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Vaccines, Volume 11, Issue 9

September 2023 - 117 articles

Cover Story: Group B streptococcus (GBS) is a leading cause of life-threatening neonatal infections and adverse pregnancy outcomes. It is classified into 10 different serotypes based on the capsular polysaccharide (CPS). No effective vaccine is clinically available. In this study by Wang et al., six conserved virulence factors involved in GBS pathogenesis at different stages were formulated as the GBSV6 vaccine. Intranasal GBSV6 immunization (i.n.) induced systemic and vaginal antibodies and T cell responses in mice. The immunity reduced mouse mortality and vaginal colonization by various GBS serotypes and protected newborns of immunized dams against the GBS challenge. The findings indicate that i.n. immunization targeting multiple conserved GBS virulence factors induces serotype-independent immunity, which protects against GBS infection systemically and vaginally in dams and prevents newborn deaths. View this paper
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Articles (117)

  • Article
  • Open Access
3 Citations
1,773 Views
12 Pages

Attitudes and Practices Related to COVID-19 Vaccination with the Second Booster Dose among Members of Athens Medical Association: Results from a Cross-Sectional Study

  • Georgios Zoumpoulis,
  • Paraskevi Deligiorgi,
  • Dimitrios Lamprinos,
  • Panagiotis Georgakopoulos,
  • Evangelos Oikonomou,
  • Gerasimos Siasos,
  • Georgios Rachiotis,
  • Christos Damaskos,
  • Dimitrios Papagiannis and
  • Kostas A. Papavassiliou
  • + 7 authors

12 September 2023

Background: There are limited data on the attitudes and acceptance of the second booster (fourth dose) of the COVID-19 vaccination among physicians. Methods: A cross-sectional, questionnaire-based, online study was conducted among members of the Athe...

  • Article
  • Open Access
5 Citations
3,381 Views
11 Pages

Intranasal HBsAg/HBcAg-Containing Vaccine Induces Neutralizing Anti-HBs Production in Hepatitis B Vaccine Non-Responders

  • Kana Shiraishi,
  • Osamu Yoshida,
  • Yusuke Imai,
  • Sheikh Mohammad Fazle Akbar,
  • Takahiro Sanada,
  • Michinori Kohara,
  • Takashi Miyazaki,
  • Taizou Kamishita,
  • Teruki Miyake and
  • Masashi Hirooka
  • + 5 authors

12 September 2023

Hepatitis B vaccine induces the production of antibodies against hepatitis B surface antigen (anti-HBs) and prevents hepatitis B virus (HBV) infection. However, 5–10% of individuals cannot develop anti-HBs even after multiple vaccinations (HB vaccine...

  • Article
  • Open Access
8 Citations
2,350 Views
12 Pages

Influenza Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Cases and Hospitalizations in Navarre, Spain, 2022–2023

  • Iván Martínez-Baz,
  • Miguel Fernández-Huerta,
  • Ana Navascués,
  • Francisco Pozo,
  • Camino Trobajo-Sanmartín,
  • Itziar Casado,
  • Aitziber Echeverria,
  • Carmen Ezpeleta and
  • Jesús Castilla

12 September 2023

We estimated influenza vaccine effectiveness (IVE) in preventing outpatient and hospitalized cases in the 2022–2023 season. A test-negative design included a representative sample of outpatients and all hospitalized patients with influenza-like...

  • Article
  • Open Access
6 Citations
1,997 Views
14 Pages

Clinical and Molecular Epidemiology of Hemorrhagic Fever with Renal Syndrome Caused by Orthohantaviruses in Xiangyun County, Dali Prefecture, Yunnan Province, China

  • Hao Huang,
  • Meng Fu,
  • Peiyu Han,
  • Hongmin Yin,
  • Zi Yang,
  • Yichen Kong,
  • Bo Wang,
  • Xinglou Yang,
  • Tilian Ren and
  • Yunzhi Zhang

12 September 2023

Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease transmitted by several rodent species. We obtained clinical data of HFRS patients from the medical records of the People’s Hospital of Xiangyun County in Dali Prefecture from Ju...

  • Article
  • Open Access
9 Citations
2,518 Views
20 Pages

11 September 2023

Infectious diseases pose significant public health risks, necessitating effective control strategies. One such strategy is implementing a voluntary vaccination policy, which grants individuals the autonomy to make their own decisions regarding vaccin...

  • Article
  • Open Access
12 Citations
3,021 Views
11 Pages

11 September 2023

Cell-mediated immunity (CMI) plays a key role in the effectiveness of varicella zoster virus (VZV) vaccines, and mRNA vaccines have an innate advantage in inducing CMI. Glycoprotein E (gE) has been used widely as an antigen for VZV vaccines, and carb...

  • Article
  • Open Access
1 Citations
1,848 Views
13 Pages

11 September 2023

Lymphocyte apoptosis plays a crucial role in tumor-induced immunosuppression. Programmed death ligand-1 (PD-L1) blocks lymphocyte activation via its receptor, PD-1. However, PD-L1/PD-1 expression and its role in enhancing immune suppression in non-Ho...

  • Article
  • Open Access
6 Citations
3,335 Views
12 Pages

10 September 2023

Clostridium botulinum serotypes C and D cause botulism in livestock, a neuroparalytic disease that results in substantial economic losses. Vaccination with aluminium-based toxoid vaccines is widely used to control the spread of botulism. Aluminium-ba...

  • Review
  • Open Access
9 Citations
2,283 Views
16 Pages

10 September 2023

Coronavirus disease 2019 (COVID-19) is a worldwide public health and economic threat, and virus variation amplifies the difficulty in epidemic prevention and control. The structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has b...

  • Article
  • Open Access
4 Citations
2,481 Views
15 Pages

Understanding COVID-19 Vaccine Acceptance among Latin American Health Workers: Implications for Designing Interventions

  • Tamara Rivera,
  • Jennifer Brustrom,
  • Maite Vera Antelo,
  • E. Benjamin Puertas,
  • Dale A. Rhoda and
  • Martha Velandia-Gonzalez

10 September 2023

Health workers (HWs) have a key role in promoting vaccine acceptance. This study draws on the Behavioral and Social Drivers of Vaccination (BeSD) model and our team’s investigation of vaccine hesitancy in a sample of 1197 HWs across 14 Caribbea...

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Vaccines - ISSN 2076-393X