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J. Clin. Med. 2018, 7(12), 561; https://doi.org/10.3390/jcm7120561

Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults

1
Département des Sciences de l’activité physique, Groupe de Recherche en Activité Physique Adaptée (GRAPA), Université du Québec à Montréal, Montréal, QC H2X 1Y4, Canada
2
Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal (CRIUGM), Montréal, QC H3W 1W6, Canada
3
Institut de Recherche bioMédicale et d’Épidémiologie du Sport (IRMES), Université Paris Descartes, Sorbonne Paris Cité, 75012 Paris, France
4
Division of Geriatric Medicine, McGill University Health Centre (MUHC), McGill University, Montréal, QC H3A 1A1, Canada
5
Département de Médecine de l’Université de Montréal, Centre de Recherche du Centre Hospitalier Universitaire de Montréal (CRCHUM), Université de Montréal, Montréal, QC H2X 3E4, Canada
*
Author to whom correspondence should be addressed.
Received: 5 November 2018 / Revised: 11 December 2018 / Accepted: 12 December 2018 / Published: 17 December 2018
(This article belongs to the Special Issue Sarcopenia in Older Adults)
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Abstract

Background: To compare the effects of high-intensity interval training (HIIT) alone vs. HIIT combined with L-citrulline (CIT) supplementation on functional capacity and muscle function in dynapenic-obese elderly. Methods: A total of 56 obese (fat mass: men > 25%, women > 35%) and dynapenic (grip strength/body weight: women < 0.44, men < 0.61) subjects were recruited and divided in two groups: HIIT+CIT (n = 26; age: 6 5 ± four years) vs. HIIT+Placebo (PLA, n = 30; age: 68 ± four years). Participants followed a 12-week HIIT using an elliptical trainer. Participants took a single and isocaloric 10 g-dose of CIT or PLA every day. Body composition; functional and aerobic capacities; absolute or relative upper and lower limbs muscle strength, muscle power; and energy balance were measured pre and post intervention. Results: Both groups significantly improved functional capacity and muscle function. However, HIIT+CIT demonstrated greater improvements in fast-paced Timed Up & Go (p = 0.04) and upper limbs muscle strength (absolute and relative) (p = 0.05) than HIIT+Placebo. Conclusion: CIT supplementation when combined with HIIT seems to induce greater improvements in upper limbs muscle strength and walking speed in dynapenic-obese elderly. Further studies are needed to confirm our results, to elucidate the mechanisms underlying the beneficial effects of CIT and to define the long-term impact of CIT/HIIT. View Full-Text
Keywords: HIIT; citrulline; dynapenia; obesity; functional capacities; muscle function; aging HIIT; citrulline; dynapenia; obesity; functional capacities; muscle function; aging
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Buckinx, F.; Gouspillou, G.; Carvalho, L.P.; Marcangeli, V.; El Hajj Boutros, G.; Dulac, M.; Noirez, P.; Morais, J.A.; Gaudreau, P.; Aubertin-Leheudre, M. Effect of High-Intensity Interval Training Combined with L-Citrulline Supplementation on Functional Capacities and Muscle Function in Dynapenic-Obese Older Adults. J. Clin. Med. 2018, 7, 561.

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