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Journal of Clinical Medicine, Volume 7, Issue 12

December 2018 - 104 articles

Cover Story: Neutrophils are the most abundant immune cell population in the blood, however their role in the autoimmune neurodegenerative disease multiple sclerosis (MS) remains elusive. The cover image highlights how current disease modifying treatments for MS directly and indirectly target neutrophils. Using evidence extracted from studies with animal models, to clinical trials, this review explores the role neutrophils play in the pathogenesis of MS, and gives a comprehensive overview of how they are affected by current MS treatments. Created with BioRender.View Paper here.
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Articles (104)

  • Article
  • Open Access
4 Citations
3,656 Views
8 Pages

Comparison of Intra-Operative Vital Sign Changes during Total Thyroidectomy in Patients with Controlled and Uncontrolled Graves’ Disease

  • Hyeong Won Yu,
  • In Eui Bae,
  • Su-jin Kim,
  • Young Jun Chai,
  • Jae Hoon Moon,
  • Jung-Hee Ryu,
  • Ah-Young Oh,
  • June Young Choi and
  • Kyu Eun Lee

19 December 2018

Thyroid storm (TS) is a life-threatening emergency endocrine condition. Thyroid hormones should be normalized before thyroidectomy is performed in patients with Graves’ disease. However, thyroid hormone levels are inevitably high in patients undergoi...

  • Review
  • Open Access
89 Citations
9,836 Views
31 Pages

Systematic Review of Variations in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Metastasis from Colorectal Cancer

  • Can Yurttas,
  • Giulia Hoffmann,
  • Alexander Tolios,
  • Sebastian P. Haen,
  • Matthias Schwab,
  • Ingmar Königsrainer,
  • Alfred Königsrainer,
  • Stefan Beckert and
  • Markus W. Löffler

19 December 2018

Background: Cytoreductive surgery (CRS), followed by hyperthermic intraperitoneal chemotherapy (HIPEC), combines radical surgery with abdominal heated chemotherapy, constituting a multimodal treatment approach. Since clear standards for HIPEC conduct...

  • Article
  • Open Access
8 Citations
5,217 Views
13 Pages

Hospitalization Length after Myocardial Infarction: Risk-Assessment-Based Time of Hospital Discharge vs. Real Life Practice

  • Michał Węgiel,
  • Artur Dziewierz,
  • Joanna Wojtasik-Bakalarz,
  • Danuta Sorysz,
  • Andrzej Surdacki,
  • Stanisław Bartuś,
  • Dariusz Dudek and
  • Tomasz Rakowski

18 December 2018

According to guidelines, it is safe for low-risk patients with myocardial infarction (MI) to be discharged within 72 h of hospitalization. However, results coming from registries show that the hospital stay is often much longer in a real-life situati...

  • Review
  • Open Access
29 Citations
8,236 Views
9 Pages

18 December 2018

Prostate-specific antigen (PSA) is currently the most useful biomarker for detection of prostate cancer (PCa). The ability to measure serum PSA levels has affected all aspects of PCa management over the past two decades. The standard initial systemic...

  • Article
  • Open Access
17 Citations
3,767 Views
9 Pages

Fibroblast Growth Factor 23 to Alpha-Klotho Index Correlates with Systemic Sclerosis Activity: A Proposal for Novel Disease Activity Marker

  • Przemyslaw J. Kotyla,
  • Aneta Kruszec-Zytniewska,
  • Aleksander J. Owczarek,
  • Magdalena Olszanecka-Glinianowicz and
  • Jerzy Chudek

17 December 2018

Systemic sclerosis, a connective tissue disease, is characterized by thickening of the skin, massive fibrosis of internal organs, vasculopathy, and immune system functioning aberration. Recently, vitamin D (VD) deficit, seen almost universally in pat...

  • Article
  • Open Access
22 Citations
5,114 Views
19 Pages

Pre-Operative Frailty Status Is Associated with Cardiac Rehabilitation Completion: A Retrospective Cohort Study

  • Dustin E. Kimber,
  • D. Scott Kehler,
  • James Lytwyn,
  • Kevin F. Boreskie,
  • Patrick Jung,
  • Bryce Alexander,
  • Brett M. Hiebert,
  • Chris Dubiel,
  • Naomi C. Hamm and
  • Andrew N. Stammers
  • + 7 authors

17 December 2018

While previous investigations have demonstrated the benefit of cardiac rehabilitation (CR) on outcomes after cardiac surgery, the association between pre-operative frailty and post-operative CR completion is unclear. The purpose of this retrospective...

  • Article
  • Open Access
13 Citations
3,384 Views
8 Pages

17 December 2018

Background: The purpose of this prospective study was to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for assessing treatment response in patients with pulmonary multidrug-resistant t...

  • Article
  • Open Access
42 Citations
5,664 Views
14 Pages

Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults

  • Fanny Buckinx,
  • Gilles Gouspillou,
  • Livia P. Carvalho,
  • Vincent Marcangeli,
  • Guy El Hajj Boutros,
  • Maude Dulac,
  • Philippe Noirez,
  • José A. Morais,
  • Pierette Gaudreau and
  • Mylène Aubertin-Leheudre

17 December 2018

Background: To compare the effects of high-intensity interval training (HIIT) alone vs. HIIT combined with L-citrulline (CIT) supplementation on functional capacity and muscle function in dynapenic-obese elderly. Methods: A total of 56 obese (fat mas...

  • Article
  • Open Access
91 Citations
5,891 Views
12 Pages

Lean Patients with Non-Alcoholic Fatty Liver Disease Have a Severe Histological Phenotype Similar to Obese Patients

  • Lukas Denkmayr,
  • Alexandra Feldman,
  • Lars Stechemesser,
  • Sebastian K. Eder,
  • Stephan Zandanell,
  • Michael Schranz,
  • Michael Strasser,
  • Ursula Huber-Schönauer,
  • Stephan Buch and
  • Jochen Hampe
  • + 6 authors

17 December 2018

A small proportion of lean patients develop non-alcoholic fatty liver disease (NAFLD). We aimed to report the histological picture of lean NAFLD in comparison to overweight and obese NAFLD patients. Biopsy and clinical data from 466 patients diagnose...

  • Article
  • Open Access
27 Citations
6,255 Views
25 Pages

17 December 2018

Bacterial peptide deformylase (PDF) is an attractive target for developing novel inhibitors against several types of multidrug-resistant bacteria. The objective of the current study is to retrieve potential phytochemicals as prospective drugs against...

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J. Clin. Med. - ISSN 2077-0383