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Vaccines, Volume 12, Issue 1

January 2024 - 108 articles

Cover Story: The DNA (deoxyribonucleic acid) vaccine, a gene vaccine, works by harnessing host cell machinery to produce a peptide antigen capable of generating an immune response leading to the development of durable immunity. The development requires the sequencing of a target antigen gene. The gene is synthesized and loaded into a vector, commonly either a bacterial plasmid or a viral vector. The vector system can be further engineered by adding specific molecules to enhance cellular uptake and nuclear translocation. The site and route of delivery are chosen according to targeted cell populations and immunostimulatory features. The host cell’s native machinery transcribes and translates the delivered DNA and generates an antigen product, which is then presented to immune cells. The result is a robust innate and subsequent adaptive immune response leading to the formation of immunological memory. View this paper
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Articles (108)

  • Article
  • Open Access
1 Citations
3,931 Views
17 Pages

Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model

  • Kyu-Ri Kang,
  • Ji-Ahn Kim,
  • Gyu-Won Cho,
  • Han-Ul Kang,
  • Hyun-Mi Kang,
  • Jin-Han Kang,
  • Baik-Lin Seong and
  • Soo-Young Lee

22 January 2024

Since the 2000s, sporadic outbreaks of whooping cough have been reported in advanced countries, where the acellular pertussis vaccination rate is relatively high, and in developing countries. Small-scale whooping cough has also continued in many coun...

  • Article
  • Open Access
10 Citations
6,896 Views
13 Pages

Suboptimal MMR Vaccination Coverages—A Constant Challenge for Measles Elimination in Romania

  • Aurora Stanescu,
  • Simona Maria Ruta,
  • Costin Cernescu and
  • Adriana Pistol

22 January 2024

Measles is targeted for elimination since 2001, with a significant reduction in cases recorded worldwide, but outbreaks occur periodically due to immunization gaps. This study analyzes the evolution of vaccination coverage rates (VCRs) in Romania, a...

  • Article
  • Open Access
3 Citations
2,793 Views
17 Pages

Effects of G and SH Truncation on the Replication, Virulence, and Immunogenicity of Avian Metapneumovirus

  • Seung-Min Hong,
  • Eun-Jin Ha,
  • Ho-Won Kim,
  • Seung-Ji Kim,
  • Sun-Min Ahn,
  • Se-Hee An,
  • Gun Kim,
  • Suji Kim,
  • Hyuk-Joon Kwon and
  • Kang-Seuk Choi

21 January 2024

Four mutants varying the length of the G and SH genes, including a G-truncated mutant (ΔG) and three G/SH-truncated mutants (ΔSH/G-1, ΔSH/G-2, and ΔSH/G-3), were generated via serially passaging the avian metapneumovirus strai...

  • Brief Report
  • Open Access
3 Citations
2,871 Views
11 Pages

Immunity to Tick-Borne Encephalitis Virus NS3 Protein Induced with a Recombinant Modified Vaccinia Virus Ankara Fails to Afford Mice Protection against TBEV Infection

  • Mareike Kubinski,
  • Jana Beicht,
  • Thomas Gerlach,
  • Amare Aregay,
  • Albert D. M. E. Osterhaus,
  • Alina Tscherne,
  • Gerd Sutter,
  • Chittappen Kandiyil Prajeeth and
  • Guus F. Rimmelzwaan

20 January 2024

Tick-borne encephalitis (TBE) is a serious neurological disease caused by TBE virus (TBEV). Because antiviral treatment options are not available, vaccination is the key prophylactic measure against TBEV infections. Despite the availability of effect...

  • Article
  • Open Access
1 Citations
3,198 Views
22 Pages

Association of the Magnitude of Anti-SARS-CoV-2 Vaccine Side Effects with Sex, Allergy History, Chronic Diseases, Medication Intake, and SARS-CoV-2 Infection

  • Elias A. Said,
  • Afnan Al-Rubkhi,
  • Sanjay Jaju,
  • Crystal Y. Koh,
  • Mohammed S. Al-Balushi,
  • Khalid Al-Naamani,
  • Siham Al-Sinani,
  • Juma Z. Al-Busaidi and
  • Ali A. Al-Jabri

20 January 2024

Vaccination provides the best protection against the increasing infections of SARS-CoV-2. The magnitude and type of anti-SARS-CoV-2 vaccine side effects (SEs) depend on parameters that are not fully understood. In this cross-sectional study, the asso...

  • Article
  • Open Access
5 Citations
3,627 Views
16 Pages

Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population

  • Marta C. Cruz Cisneros,
  • Elizabeth J. Anderson,
  • Brea K. Hampton,
  • Breantié Parotti,
  • Sanjay Sarkar,
  • Sharon Taft-Benz,
  • Timothy A. Bell,
  • Matthew Blanchard,
  • Jacob A. Dillard and
  • Kenneth H. Dinnon
  • + 10 authors

20 January 2024

The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral variants, host age,...

  • Systematic Review
  • Open Access
3 Citations
4,414 Views
14 Pages

19 January 2024

During the coronavirus diseases 2019 (COVID-19) pandemic, the safety and efficacy of vaccination during pregnancy, particularly regarding the risk of preterm birth, have been a subject of concern. This systematic review aims to evaluate the impact of...

  • Article
  • Open Access
2,706 Views
12 Pages

Toxoplasma gondii eIF-5A Modulates the Immune Response of Murine Macrophages In Vitro

  • Xinchao Liu,
  • Xiaoyu Li,
  • Chunjing Li,
  • Mingmin Lu,
  • Lixin Xu,
  • Ruofeng Yan,
  • Xiaokai Song and
  • Xiangrui Li

19 January 2024

Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan that can elicit a robust immune response during infection. Macrophage cells have been shown to play an important role in the immune response against T. gondii. In our previous study...

  • Article
  • Open Access
3 Citations
2,820 Views
19 Pages

Safety and Immunogenicity of the Convacell® Recombinant N Protein COVID-19 Vaccine

  • Sevastyan Rabdano,
  • Ellina Ruzanova,
  • Denis Makarov,
  • Anastasiya Vertyachikh,
  • Valeriya Teplykh,
  • German Rudakov,
  • Iuliia Pletyukhina,
  • Nikita Saveliev,
  • Konstantin Zakharov and
  • Diana Alpenidze
  • + 3 authors

19 January 2024

We have developed Convacell®—a COVID-19 vaccine based on the recombinant nucleocapsid (N) protein of SARS-CoV-2. This paper details Convacell’s® combined phase I/II and IIb randomized, double-blind, interventional clinical trials....

  • Article
  • Open Access
19 Citations
6,631 Views
13 Pages

Prevalence and Factors Associated with Long COVID Symptoms among U.S. Adults, 2022

  • Kimberly H. Nguyen,
  • Yingjun Bao,
  • Julie Mortazavi,
  • Jennifer D. Allen,
  • Patricia O. Chocano-Bedoya and
  • Laura Corlin

18 January 2024

Long COVID and its symptoms have not been examined in different subpopulations of U.S. adults. Using the 2022 BRFSS (n = 445,132), we assessed long COVID and each symptom by sociodemographic characteristics and health-related variables. Multivariable...

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Vaccines - ISSN 2076-393X