Table of Contents
Antioxidants, Volume 9, Issue 2 (February 2020) – 99 articles
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Cover Story (view full-size image) The study unveils for the first time that a cardinal entrant on the pathogenesis of pulmonary [...] Read more. The study unveils for the first time that a cardinal entrant on the pathogenesis of pulmonary arterial hypertension (PAH) is the nitration modification of Akt at Tyr-350 residue. We reported high levels of Akt nitration in idiopathic PAH and in the Sugen/hypoxia model. To delineate the involvement of Akt nitration in pathological signaling, a nitroxide conjugated affinity peptide was developed that specifically protects the Tyr-350 of Akt from nitration. This is the first report on using precise antioxidant delivery to a target protein. Treatment of the PAH model with nitroxide peptide blocked Akt nitration and resulted in the inhibition of metabolic reprogramming, vascular proliferation and remodeling, and normalization of right ventricular pressure in the Sugen/hypoxia model. View this paper.