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Vaccines, Volume 12, Issue 1

January 2024 - 108 articles

Cover Story: The DNA (deoxyribonucleic acid) vaccine, a gene vaccine, works by harnessing host cell machinery to produce a peptide antigen capable of generating an immune response leading to the development of durable immunity. The development requires the sequencing of a target antigen gene. The gene is synthesized and loaded into a vector, commonly either a bacterial plasmid or a viral vector. The vector system can be further engineered by adding specific molecules to enhance cellular uptake and nuclear translocation. The site and route of delivery are chosen according to targeted cell populations and immunostimulatory features. The host cell’s native machinery transcribes and translates the delivered DNA and generates an antigen product, which is then presented to immune cells. The result is a robust innate and subsequent adaptive immune response leading to the formation of immunological memory. View this paper
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Articles (108)

  • Communication
  • Open Access
1 Citations
2,013 Views
7 Pages

18 January 2024

With the worldwide spread of SARS-CoV-2 disease, people with cystic fibrosis (CF), especially solid organ transplant recipients, have quickly been identified as a risk group for severe disease. Studies have shown low antibody response to SARS-CoV-2 v...

  • Review
  • Open Access
20 Citations
18,850 Views
27 Pages

18 January 2024

Respiratory Syncytial Virus (RSV) poses a significant global health concern as a major cause of lower respiratory tract infections (LRTIs). Over the last few years, substantial efforts have been directed towards developing vaccines and therapeutics t...

  • Article
  • Open Access
2 Citations
5,342 Views
15 Pages

18 January 2024

In North America, range constraints due to burgeoning development increasingly encroach on wild horse habitat and necessitate effective but humane reproductive management. The largest free-roaming wild horse fertility control program by population (&...

  • Article
  • Open Access
6 Citations
3,197 Views
24 Pages

Development of Cross-Reactive Live Attenuated Influenza Vaccine Candidates against Both Lineages of Influenza B Virus

  • Pei-Fong Wong,
  • Irina Isakova-Sivak,
  • Ekaterina Stepanova,
  • Elena Krutikova,
  • Ekaterina Bazhenova,
  • Andrey Rekstin and
  • Larisa Rudenko

18 January 2024

Background: Influenza viruses continue to cause a significant social and economic burden globally. Vaccination is recognized as the most effective measure to control influenza. Live attenuated influenza vaccines (LAIVs) are an effective means of prev...

  • Brief Report
  • Open Access
4 Citations
1,950 Views
10 Pages

Measuring Variant-Specific Neutralizing Antibody Profiles after Bivalent SARS-CoV-2 Vaccinations Using a Multivariant Surrogate Virus Neutralization Microarray

  • David Niklas Springer,
  • Eva Höltl,
  • Katja Prüger,
  • Elisabeth Puchhammer-Stöckl,
  • Judith Helene Aberle,
  • Karin Stiasny and
  • Lukas Weseslindtner

18 January 2024

The capability of antibodies to neutralize different SARS-CoV-2 variants varies among individuals depending on the previous exposure to wild-type or Omicron-specific immunogens by mono- or bivalent vaccinations or infections. Such profiles of neutral...

  • Article
  • Open Access
3 Citations
2,588 Views
11 Pages

Factors Associated with the Implementation of Pediatric Immunization Services: A Survey of Community Pharmacies

  • Oluchukwu M. Ezeala,
  • Nicholas P. McCormick,
  • Christopher L. Meininger,
  • Spencer H. Durham,
  • Tessa J. Hastings and
  • Salisa C. Westrick

18 January 2024

Pharmacists are well-positioned to help increase pediatric immunization rates. This study assessed the types of pediatric vaccines offered in community pharmacies, compared participant/pharmacy characteristics and participants’ perceptions of b...

  • Article
  • Open Access
3 Citations
3,834 Views
13 Pages

Harnessing Pentameric Scaffold of Cholera Toxin B (CTB) for Design of Subvirion Recombinant Dengue Virus Vaccine

  • Jemin Sung,
  • Yucheol Cheong,
  • Young-Seok Kim,
  • Jina Ahn,
  • Myung Hyun Sohn,
  • Sanguine Byun and
  • Baik-Lin Seong

17 January 2024

Dengue virus is an enveloped virus with an icosahedral assembly of envelope proteins (E). The E proteins are arranged as a head-to-tail homodimer, and domain III (EDIII) is placed at the edge of the dimer, converging to a pentamer interface. For a st...

  • Article
  • Open Access
2 Citations
2,310 Views
16 Pages

Differences in Responses of Immunosuppressed Kidney Transplant Patients to Moderna mRNA-1273 versus Pfizer-BioNTech

  • Dulat Bekbolsynov,
  • Andrew Waack,
  • Camryn Buskey,
  • Shalmali Bhadkamkar,
  • Keegan Rengel,
  • Winnifer Petersen,
  • Mary Lee Brown,
  • Tanaya Sparkle,
  • Dinkar Kaw and
  • Fayeq Jeelani Syed
  • + 6 authors

17 January 2024

Immunosuppressed kidney transplant (KT) recipients produce a weaker response to COVID-19 vaccination than immunocompetent individuals. We tested antiviral IgG response in 99 KT recipients and 66 healthy volunteers who were vaccinated with mRNA-1273 M...

  • Brief Report
  • Open Access
1,983 Views
9 Pages

Endemic Human Coronavirus-Specific Nasal Immunoglobulin A and Serum Immunoglobulin G Dynamics in Lower Respiratory Tract Infections

  • Ferdyansyah Sechan,
  • Katherine Loens,
  • Herman Goossens,
  • Margareta Ieven and
  • Lia van der Hoek

17 January 2024

Endemic human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 cause respiratory infection. Following infection, a virus-specific serum antibody rise is usually observed, coinciding with recovery. In some cases, an infection is not accompanied by an i...

  • Article
  • Open Access
7 Citations
5,135 Views
15 Pages

A Holistic Strategy of Mother and Child Health Care to Improve the Coverage of Routine and Polio Immunization in Pakistan: Results from a Demonstration Project

  • Muhammad Atif Habib,
  • Sajid Bashir Soofi,
  • Zamir Hussain,
  • Imran Ahmed,
  • Rehman Tahir,
  • Saeed Anwar,
  • Ahmed Ali Nauman,
  • Muhammad Sharif,
  • Muhammad Islam and
  • Simon Cousens
  • + 1 author

16 January 2024

Background: The eradication of poliovirus and improving routine immunization (RI) coverage rates present significant challenges in Pakistan. There is a need for interventions that focus on strengthening community engagement to improve routine immuniz...

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Vaccines - ISSN 2076-393X