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Vaccines, Volume 11, Issue 9

September 2023 - 117 articles

Cover Story: Group B streptococcus (GBS) is a leading cause of life-threatening neonatal infections and adverse pregnancy outcomes. It is classified into 10 different serotypes based on the capsular polysaccharide (CPS). No effective vaccine is clinically available. In this study by Wang et al., six conserved virulence factors involved in GBS pathogenesis at different stages were formulated as the GBSV6 vaccine. Intranasal GBSV6 immunization (i.n.) induced systemic and vaginal antibodies and T cell responses in mice. The immunity reduced mouse mortality and vaginal colonization by various GBS serotypes and protected newborns of immunized dams against the GBS challenge. The findings indicate that i.n. immunization targeting multiple conserved GBS virulence factors induces serotype-independent immunity, which protects against GBS infection systemically and vaginally in dams and prevents newborn deaths. View this paper
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Articles (117)

  • Review
  • Open Access
24 Citations
8,976 Views
14 Pages

Streptococcus pyogenes: Pathogenesis and the Current Status of Vaccines

  • Jiachao Wang,
  • Cuiqing Ma,
  • Miao Li,
  • Xue Gao,
  • Hao Wu,
  • Wenbin Dong and
  • Lin Wei

21 September 2023

Streptococcus pyogenes (group A Streptococcus; GAS), a Gram-positive coccal bacterium, poses a significant global disease burden, especially in low- and middle-income countries. Its manifestations can range from pharyngitis and skin infection to seve...

  • Article
  • Open Access
6 Citations
2,927 Views
16 Pages

Exploring the Effects of Vitamin D and Vitamin A Levels on the Response to COVID-19 Vaccine

  • Hassan M. Kofahi,
  • Baha’ R. Badran,
  • Refat M. Nimer,
  • Ali M. Atoom and
  • Shefa’ M. Al Hersh

21 September 2023

COVID-19 vaccines were developed at an unprecedented speed in history. The factors affecting the response to COVID-19 vaccines are not clear. Herein, the effects of vitamin D and vitamin A (retinol) levels on the response to the BNT162b2 vaccine were...

  • Article
  • Open Access
7 Citations
2,750 Views
12 Pages

Intention, Motivation, and Empowerment: Factors Associated with Seasonal Influenza Vaccination among Healthcare Workers (HCWs)

  • Thalia Bellali,
  • Polyxeni Liamopoulou,
  • Savvato Karavasileiadou,
  • Noura Almadani,
  • Petros Galanis,
  • George Kritsotakis and
  • Georgios Manomenidis

21 September 2023

Background: Vaccination against seasonal influenza has proven effective in preventing nosocomial influenza outbreaks among hospital patients and healthcare workers (HCWs). This study aims to explore the intention, motivation, and empowerment toward v...

  • Article
  • Open Access
2 Citations
2,665 Views
18 Pages

21 September 2023

Vaccine-preventable diseases (VPDs) remain a significant public health challenge, particularly in sub-Saharan Africa. The high burden of VPDs in this region necessitates the need for continued investigation and intervention. This paper presents a bib...

  • Review
  • Open Access
9 Citations
5,425 Views
14 Pages

An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines

  • Doddy Irawan Setyo Utomo,
  • Hamizah Suhaimi,
  • Nor Azila Muhammad Azami,
  • Fazren Azmi,
  • Mohd Cairul Iqbal Mohd Amin and
  • Jian Xu

20 September 2023

Recently, a great effort has been devoted to studying attenuated and subunit vaccine development against SARS-CoV-2 since its outbreak in December 2019. It is known that diverse virus-like particles (VLPs) are extensively employed as carriers to disp...

  • Article
  • Open Access
5 Citations
4,142 Views
10 Pages

A Lesson from a Measles Outbreak among Healthcare Workers in a Single Hospital in South Korea: The Importance of Knowing the Prevalence of Susceptibility

  • Sungim Choi,
  • Jae-Woo Chung,
  • Yun Jung Chang,
  • Eun Jung Lim,
  • Sun Hee Moon,
  • Han Ho Do,
  • Jeong Hun Lee,
  • Sung-Min Cho,
  • Bum Sun Kwon and
  • Yoon-Seok Chung
  • + 1 author

20 September 2023

Background: Despite the high vaccination coverage rate, in-hospital transmission of measles continues to occur in South Korea. We present a measles outbreak in which two healthcare workers (HCWs) with presumptive evidence of measles immunity were inf...

  • Article
  • Open Access
3 Citations
3,594 Views
18 Pages

Group A Streptococcus Vaccine Targeting the Erythrogenic Toxins SpeA and SpeB Is Safe and Immunogenic in Rabbits and Does Not Induce Antibodies Associated with Autoimmunity

  • Matthew J. Troese,
  • Elodie Burlet,
  • Madeleine W. Cunningham,
  • Kathy Alvarez,
  • Rebecca Bentley,
  • Nissy Thomas,
  • Shanna Carwell and
  • Garry L. Morefield

20 September 2023

Group A streptococcus (GAS) is a global pathogen associated with significant morbidity and mortality for which there is currently no licensed vaccine. Vaccine development has been slow, mostly due to safety concerns regarding streptococcal antigens a...

  • Article
  • Open Access
5 Citations
3,533 Views
14 Pages

ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine

  • Sehui Kim,
  • Yeji Park,
  • Jeonghun Kim,
  • Sohyun Kim,
  • Kyungmin Choi,
  • Taegyun Kang,
  • Inho Lee,
  • Yong Taik Lim,
  • Soong Ho Um and
  • Chul Kim

19 September 2023

Despite numerous studies on cancer treatment, cancer remains a challenging disease to cure, even after decades of research. In recent years, the cancer vaccine has emerged as a promising approach for cancer treatment, offering few unexpected side eff...

  • Review
  • Open Access
25 Citations
4,000 Views
26 Pages

Key Considerations during the Transition from the Acute Phase of the COVID-19 Pandemic: A Narrative Review

  • Piotr Rzymski,
  • Maria Pokorska-Śpiewak,
  • Teresa Jackowska,
  • Ernest Kuchar,
  • Aneta Nitsch-Osuch,
  • Małgorzata Pawłowska,
  • Mateusz Babicki,
  • Jerzy Jaroszewicz,
  • Leszek Szenborn and
  • Jacek Wysocki
  • + 1 author

19 September 2023

The COVID-19 pandemic has been met with an unprecedented response from the scientific community, leading to the development, investigation, and authorization of vaccines and antivirals, ultimately reducing the impact of SARS-CoV-2 on global public he...

  • Article
  • Open Access
2,068 Views
14 Pages

Replicate Testing of Clinical Endpoints Can Prevent No-Go Decisions for Beneficial Vaccines

  • Daniel I. S. Rosenbloom,
  • Julie Dudášová,
  • Casey Davis,
  • Radha A. Railkar,
  • Nitin Mehrotra and
  • Jeffrey R. Sachs

19 September 2023

In vaccine efficacy trials, inaccurate counting of infection cases leads to systematic under-estimation—or “dilution”—of vaccine efficacy. In particular, if a sufficient fraction of observed cases are false positives, apparent...

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Vaccines - ISSN 2076-393X