of which can regulate the T cell activation and then affect the degree of immune response. Moreover, blood transfusion reaction (TR) is a kind of immune reaction. Consequentl...

(This article belongs to the Section Hematology)
  • Review
  • Open Access
44 Citations
6,738 Views
13 Pages

Natural History of Arrhythmogenic Cardiomyopathy

  • Giulia Mattesi,
  • Alessandro Zorzi,
  • Domenico Corrado and
  • Alberto Cipriani

23 March 2020

Arrhythmogenic cardiomyopathy (AC) is a heart muscle disease characterized by a scarred ventricular myocardium with a distinctive propensity to ventricular arrhythmias (VAs) and sudden cardiac death, especially in young athletes. Arrhythmogenic right...

(This article belongs to the Special Issue The Metabolic Mechanisms of Cardiomyopathy)
  • Review
  • Open Access
52 Citations
6,834 Views
19 Pages

23 March 2020

The final decision to accept an organ for transplantation remains a subjective one. With “poor organ quality” commonly cited as a major reason for kidney discard, accurate, objective, and reliable quality assessment is essential. In an er...

(This article belongs to the Special Issue Machine Perfusion and Its Effects on Ischemia-Reperfusion Injury in the Era of Organ Shortage in Solid Organ Transplantation)
  • Editorial
  • Open Access
3 Citations
3,588 Views
2 Pages

23 March 2020

According to the current approach [1], bruxism is considered as two different behaviours observed during sleep and wakefulness, respectively, and the single definition for bruxism has been replaced by two separate definitions: Sleep bruxism is a mast...

(This article belongs to the Special Issue Sleep Bruxism—The Controversial Sleep Movement Activity)
  • Article
  • Open Access
9 Citations
4,290 Views
10 Pages

Knowledge of Rare Respiratory Diseases among Paediatricians and Medical School Students

  • María Ángeles Requena-Fernández,
  • Francisco Dasí,
  • Silvia Castillo,
  • Rafael Barajas-Cenobi and ,
  • María Mercedes Navarro-García and
  • Amparo Escribano
  • + 1 author+ 0 author

22 March 2020

Alpha-1-antitrypsin deficiency (AATD) and primary ciliary dyskinesia (PCD) are underdiagnosed rare diseases showing a median diagnostic delay of five to ten years, which has negative effects on patient prognosis. Lack of awareness and education among...

(This article belongs to the Special Issue Rare Respiratory Diseases: A Personal and a Public Health Problem)
  • Article
  • Open Access
18 Citations
7,453 Views
23 Pages

Emergent Properties of the HNF4α-PPARγ Network May Drive Consequent Phenotypic Plasticity in NAFLD

  • Sarthak Sahoo,
  • Divyoj Singh,
  • Priyanka Chakraborty and
  • Mohit Kumar Jolly

22 March 2020

Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in adults and children. It is characterized by excessive accumulation of lipids in the hepatocytes of patients without any excess alcohol intake. With a global...

(This article belongs to the Special Issue Non-Alcoholic Steatohepatitis (NASH))
  • Article
  • Open Access
21 Citations
7,527 Views
16 Pages

Effects of a Multicomponent Exercise Program in Older Adults with Non-Small-Cell Lung Cancer during Adjuvant/Palliative Treatment: An Intervention Study

  • Ilem D. Rosero,
  • Robinson Ramírez-Vélez,
  • Nicolas Martínez-Velilla,
  • Bernardo Abel Cedeño-Veloz and ,
  • Idoia Morilla and
  • Mikel Izquierdo
  • + 1 author+ 0 author

21 March 2020

Clinical intervention studies support the efficacy and safety of exercise programs as a treatment modality for non-small-cell lung cancer (NSCLC) during adjuvant/palliative treatment, but the effectiveness of real-world oncogeriatric services is yet...

