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Vaccines, Volume 11, Issue 9

September 2023 - 117 articles

Cover Story: Group B streptococcus (GBS) is a leading cause of life-threatening neonatal infections and adverse pregnancy outcomes. It is classified into 10 different serotypes based on the capsular polysaccharide (CPS). No effective vaccine is clinically available. In this study by Wang et al., six conserved virulence factors involved in GBS pathogenesis at different stages were formulated as the GBSV6 vaccine. Intranasal GBSV6 immunization (i.n.) induced systemic and vaginal antibodies and T cell responses in mice. The immunity reduced mouse mortality and vaginal colonization by various GBS serotypes and protected newborns of immunized dams against the GBS challenge. The findings indicate that i.n. immunization targeting multiple conserved GBS virulence factors induces serotype-independent immunity, which protects against GBS infection systemically and vaginally in dams and prevents newborn deaths. View this paper
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Articles (117)

  • Review
  • Open Access
9 Citations
4,366 Views
36 Pages

15 September 2023

Vaccination plays a crucial role in combating the global COVID-19 pandemic. Immunizing all healthcare workers (HCWs) is essential for increasing vaccine confidence and acceptance within the general population. Understanding the factors that hinder or...

  • Article
  • Open Access
2,059 Views
12 Pages

14 September 2023

Background: In developing countries, access to information, awareness, and availability of COVID-19 vaccines are key challenges. Somalia launched the COVID-19 vaccination in March 2021; however, the uptake of the vaccination is slow, which creates fe...

  • Article
  • Open Access
8 Citations
2,634 Views
28 Pages

Combinatorial Effects of miRNAs in HSV-2 Infection of Macrophages: An In Silico and In Vitro Integration Approach

  • Anwesha Banerjee,
  • Debashree Dass,
  • Kishore Dhotre,
  • Pooja Wakchoure,
  • Ashwini More,
  • Santanu Rana,
  • Abdul A. Khan and
  • Anupam Mukherjee

14 September 2023

The rising issues of herpes simplex virus (HSV)-2 drug ramifications have encouraged the researchers to look for new and alternative approaches that pose minimum adversities in the host while efficiently reducing the HSV-2 infection. Although microRN...

  • Article
  • Open Access
2 Citations
2,250 Views
15 Pages

Serological Conversion through a Second Exposure to Inactivated Foot-and-Mouth Disease Virus Expressing the JC Epitope on the Viral Surface

  • Seong Yun Hwang,
  • Sung Ho Shin,
  • Sung-Han Park,
  • Min Ja Lee,
  • Su-Mi Kim,
  • Jong-Soo Lee and
  • Jong-Hyeon Park

14 September 2023

Foot-and-mouth disease (FMD) is a fatal contagious viral disease that affects cloven-hoofed animals and causes severe economic damage at the national level. There are seven serotypes of the causative foot-and-mouth disease virus (FMDV), and type O is...

  • Article
  • Open Access
2 Citations
3,073 Views
18 Pages

CD4+ T Cell Responses to Toxoplasma gondii Are a Double-Edged Sword

  • Kamal El Bissati,
  • Paulette A. Krishack,
  • Ying Zhou,
  • Christopher R. Weber,
  • Joseph Lykins,
  • Dragana Jankovic,
  • Karen L. Edelblum,
  • Laura Fraczek,
  • Harshita Grover and
  • Aziz A. Chentoufi
  • + 9 authors

14 September 2023

CD4+ T cells have been found to play critical roles in the control of both acute and chronic Toxoplasma infection. Previous studies identified a protective role for the Toxoplasma CD4+ T cell-eliciting peptide AS15 (AVEIHRPVPGTAPPS) in C57BL/6J mice....

  • Systematic Review
  • Open Access
10 Citations
3,401 Views
17 Pages

Acceptability of HPV Vaccines: A Qualitative Systematic Review and Meta-Summary

  • María-Teresa Urrutia,
  • Alejandra-Ximena Araya,
  • Macarena Gajardo,
  • Macarena Chepo,
  • Romina Torres and
  • Andrea Schilling

14 September 2023

In 2006, the human papillomavirus (HPV) vaccine was approved for use as an effective intervention for reducing the risk of developing cervical cancer; however, its successful implementation is dependent on acceptability. This study aims to provide a...

  • Systematic Review
  • Open Access
4 Citations
3,097 Views
11 Pages

Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review

  • Sara Boccalini,
  • Benedetta Bonito,
  • Cristina Salvati,
  • Marco Del Riccio,
  • Enrica Stancanelli,
  • Mario Bruschi,
  • Giulia Ionita,
  • Johanna Iamarino,
  • Davide Bentivegna and
  • Primo Buscemi
  • + 12 authors

14 September 2023

Background: Human respiratory syncytial virus (hRSV) is a key contributor to lower respiratory tract infections (LRTIs), affecting children aged 0–5 years and often leading to outpatient visits, emergency department utilization, and hospitaliza...

  • Article
  • Open Access
2,190 Views
14 Pages

Safety of the Administration of an Inactivated PCV2a/PCV2b/Mycoplasma Hyopneumoniae Vaccine to Pregnant and Lactating Sows and Gilts

  • Elena Pérez,
  • Cristina Venegas-Vargas,
  • Andrea Heinz,
  • Megan Smutzer,
  • Lucas P. Taylor,
  • Yvette Diamondidis,
  • Nevena Mangarova,
  • Tara Hansen,
  • José Angulo and
  • Meggan Bandrick
  • + 1 author

14 September 2023

Porcine Circovirus type 2 (PCV2) vaccination of gilts during acclimation has become a routine practice in commercial pig farms to homogenize herd immunity to PCV2 and reduce the impact of diseases associated with PCV2 infection, namely reproductive,...

  • Article
  • Open Access
7 Citations
5,825 Views
14 Pages

Respiratory Syncytial Virus Infections in Polish Pediatric Patients from an Expert Perspective

  • Maria K. Borszewska-Kornacka,
  • Agnieszka Mastalerz-Migas,
  • Aneta Nitsch-Osuch,
  • Teresa Jackowska,
  • Iwona Paradowska-Stankiewicz,
  • Ernest Kuchar,
  • Jan Mazela,
  • Ewa Helwich,
  • Marcin Czech and
  • Ryszard Lauterbach
  • + 3 authors

13 September 2023

Respiratory syncytial virus (RSV) is the most common pathogen causing respiratory tract infections in infants, affecting over 90% of children within the first two years of life. It may cause lower respiratory tract infections, which constitute a sign...

  • Review
  • Open Access
5 Citations
5,445 Views
29 Pages

Updated Considerations for the Immunopharmacological Aspects of the “Talented mRNA Vaccines”

  • Cristiana Perrotta,
  • Claudio Fenizia,
  • Carla Carnovale,
  • Marco Pozzi,
  • Daria Trabattoni,
  • Davide Cervia and
  • Emilio Clementi

12 September 2023

Messenger RNA (mRNA) vaccines belong to a new class of medications, RNA therapeutics, including both coding and non-coding RNAs. The use of mRNA as a therapy is based on the biological role of mRNA itself, namely its translation into a functional pro...

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Vaccines - ISSN 2076-393X