Association of Pre-Eclampsia with Carotid Artery Intima–Media Thickness and Non-Alcoholic Fatty Liver Disease
Abstract
1. Introduction
2. Experimental Section
2.1. Ethics Approval
2.2. Study Population
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Variable | Mean ± SD (n = 42) |
---|---|
Mother’s age (years) | 31.43 ± 5.58 |
Gestational age (week) | 33.67 ± 2.88 |
BMI, kg/m3 | 31.47 ± 3.63 |
Systolic blood pressure (mmHg) | 114.28 ± 16.03 |
Diastolic blood pressure (mmHg) | 74.28 ± 14.51 |
Hb, g/dL | 12.3 ± 1.7 |
PLT × 103/mL | 192.5 ± 54.4 |
TG, mg/dL | 319.8 ± 108.6 |
CHOL, mg/dL | 217.5 ± 58.5 |
LDL, mg/dL | 127.8 ± 37.9 |
HDL, mg/dL | 54.1 ± 6.5 |
AST, U/L | 26.2 ± 12.6 |
ALT, U/L | 24.4 ± 21.5 |
LDH, mg/dL | 383.6 ± 146.3 |
24-h urine creatinine, g/mmol | 917.2 ± 238.3 |
24-h urine protein, g/mmol | 723.8 ± 356.5 |
24-h urine volume, g/mmol | 1745.8 ± 501.9 |
Intima–media thickness of the right carotid artery, mm | 0.55 ± 0.09 |
Intima–media thickness of the left carotid artery, mm | 0.54 ± 0.10 |
Variable | Status | Frequency (%) |
---|---|---|
Gravid | One | 11 (26.2) |
Two | 13 (31) | |
Three | 10 (23.8) | |
Four | 5 (11.9) | |
Five | 3 (7.1) | |
Parity | Zero | 15 (35.7) |
One | 12 (28.6) | |
Two | 13 (31) | |
Three | 2 (4.8) | |
History of hypertension | Yes | 4 (9.5) |
No | 38 (90.5) | |
History of pre-eclampsia | Yes | 7 (16.7) |
No | 35 (83.3) | |
Non-alcoholic fatty liver | Yes | 19 (45.2) |
No | 23 (54.8) |
Variable | Mean ± SD | Significance Level | |
---|---|---|---|
Healthy Pregnant Women | Pregnant Women with Pre-Eclampsia | ||
Mother’s age (years) | 30.00 ± 5.92 | 32.86 ± 4.95 | 0.098 |
Gestational age (weeks) | 33.57 ± 3.22 | 33.76 ± 2.57 | 0.833 |
BMI (kilograms per square meter) | 30.65 ± 3.41 | 32.30 ± 3.75 | 0.144 |
Systolic blood pressure (mmHg) | 102.86 ± 8.30 | 125.71 ± 13.53 | >0.001 |
Diastolic blood pressure (mmHg) | 64.76 ± 7.50 | 83.81±13.59 | >0.001 |
Hb | 12.53 ± 1.14 | 12.33 ± 1.14 | 0.624 |
PLT | 18,361.05 ± 4187.80 | 202,142.8 ± 665,051.74 | 0.279 |
TG | 322.14 ± 91.15 | 316.62 ± 125.49 | 0.871 |
CHOL | 191.24 ± 36.69 | 243.67 ± 64.91 | 0.003 |
LDL | 121.24 ± 21.72 | 134.33 ± 48.6 | 0.267 |
HDL | 54.38 ± 7.83 | 54.24 ± 5.90 | 0.947 |
AST | 20.76 ± 5.00 | 31.48 ± 15.60 | 0.005 |
ALT | 13.90 ± 7.08 | 29.19 ± 32.59 | 0.042 |
LDH | 370.49 ± 158.92 | 397.42 ± 136.00 | 0.558 |
24-h urine protein | 85.59 ± 113.19 | 599.90 ± 972.2 | 0.027 |
24-h urine creatinine | 908.86 ± 175.50 | 925.38 ± 292.73 | 0.826 |
24-h urine volume | 1942.65 ± 396.99 | 1548.90 ± 526.88 | 0.009 |
Intima–media thickness of the right carotid artery | 0.51 ± 0.08 | 0.60 ± 0.07 | 0.001 |
Intima–media thickness of the left carotid artery | 0.10 ± 0.50 | 0.59 ± 0.09 | 0.003 |
Variable | Frequency (%) | Significance Level | ||
---|---|---|---|---|
Status | Healthy Pregnant Women | Pregnant Women with Pre-eclampsia | ||