(This article belongs to the Special Issue Cancer Rehabilitation and Survivorship)
  • Article
  • Open Access
34 Citations
4,769 Views
16 Pages

Multi-Platform Characterization of Cerebrospinal Fluid and Serum Metabolome of Patients Affected by Relapsing–Remitting and Primary Progressive Multiple Sclerosis

  • Federica Murgia,
  • Lorena Lorefice,
  • Simone Poddighe,
  • Giuseppe Fenu and ,
  • Maria Antonietta Secci,
  • Maria Giovanna Marrosu,
  • Eleonora Cocco and
  • Luigi Atzori
  • + 3 authors+ 0 author

21 March 2020

Background: Multiple sclerosis (MS) is a chronic immunemediated disease of the central nervous system with a highly variable clinical presentation and disease progression. In this study, we investigate the metabolomics profile of patients affected by...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
12 Citations
4,297 Views
11 Pages

Clinical Characteristics and Outcome of Patients with Infective Endocarditis Diagnosed in a Department of Internal Medicine

  • Louis Kreitmann,
  • David Montaigne,
  • David Launay,
  • Sandrine Morell-Dubois and ,
  • Hélène Maillard,
  • Marc Lambert,
  • Eric Hachulla and
  • Vincent Sobanski
  • + 3 authors+ 0 author

21 March 2020

Clinical manifestations of infective endocarditis (IE) can be highly non-specific. Our objective was to describe the clinical characteristics of patients initially referred to a department of internal medicine for a diagnostic work-up, and eventually...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
9 Citations
6,862 Views
35 Pages

21 March 2020

Hematopoietic stem cell transplant recipients are at increased risk of infection and immune dysregulation due to reception of cytotoxic chemotherapy; development of graft versus host disease, which necessitates treatment with immunosuppressive medica...

(This article belongs to the Section Oncology)
  • Review
  • Open Access
22 Citations
4,521 Views
9 Pages

Endoscopic Ultrasound-Guided Treatments for Non-Variceal Upper GI Bleeding: A Review of the Literature

  • Claudio Giovanni De Angelis,
  • Pablo Cortegoso Valdivia,
  • Stefano Rizza,
  • Ludovica Venezia and ,
  • Felice Rizzi,
  • Marcantonio Gesualdo,
  • Giorgio Maria Saracco and
  • Rinaldo Pellicano
  • + 3 authors+ 0 author

21 March 2020

Endoscopic injection of glues, clotting factors, or sclerosing agents is a well-known therapy for the treatment of non-variceal upper gastrointestinal bleeding (NVUGIB), but less is known about endoscopic ultrasound (EUS)-guided treatments. In this s...

(This article belongs to the Special Issue New Trends and Advances in Non-Variceal Gastrointestinal Bleeding)
  • Article
  • Open Access
106 Citations
8,895 Views
17 Pages

Evaluation of Proinflammatory, NF-kappaB Dependent Cytokines: IL-1α, IL-6, IL-8, and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders

  • Karolina Babiuch,
  • Beata Kuśnierz-Cabala,
  • Barbara Kęsek,
  • Krzysztof Okoń and ,
  • Dagmara Darczuk and
  • Maria Chomyszyn-Gajewska
  • + 1 author+ 0 author

21 March 2020

Background: Oral squamous cell carcinoma (OSCC) is a life-threatening disease. It could be preceded by oral potentially malignant disorders (OPMDs). It was confirmed that chronic inflammation can promote carcinogenesis. Cytokines play a crucial role...

(This article belongs to the Special Issue Frontiers in Oral Cancer—Basic and Clinical Sciences)
  • Article
  • Open Access
34 Citations
12,204 Views
8 Pages

21 March 2020

The persistence of neck scarring is a common concern among patients undergoing thyroidectomy. Botulinum toxin A (BTA (Botox)) has been shown to suppress scar enlargement at the incision site. The objective of this study was to evaluate the effect of...

(This article belongs to the Section Endocrinology & Metabolism)
  • Editorial
  • Open Access
402 Citations
61,711 Views
7 Pages

Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)

  • Samuel James Brake,
  • Kathryn Barnsley,
  • Wenying Lu,
  • Kielan Darcy McAlinden and ,
  • Mathew Suji Eapen and
  • Sukhwinder Singh Sohal
  • + 1 author+ 0 author

20 March 2020

The epicenter of the original outbreak in China has high male smoking rates of around 50%, and early reported death rates have an emphasis on older males, therefore the likelihood of smokers being overrepresented in fatalities is high. In Iran, China...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
39 Citations
5,957 Views
11 Pages

20 March 2020

Purpose: Aging lowers brain functionality, and obesity accelerates this process. Resistance exercise can help reverse aging; however, studies examining how it affects brain function and body mass are limited. Thus, this study aimed to investigate the...

