Next Article in Journal
Application and Validation of Activity Monitors’ Epoch Lengths and Placement Sites for Physical Activity Assessment in Exergaming
Next Article in Special Issue
The Effect of Statin Added to Systemic Anticancer Therapy: A Meta-Analysis of Randomized, Controlled Trials
Previous Article in Journal
Translational Medicine in Pulmonary-Renal Crosstalk: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS and Chemoattractants in Dyspneic Patients with Uremic Lung Injury
Previous Article in Special Issue
Clinical Outcome and Management for Geriatric Traumatic Injury: Analysis of 2688 Cases in the Emergency Department of a Teaching Hospital in Taiwan
Open AccessArticle

Fibrosis Staging Using Direct Serum Biomarkers is Influenced by Hepatitis Activity Grading in Hepatitis C Virus Infection

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Miki 761-0701, Japan
Department of Clinical Laboratory, Kagawa University Hospital, Miki 761-0701, Japan
Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu 761-0123, Japan
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(9), 267;
Received: 15 August 2018 / Revised: 7 September 2018 / Accepted: 9 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Advanced Analytical Methods in Clinical Diagnosis and Therapy)
Background: Chronic liver diseases (CLDs) generally progress from inflammation to fibrosis and finally to carcinogenesis. Staging of liver fibrosis progression is inevitable for the management of CLD patients. The purpose of this study was to compare the diagnostic abilities of Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA-M2BP), Enhanced liver fibrosis (ELF) score, Fibrosis-4 index, and AST to platelet ratio index (APRI) based on histopathological analysis of liver biopsy samples, from patients with positive Hepatitis C Virus (HCV) infection. Methods: Japanese patients with HCV infection who underwent liver biopsy examinations were enrolled in this study. WFA-M2BP levels and ELF scores were calculated using preserved serum samples. The fibrosis staging and activity grading were assessed using a modified METAVIR score. Results: A total of 122 patients were enrolled; the cohort included 27 patients with stage 1, 66 with stage 2, 20 with stage 3, and nine with stage 4 fibrosis. All four biomarkers distinguished stage 3 and stage 2 fibrosis. ROC curves revealed that all four fibrosis biomarkers presented AUC values greater than 0.8. Each of the four biomarkers in stage 2 was significantly different between the activity grade 1 and 2 groups. Conclusion: Fib-4 index and APRI were comparable with WFA-M2BP and ELF score in the diagnosis of advanced liver fibrosis in Japanese patients with HCV infection. All four biomarkers of liver fibrosis were influenced by histopathological activity grading, which implies that liver biopsy should be the gold standard to evaluate liver fibrosis staging even though several noninvasive biomarkers have been investigated well. View Full-Text
Keywords: liver cirrhosis; biomarkers; hepatitis C; chronic; biopsy; needle; interferons liver cirrhosis; biomarkers; hepatitis C; chronic; biopsy; needle; interferons
Show Figures

Figure 1

MDPI and ACS Style

Fujita, K.; Kuroda, N.; Morishita, A.; Oura, K.; Tadokoro, T.; Nomura, T.; Yoneyama, H.; Arai, T.; Himoto, T.; Watanabe, S.; Masaki, T. Fibrosis Staging Using Direct Serum Biomarkers is Influenced by Hepatitis Activity Grading in Hepatitis C Virus Infection. J. Clin. Med. 2018, 7, 267.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop