Special Issue "Potential Pathogenic Mechanisms of Multiple Sclerosis"
Deadline for manuscript submissions: closed (30 September 2018)
Assoc. Prof. Judith Greer
Knowledge of the mechanisms that underlie the development of multiple sclerosis (MS) is important for appropriate therapeutic interventions. However, the initiating events that lead to MS are still unknown, and the relative merits of “outside-in” (i.e., autoimmune) vs. “inside-out” (i.e., primary central nervous system damage) models for development of MS have been debated. Genetics undoubtedly play an important role in susceptibility to MS, but the relative contribution of individual genes remains to be determined, and little is yet known of genes that affect the course of disease. Female gender is one of the major risk factors for MS, but, conversely, some uniquely female events such as pregnancy are protective in MS. Environmental factors (diet, gut flora, stress, exposure to chemicals, toxins or UVB) are also likely to influence the pathogenesis of MS. Even cell types once thought to be of little interest in MS (e.g., neutrophils, platelets) are now being proposed as important players in development of disease. The present Special Issue aims to explore these potential pathogenic mechanisms in more detail.
Assoc. Prof. Judith Greer
Prof. Pamela McCombe
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Multiple sclerosis
- primary CNS damage
- genetics of MS
- environmental factors
- gender and MS
- innate immune cells in MS