(This article belongs to the Special Issue Effects of Lifestyle Factors and Exercise on Brain Plasticity and Underlying Neurobiological Mechanisms)
  • Article
  • Open Access
28 Citations
4,577 Views
20 Pages

Enhanced Antioxidative Defense by Vitamins C and E Consumption Prevents 7-Day High-Salt Diet-Induced Microvascular Endothelial Function Impairment in Young Healthy Individuals

  • Lidija Barić,
  • Ines Drenjančević,
  • Martina Mihalj,
  • Anita Matić and ,
  • Marko Stupin,
  • Luka Kolar,
  • Zrinka Mihaljević,
  • Ines Mrakovčić-Šutić,
  • Vatroslav Šerić and
  • Ana Stupin
  • + 5 authors+ 0 author

20 March 2020

This study aimed to examine whether the oral supplementation of vitamins C and E during a seven-day high salt diet (HS; ~14 g salt/day) prevents microvascular endothelial function impairment and changes oxidative status caused by HS diet in 51 (26 wo...

(This article belongs to the Section Vascular Medicine)
  • Article
  • Open Access
16 Citations
17,335 Views
9 Pages

The Treatment of Ingrown Nail: Chemical Matricectomy With Phenol Versus Aesthetic Reconstruction. A Single Blinded Randomized Clinical Trial

  • Juan Manuel Muriel-Sánchez,
  • Ricardo Becerro-de-Bengoa-Vallejo,
  • Pedro Montaño-Jiménez and
  • Manuel Coheña-Jiménez

20 March 2020

Background: In onychocryptosis surgery, incisional and non-incisional matricectomy is indicated according to the stage. The chemical matricectomy with 88% phenol solution is the gold standard and a wedge resection is indicated for more advanced stage...

(This article belongs to the Section Dermatology)
  • Article
  • Open Access
16 Citations
3,384 Views
16 Pages

20 March 2020

Proteinic arginine dimethylation (PADiMe) is a major post-translational modification. Proteolysis of asymmetric and symmetric PADiMe products releases asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), respectively, two endogen...

(This article belongs to the Special Issue Atherosclerosis: Endothelial Dysfunction and Beyond)
  • Review
  • Open Access
107 Citations
10,309 Views
18 Pages

Ischemia-Reperfusion Injury in Marginal Liver Grafts and the Role of Hypothermic Machine Perfusion: Molecular Mechanisms and Clinical Implications

  • Zoltan Czigany,
  • Isabella Lurje,
  • Moritz Schmelzle,
  • Wenzel Schöning and ,
  • Robert Öllinger,
  • Nathanael Raschzok,
  • Igor M. Sauer,
  • Frank Tacke,
  • Pavel Strnad and
  • Georg Lurje
  • + 11 authors+ 6 authors

20 March 2020

Ischemia-reperfusion injury (IRI) constitutes a significant source of morbidity and mortality after orthotopic liver transplantation (OLT). The allograft is metabolically impaired during warm and cold ischemia and is further damaged by a paradox repe...

(This article belongs to the Special Issue Machine Perfusion and Its Effects on Ischemia-Reperfusion Injury in the Era of Organ Shortage in Solid Organ Transplantation)
  • Article
  • Open Access
1 Citations
2,801 Views
11 Pages

Five Years Outcomes and Predictors of Events in a Single-Center Cohort of Patients Treated with Bioresorbable Coronary Vascular Scaffolds

  • Remzi Anadol,
  • Annika Mühlenhaus,
  • Ann-Kristin Trieb,
  • Alberto Polimeni and ,
  • Thomas Münzel and
  • Tommaso Gori
  • + 1 author+ 0 author

20 March 2020

Introduction: We report outcome data of patients treated with coronary bioresorbable scaffolds up to 5 years and investigate predictors of adverse events. Methods: Consecutive patients treated with at least one coronary bioresorbable scaffold (BRS, A...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
31 Citations
6,131 Views
15 Pages

