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Journal of Clinical Medicine, Volume 9, Issue 4

April 2020 - 350 articles

Cover Story: Natural killer (NK) cells are vital innate immune defenders against hepatitis C (HCV) infection. NK cells promote HCV clearance in acute HCV infection, however, in the context of chronic HCV infection NK cells display deficient interferon gamma (IFN-γ) production, promoting viral persistence. In contrast, cytotoxicity remains throughout: While cytotoxicity contributes to acute viral clearance, excessive degranulation in chronic HCV infection results in tissue damage. Increased expression of inhibitory receptors on NK cells such as NKG2A, and decreased expression of natural cytotoxicity receptors (NCRs) such as NKp30 and NKp46 further contribute to viral persistence chronic HCV. View this paper.
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Articles (350)

  • Article
  • Open Access
18 Citations
4,791 Views
16 Pages

Safety Profile of Biologics Used in Rheumatology: An Italian Prospective Pharmacovigilance Study

  • Maria Antonietta Barbieri,
  • Giuseppe Cicala,
  • Paola Maria Cutroneo,
  • Elisabetta Gerratana,
  • Caterina Palleria,
  • Caterina De Sarro,
  • Ada Vero,
  • Luigi Iannone,
  • Antonia Manti and
  • Emilio Russo
  • + 3 authors

24 April 2020

Post-marketing surveillance activities are essential to detect the risk/benefit profile of biologic disease-modifying antirheumatic drugs (bDMARDs) in inflammatory arthritis. The aim of this study was to evaluate adverse events (AEs) in patients trea...

  • Article
  • Open Access
18 Citations
4,462 Views
14 Pages

Influence of Anesthesia and Clinical Variables on the Firing Rate, Coefficient of Variation and Multi-Unit Activity of the Subthalamic Nucleus in Patients with Parkinson’s Disease

  • Michael J. Bos,
  • Ana Maria Alzate Sanchez,
  • Raffaella Bancone,
  • Yasin Temel,
  • Bianca T.A. de Greef,
  • Anthony R. Absalom,
  • Erik D. Gommer,
  • Vivianne H.J.M. van Kranen-Mastenbroek,
  • Wolfgang F. Buhre and
  • Mark J. Roberts
  • + 1 author

24 April 2020

Background: Microelectrode recordings (MER) are used to optimize lead placement during subthalamic nucleus deep brain stimulation (STN-DBS). To obtain reliable MER, surgery is usually performed while patients are awake. Procedural sedation and analge...

  • Article
  • Open Access
19 Citations
3,699 Views
15 Pages

Post-Traumatic Sepsis Is Associated with Increased C5a and Decreased TAFI Levels

  • Jan Tilmann Vollrath,
  • Ingo Marzi,
  • Anna Herminghaus,
  • Thomas Lustenberger and
  • Borna Relja

24 April 2020

Background: Sepsis frequently occurs after major trauma and is closely associated with dysregulations in the inflammatory/complement and coagulation system. Thrombin-activatable fibrinolysis inhibitor (TAFI) plays a dual role as an anti-fibrinolytic...

  • Article
  • Open Access
33 Citations
3,613 Views
11 Pages

Incident Comorbidities, Aging and the Risk of Stroke in 608,108 Patients with Atrial Fibrillation: A Nationwide Analysis

  • Laurent Fauchier,
  • Alexandre Bodin,
  • Arnaud Bisson,
  • Julien Herbert,
  • Pascal Spiesser,
  • Nicolas Clementy,
  • Dominique Babuty,
  • Tze-Fan Chao and
  • Gregory Y. H. Lip

24 April 2020

Background: We hypothesized that the change in stroke risk profile between baseline and follow-up may be a better predictor of ischemic stroke than the baseline stroke risk determination using the CHA2DS2-VASc score ((congestive heart failure, hypert...

  • Article
  • Open Access
13 Citations
4,713 Views
10 Pages

24 April 2020

The aim of this study is to evaluate the effects on survival outcomes of the disease burden before interval debulking surgery (IDS), surgical complexity, and residual disease after IDS in advanced-stage ovarian cancer treated with neoadjuvant chemoth...

  • Review
  • Open Access
503 Citations
54,798 Views
29 Pages

The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control

  • Yosra A. Helmy,
  • Mohamed Fawzy,
  • Ahmed Elaswad,
  • Ahmed Sobieh,
  • Scott P. Kenney and
  • Awad A. Shehata

24 April 2020

A pneumonia outbreak with unknown etiology was reported in Wuhan, Hubei province, China, in December 2019, associated with the Huanan Seafood Wholesale Market. The causative agent of the outbreak was identified by the WHO as the severe acute respirat...

  • Article
  • Open Access
10 Citations
4,029 Views
9 Pages

24 April 2020

This study proposes a method for measuring the volumetric change of alveolar bone after dental implant surgery using computed tomography (CT). A total of 40 implants in 20 patients (15 males and 5 females) were selected. The types of implants used we...

  • Review
  • Open Access
47 Citations
14,587 Views
25 Pages

Detection of Platelet-Activating Antibodies Associated with Heparin-Induced Thrombocytopenia

  • Brigitte Tardy,
  • Thomas Lecompte,
  • François Mullier,
  • Caroline Vayne and
  • Claire Pouplard

24 April 2020

Heparin-induced thrombocytopenia (HIT) is a prothrombotic immune drug reaction caused by platelet-activating antibodies that in most instances recognize platelet factor 4 (PF4)/polyanion complexes. Platelet activation assays (i.e., functional assays)...

  • Review
  • Open Access
24 Citations
7,246 Views
14 Pages

Therapeutic Physical Exercise Post-Treatment in Breast Cancer: A Systematic Review of Clinical Practice Guidelines

  • Alicia del-Rosal-Jurado,
  • Rita Romero-Galisteo,
  • Manuel Trinidad-Fernández,
  • Manuel González-Sánchez,
  • Antonio Cuesta-Vargas and
  • Maria Ruiz-Muñoz

24 April 2020

Advances achieved in diagnosis and improvements in treatment for breast cancer have resulted in a favourable survival rate. Therapeutic physical exercise (TPE) is presented as an intervention strategy that seeks to improve the functional capabilities...

  • Article
  • Open Access
4 Citations
3,104 Views
8 Pages

24 April 2020

Sugammadex reverses the rocuronium-induced neuromuscular block by trapping the cyclopentanoperhydrophenanthrene ring of rocuronium. Dexamethasone shares the same steroidal structure with rocuronium. The purpose of this study was to evaluate the influ...

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J. Clin. Med. - ISSN 2077-0383