J. Clin. Med., Volume 9, Issue 4 (April 2020) – 350 articles
Cover Story (view full-size image): Natural killer (NK) cells are vital innate immune defenders against hepatitis C (HCV) infection. NK cells promote HCV clearance in acute HCV infection, however, in the context of chronic HCV infection NK cells display deficient interferon gamma (IFN-γ) production, promoting viral persistence. In contrast, cytotoxicity remains throughout: While cytotoxicity contributes to acute viral clearance, excessive degranulation in chronic HCV infection results in tissue damage. Increased expression of inhibitory receptors on NK cells such as NKG2A, and decreased expression of natural cytotoxicity receptors (NCRs) such as NKp30 and NKp46 further contribute to viral persistence chronic HCV. View this paper.
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