Special Issue "Clinical and Preclinical Development of Bacterial Vaccines"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Attenuated/Inactivated/Live and Vectored Vaccines".

Deadline for manuscript submissions: 10 September 2023 | Viewed by 1551

Special Issue Editors

Center for Immunobiology, WMU Homer Stryker MD School of Medicine, Kalamazoo, MI 49007-7000, USA
Interests: B cells immunobiology; innate immunity; B1 B cells; natural antibodies; B cell receptor signaling
Special Issues, Collections and Topics in MDPI journals
Institute for Systems Biology, University of Washington, Seattle, WA 98109, USA
Interests: microbial pathogenesis; innate immunity; inflammation; host-pathogen interaction; autoinflammatory disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global threat of antimicrobial resistance (AMR) has been identified by the World Health Organization as one of the three greatest threats to human health; annual deaths related to AMR are currently ~700,000, and are projected to rise to 10 million by 2050. New antibiotics cannot solve the problem, as bacteria quickly adapt and develop new resistance mechanisms. Therefore, there is an urgent need for the development of vaccines against AMR. Bacterial vaccines are used for managing bacterial diseases. They reduce the incidence of resistant and susceptible infections, as well as antibiotic consumption. Advances in vaccine technology in recent decades have made it possible to develop vaccines against previously challenging targets. There is a need to understand which vaccines are currently being developed and which may serve as tools to help control AMR in the future.

The aim of this Special Issue is to investigate bacterial vaccine candidates in preclinical and clinical development against pathogens, some of the main advances made, new techniques and methods for vaccine development, and vaccine benefits and drawbacks.

Dr. Naeem Khan
Dr. Ajay S. Akhade
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • clinical and preclinical vaccine design
  • types of vaccines
  • adjuvant
  • delivery
  • safety

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Article
Cost-Effectiveness Analysis of Routine Use of 15-Valent Pneumococcal Conjugate Vaccine in the US Pediatric Population
Vaccines 2023, 11(1), 135; https://doi.org/10.3390/vaccines11010135 - 06 Jan 2023
Viewed by 1339
Abstract
This study evaluated the clinical and economic impact of routine pediatric vaccination with the 15-valent pneumococcal conjugate vaccine (PCV15, V114) compared with the 13-valent PCV (PCV13) from a societal perspective in the United States (US). A Markov decision-analytic model was constructed to estimate [...] Read more.
This study evaluated the clinical and economic impact of routine pediatric vaccination with the 15-valent pneumococcal conjugate vaccine (PCV15, V114) compared with the 13-valent PCV (PCV13) from a societal perspective in the United States (US). A Markov decision-analytic model was constructed to estimate the outcomes for the entire US population over a 100-year time horizon. The model estimated the impact of V114 versus PCV13 on pneumococcal disease (PD) incidence, post meningitis sequalae, and deaths, taking herd immunity effects into account. V114 effectiveness was extrapolated from the observed PCV13 data and PCV7 clinical trials. Costs (2021$) included vaccine acquisition and administration costs, direct medical costs for PD treatment, direct non-medical costs, and indirect costs, and were discounted at 3% per year. In the base case, V114 prevented 185,711 additional invasive pneumococcal disease, 987,727 all-cause pneumonia, and 11.2 million pneumococcal acute otitis media cases, compared with PCV13. This led to expected gains of 90,026 life years and 96,056 quality-adjusted life years with a total saving of $10.8 billion. Sensitivity analysis showed consistent results over plausible values of key model inputs and assumptions. The findings suggest that V114 is a cost-saving option compared to PCV13 in the routine pediatric vaccination program. Full article
(This article belongs to the Special Issue Clinical and Preclinical Development of Bacterial Vaccines)
Show Figures

Figure 1

Back to TopTop