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The Emerging Role of Neutrophil Granulocytes in Multiple Sclerosis

The John Curtin School of Medical Research, The Australian National University, Canberra 2600, Australia
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Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(12), 511; https://doi.org/10.3390/jcm7120511
Received: 2 November 2018 / Revised: 26 November 2018 / Accepted: 29 November 2018 / Published: 3 December 2018
(This article belongs to the Special Issue Potential Pathogenic Mechanisms of Multiple Sclerosis)
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a strong autoimmune, neurodegenerative, and neuroinflammatory component. Most of the common disease modifying treatments (DMTs) for MS modulate the immune response targeting disease associated T and B cells and while none directly target neutrophils, several DMTs do impact their abundance or function. The role of neutrophils in MS remains unknown and research is ongoing to better understand the phenotype, function, and contribution of neutrophils to both disease onset and stage of disease. Here we summarize the current state of knowledge of neutrophils and their function in MS, including in the rodent based MS model, and we discuss the potential effects of current treatments on these functions. We propose that neutrophils are likely to participate in MS pathogenesis and their abundance and function warrant monitoring in MS. View Full-Text
Keywords: multiple sclerosis; neutrophils; NETs; EAE; treatment multiple sclerosis; neutrophils; NETs; EAE; treatment
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MDPI and ACS Style

Woodberry, T.; Bouffler, S.E.; Wilson, A.S.; Buckland, R.L.; Brüstle, A. The Emerging Role of Neutrophil Granulocytes in Multiple Sclerosis. J. Clin. Med. 2018, 7, 511.

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