High Risk of Sustained Ventricular Arrhythmia Recurrence After Acute Myocarditis

  • Laurent Rosier,
  • Amir Zouaghi,
  • Valentin Barré,
  • Raphaël Martins and ,
  • Vincent Probst,
  • Eloi Marijon,
  • Nicolas Sadoul,
  • Samuel Chauveau,
  • Antoine Da Costa and
  • Charles Guenancia
  • + 21 authors+ 16 authors

20 March 2020

Acute myocarditis is associated with cardiac arrhythmia in 25% of cases; a third of these arrhythmias are ventricular tachycardia (VT) or ventricular fibrillation (VF). The implantation of a cardiac defibrillator (ICD) following sustained ventricular...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
19 Citations
4,138 Views
11 Pages

Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine

  • Clara Domínguez-Vivero,
  • Yago Leira,
  • Ana López-Ferreiro,
  • Marta Saavedra and ,
  • Xiana Rodríguez-Osorio,
  • Tomás Sobrino,
  • Francisco Campos,
  • José Castillo and
  • Rogelio Leira
  • + 4 authors+ 0 author

20 March 2020

Even though endothelial dysfunction is known to play a role in migraine pathophysiology, studies regarding levels of endothelial biomarkers in migraine have controversial results. Our aim was to evaluate the role of pentraxin 3 (PTX3) and soluble tum...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
18 Citations
14,797 Views
11 Pages

Cognition in Children with Arachnoid Cysts

  • Ulrika Sandvik,
  • Tomas Adolfsson,
  • Dan N. Jacobson and
  • Kristina Tedroff

20 March 2020

Background: This study aims to evaluate if children with temporal arachnoid cysts (AC) have cognitive symptoms and if neurosurgery improves these. Methods: A prospective case series study including consecutive pediatric patients with temporal AC. The...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
24 Citations
12,613 Views
15 Pages

Increased Amygdala Activations during the Emotional Experience of Death-Related Pictures in Complicated Grief: An fMRI Study

  • Manuel Fernández-Alcántara,
  • Juan Verdejo-Román,
  • Francisco Cruz-Quintana,
  • Miguel Pérez-García and ,
  • Andrés Catena-Martínez,
  • María Inmaculada Fernández-Ávalos and
  • María Nieves Pérez-Marfil
  • + 2 authors+ 0 author

20 March 2020

Complicated grief (CG) is associated with alterations in various components of emotional processing. The main aim of this study was to identify brain activations in individuals diagnosed with CG while they were observing positive, negative, and death...

(This article belongs to the Special Issue Clinical and Imaging Assessment of Cognitive Dysfunction in Neurological and Psychiatric Disorders)
  • Article
  • Open Access
18 Citations
4,911 Views
13 Pages

A Novel Predictive Model for In-Hospital Mortality Based on a Combination of Multiple Blood Variables in Patients with ST-Segment-Elevation Myocardial Infarction

  • Yuhei Goriki,
  • Atsushi Tanaka,
  • Kensaku Nishihira,
  • Atsushi Kawaguchi and ,
  • Masahiro Natsuaki,
  • Nozomi Watanabe,
  • Keiichi Ashikaga,
  • Nehiro Kuriyama,
  • Yoshisato Shibata and
  • Koichi Node
  • + 5 authors+ 0 author

20 March 2020

In emergency clinical settings, it may be beneficial to use rapidly measured objective variables for the risk assessment for patient outcome. This study sought to develop an easy-to-measure and objective risk-score prediction model for in-hospital mo...

(This article belongs to the Special Issue Therapies for Myocardial Injury and Infarction)
  • Article
  • Open Access
24 Citations
3,712 Views
17 Pages

Biphasic Temporal Relationship between Cancers and Systemic Sclerosis: A Clinical Series from Montpellier University Hospital and Review of the Literature

  • Léo Partouche,
  • Radjiv Goulabchand,
  • Alexandre Thibault Jacques Maria,
  • Sophie Rivière and ,
  • Christian Jorgensen,
  • Valérie Rigau,
  • Céline Bourgier,
  • Didier Bessis,
  • Alain Le Quellec and
  • Philippe Guilpain
  • + 7 authors+ 2 authors

20 March 2020

Cancer among patients with systemic sclerosis (SSc) would appear to be more prevalent than in the general population. Pathophysiological hypotheses are multiple, involving intertwined factors such as immune system antitumoral response, oxygen species...

