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J. Clin. Med. 2018, 7(9), 265; https://doi.org/10.3390/jcm7090265

Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors

1
Service de Néphrologie Transplantation et Dialyse, Centre Hospitalier Universitaire de Bordeaux, Hôpital Pellegrin, 33076 Bordeaux, France
2
University of Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR1219, 33000 Bordeaux, France
3
INSERM, Clinical Investigation Center-Clinical Epidemiology-CIC-1401, 33000 Bordeaux, France
4
Aurad-Aquitaine, Service Hémodialyse, 2 allée des Demoiselles, 33170 Gradignan, France
5
Laboratoire de Pathologie, Centre Hospitalier Universitaire de Bordeaux, Hôpital Pellegrin, 33076 Bordeaux, France
6
INSERM U1026, Université de Bordeaux, 33000 Bordeaux, France
7
Laboratoire de Cytologie et d’Anatomie Pathologiques de Bordeaux, 30 bis rue Ulysse Gayon, 33000 Bordeaux, France
*
Author to whom correspondence should be addressed.
Received: 16 August 2018 / Revised: 3 September 2018 / Accepted: 7 September 2018 / Published: 9 September 2018
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Abstract

There are various histopathological forms of idiopathic nephrotic syndrome, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Whereas some relapse predictor factors have been identified in renal transplantation, the clinical future of idiopathic nephrotic syndrome in the native kidney remains uncertain. We designed a multicentric retrospective descriptive cohort study including all patients aged 15 years and over whose renal biopsy confirmed MCD or FSGS between January 2007 and December 2014. We studied 165 patients with idiopathic nephrotic syndrome; 97 with MCD and 68 with FSGS. In the MCD cohort, 91.7% of patients were treated with corticosteroids for a median total duration of 13 months. During 45 months of follow-up, 92.8% of patients achieved remission and 45.5% experienced relapse. In this cohort, 5% of patients experienced terminal kidney disease. With respect to FSGS patients, 51.5% were treated with corticosteroids for a median total duration of 15 months. During 66 months of follow-up, 73.5% of patients achieved remission and 20% experienced relapse. In this cohort, 26.5% of patients experienced terminal kidney disease. No statistical association was observed between clinical and biological initial presentation and relapse occurrence. This study describes the characteristics of a cohort of patients with the nephrotic idiopathic syndromes of MCD and FSGS from the time of renal biopsy and throughout follow-up. View Full-Text
Keywords: idiopathic nephrotic syndrome; minimal change disease; focal segmental glomerulosclerosis; relapse; risk factors; complication idiopathic nephrotic syndrome; minimal change disease; focal segmental glomerulosclerosis; relapse; risk factors; complication
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Dumas De La Roque, C.; Prezelin-Reydit, M.; Vermorel, A.; Lepreux, S.; Deminière, C.; Combe, C.; Rigothier, C. Idiopathic Nephrotic Syndrome: Characteristics and Identification of Prognostic Factors. J. Clin. Med. 2018, 7, 265.

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