Gravid | One | 5 (23.8) | 28.6 (6) | 0.859 |
Two | 8 (38.1) | 23.8 (5) | ||
Three | 5 (23.8) | 23.8 (5) | ||
Four | 2 (9.5) | 14.3 (3) | ||
Five | 1 (4.8) | 9.5 (2) | ||
Parity | Zero | 8 (38.1) | 33.3 (7) | 0.479 |
One | 7 (33.3) | 23.8 (5) | ||
Two | 6 (28.6) | 33.3 (7) | ||
Three | 0.0 (0) | 9.5 (2) | ||
History of hypertension | Yes | 0.0 (0) | 19.0 (4) | 0.053 |
No | 100 (21) | 81.0 (17) | ||
History of pre-eclampsia | Yes | 0.0 (0) | 33.3 (7) | 0.004 |
No | 100 (21) | 66.7 (14) | ||
Non-alcoholic fatty liver | Yes | 23.8 (5) | 66.7 (14) | 0.006 |
Variable | Beta Coefficient | Student’s t | Significance Level |
---|---|---|---|
Mother’s age (years) | 0.146 | 0.922 | 0.328 |
BMI (kilograms per square meter) | 0.023 | 0.171 | 0.865 |
CHOL | 0.172 | 0.978 | 0.335 |
AST | −0.383 | −1.240 | 0.223 |
ALT | 0.340 | 1.113 | 0.273 |
Group (healthy or with pre-eclampsia) | 0.434 | 2.582 | 0.014 |
Variable | Beta Coefficient | Student’s t | Significance Level |
---|---|---|---|
Mother’s age (years) | −0.064 | −0.410 | 0.685 |
BMI (kilograms per square meter) | 0.008 | 0.054 | 0.957 |
CHOL | −0.121 | −0.649 | 0.521 |
AST | −0.105 | −0.322 | 0.750 |
ALT | 0.372 | 1.145 | 0.260 |
Group (healthy or with pre-eclampsia) | 0.439 | 2.463 | 0.019 |
Variable | Test Wald | The Significance Level | Odds Ratio (Confidence Interval) |
---|---|---|---|
Mother’s age (years) | 1.933 | 0.164 | 1.107 (1.278-0.959) |
BMI (kilograms per square meter) | 0.456 | 0.500 | 1.076 (1.330-0.870) |
History of preeclampsia | 0.512 | 0.474 | 0.462 (3.824-0.056) |
CHOL | 1.337 | 0.248 | 1.010 (1.028-0.993) |
AST | 0.441 | 0.507 | 1.048 (1.205-0.912) |
ALT | 1.440 | 0.230 | 0.959 (1.027-0.895) |
Group (healthy or with pre-eclampsia) | 2.677 | 0.102 | 4.754 (30.771-0.735) |
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Memari, B.; Moghiseh, N.; Mohammadian, F.; Ghajarzadeh, M.; Ghoreishian, H. Association of Pre-Eclampsia with Carotid Artery Intima–Media Thickness and Non-Alcoholic Fatty Liver Disease. J. Clin. Med. 2018, 7, 275. https://doi.org/10.3390/jcm7090275
Memari B, Moghiseh N, Mohammadian F, Ghajarzadeh M, Ghoreishian H. Association of Pre-Eclampsia with Carotid Artery Intima–Media Thickness and Non-Alcoholic Fatty Liver Disease. Journal of Clinical Medicine. 2018; 7(9):275. https://doi.org/10.3390/jcm7090275
Chicago/Turabian StyleMemari, Behzad, Niloofar Moghiseh, Farnaz Mohammadian, Mahsa Ghajarzadeh, and Hadi Ghoreishian. 2018. "Association of Pre-Eclampsia with Carotid Artery Intima–Media Thickness and Non-Alcoholic Fatty Liver Disease" Journal of Clinical Medicine 7, no. 9: 275. https://doi.org/10.3390/jcm7090275
APA StyleMemari, B., Moghiseh, N., Mohammadian, F., Ghajarzadeh, M., & Ghoreishian, H. (2018). Association of Pre-Eclampsia with Carotid Artery Intima–Media Thickness and Non-Alcoholic Fatty Liver Disease. Journal of Clinical Medicine, 7(9), 275. https://doi.org/10.3390/jcm7090275