(This article belongs to the Section Immunology & Rheumatology)
  • Article
  • Open Access
24 Citations
4,220 Views
12 Pages

Effects of Contemporary Irrigant Activation Schemes and Subsequent Placement of an Interim Dressing on Bacterial Presence and Activity in Root Canals Associated with Asymptomatic Apical Periodontitis

  • Alexandre P. L. Carvalho,
  • Laura C. L. Nardello,
  • Fernanda S. Fernandes,
  • Fernanda P. Bruno and ,
  • Luiza R. Paz,
  • Elaine F. Iglecias,
  • Heitor M. Honório,
  • Márcia P. A. Mayer,
  • Giulio Gavini and
  • Ericka T. Pinheiro
  • + 5 authors+ 0 author

20 March 2020

New tools for activating endodontic irrigants have evolved, yet their impact on root canal disinfection, in comparison to the passive placing of an inter-visit medication, have not yet been fully elucidated. The use of DNA- and rRNA-based methods may...

(This article belongs to the Special Issue New Ways to Disinfect and Fill Dental Hard Tissues)
  • Article
  • Open Access
29 Citations
4,442 Views
11 Pages

Multifunctional Properties of Quercitrin-Coated Porous Ti-6Al-4V Implants for Orthopaedic Applications Assessed In Vitro

  • Maria Antonia Llopis-Grimalt,
  • Aina Arbós,
  • Maria Gil-Mir,
  • Aleksandra Mosur and ,
  • Prathamesh Kulkarni,
  • Armando Salito,
  • Joana M. Ramis and
  • Marta Monjo
  • + 3 authors+ 0 author

20 March 2020

(1) One strategy to improve the outcome of orthopedic implants is to use porous implants with the addition of a coating with an antibacterial biomolecule. In this study, we aimed to produce and test the biocompatibility, the osteopromotive (both unde...

(This article belongs to the Special Issue Latest Clinical And Basic Science Advances In Bone Regeneration)
  • Review
  • Open Access
87 Citations
12,118 Views
14 Pages

The Role of Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles (MSC-EVs) in Normal and Abnormal Hematopoiesis and Their Therapeutic Potential

  • Aristea K. Batsali,
  • Anthie Georgopoulou,
  • Irene Mavroudi,
  • Angelos Matheakakis and ,
  • Charalampos G. Pontikoglou and
  • Helen A. Papadaki
  • + 1 author+ 0 author

20 March 2020

Mesenchymal stem cells (MSCs) represent a heterogeneous cellular population responsible for the support, maintenance, and regulation of normal hematopoietic stem cells (HSCs). In many hematological malignancies, however, MSCs are deregulated and may...

(This article belongs to the Special Issue Mesenchymal Stem/Stromal Cells in Immunity and Disease)
  • Review
  • Open Access
16 Citations
5,718 Views
11 Pages

Body Mass Index and Calprotectin Blood Level Correlation in Healthy Children: An Individual Patient Data Meta-Analysis

  • Anais Grand,
  • Emmanuelle Rochette,
  • Frederic Dutheil,
  • David Gozal and ,
  • Valeria Calcaterra,
  • Roberto Berni Canani,
  • Nazan Cobanoglu,
  • Joep P. M. Derikx,
  • Gianluca Terrin and
  • Etienne Merlin
  • + 6 authors+ 1 author

20 March 2020

Background: Calprotectin (CP) is a protein complex involved in many inflammatory diseases. Obesity is characterized by low-grade inflammation and elevated circulating levels of calprotectin. However, associations between body mass index (BMI) and cal...

(This article belongs to the Section Endocrinology & Metabolism)
  • Article
  • Open Access
28 Citations
8,490 Views
9 Pages

Analysis of Predisposing Factors for Rapid Dental Calculus Formation

  • Carla Fons-Badal,
  • Antonio Fons-Font,
  • Carlos Labaig-Rueda,
  • M. Fernanda Solá-Ruiz and ,
  • Eduardo Selva-Otaolaurruchi and
  • Rubén Agustín-Panadero
  • + 1 author+ 0 author

20 March 2020

Background: Calculus accumulation varies widely between individuals. Dental calculus has been associated with the principal periodontal diseases. The aim of this study was to analyze individual characteristics, and salivary and microbiological parame...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

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J. Clin. Med. - ISSN 2077-0383