Table of Contents
J. Clin. Med., Volume 7, Issue 9 (September 2018)
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Cover Story (view full-size image) Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal lining of the upper [...] Read more. Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal lining of the upper aerodigestive tract. Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. HPV-related HNSCCs and HPV-unrelated HNSCCs differ with respect to the molecular mechanisms underlying their oncogenic processes. To diagnose the HPV-related HNSCCs, various methods including P16 immunohistochemistry, FISH, and genetic analyses of the HPV gene from histopathological and liquid biopsy specimens have been employed. The cover image represents Mechanism of carcinogenesis by HPV. View this paper