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Antioxidants, Volume 9, Issue 2

2020 February - 99 articles

Cover Story: The study unveils for the first time that a cardinal entrant on the pathogenesis of pulmonary arterial hypertension (PAH) is the nitration modification of Akt at Tyr-350 residue. We reported high levels of Akt nitration in idiopathic PAH and in the Sugen/hypoxia model. To delineate the involvement of Akt nitration in pathological signaling, a nitroxide conjugated affinity peptide was developed that specifically protects the Tyr-350 of Akt from nitration. This is the first report on using precise antioxidant delivery to a target protein. Treatment of the PAH model with nitroxide peptide blocked Akt nitration and resulted in the inhibition of metabolic reprogramming, vascular proliferation and remodeling, and normalization of right ventricular pressure in the Sugen/hypoxia model. View this paper.
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Articles (99)

  • Article
  • Open Access
48 Citations
7,645 Views
22 Pages

Influence of a Selenium Biofortification on Antioxidant Properties and Phenolic Compounds of Apples (Malus domestica)

  • Sabrina Groth,
  • Christoph Budke,
  • Susanne Neugart,
  • Sofia Ackermann,
  • Fenja-Sarah Kappenstein,
  • Diemo Daum and
  • Sascha Rohn

24 February 2020

Biofortified apples seem to be a suitable produce. In this study, different selenium forms and application levels were applied to the two apple varieties ‘Golden Delicious’ and ‘Jonagold’, grown in the years 2017 and 2018 in o...

  • Article
  • Open Access
94 Citations
10,021 Views
18 Pages

Nutrients, Antinutrients, Phenolic Composition, and Antioxidant Activity of Common Bean Cultivars and their Potential for Food Applications

  • Bruna Carbas,
  • Nelson Machado,
  • David Oppolzer,
  • Luís Ferreira,
  • Marcelo Queiroz,
  • Carla Brites,
  • Eduardo AS Rosa and
  • Ana IRNA Barros

23 February 2020

Phaseolus vulgaris L. is the most commonly consumed legume in the world, given its high vegetable protein content, phenolic compounds, and antioxidant properties. It also represents one of the most sustainable, low-carbon and sources of food availabl...

  • Review
  • Open Access
162 Citations
45,485 Views
17 Pages

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

  • Gabriel Aguirre-Cruz,
  • Arely León-López,
  • Verónica Cruz-Gómez,
  • Rubén Jiménez-Alvarado and
  • Gabriel Aguirre-Álvarez

22 February 2020

Antioxidants are molecules that delay or inhibit the oxidation of other molecules. Its use significantly increased in recent years in the diet of people. Natural antioxidants are replacing the use of synthetic antioxidant ingredients due to their saf...

  • Article
  • Open Access
29 Citations
6,407 Views
24 Pages

The Oxidative Stress Markers in the Erythrocytes and Heart Muscle of Obese Rats: Relate to a High-Fat Diet but Not to DJOS Bariatric Surgery

  • Bronisława Skrzep-Poloczek,
  • Jakub Poloczek,
  • Elżbieta Chełmecka,
  • Agnieszka Dulska,
  • Ewa Romuk,
  • Maciej Idzik,
  • Wojciech Kazura,
  • Katarzyna Nabrdalik,
  • Janusz Gumprecht and
  • Dominika Marta Stygar
  • + 1 author

22 February 2020

Obesity and high-fat diet (HF) are prevalent causes of oxidative stress (OS). Duodenal-jejunal omega switch (DJOS) is a bariatric procedure used for body mass reduction, extensively tested in animal models. We studied the long-term impact of bariatri...

  • Article
  • Open Access
74 Citations
7,367 Views
25 Pages

Contribution of Flavonoids and Iridoids to the Hypoglycaemic, Antioxidant, and Nitric Oxide (NO) Inhibitory Activities of Arbutus unedo L.

  • Maria Concetta Tenuta,
  • Brigitte Deguin,
  • Monica Rosa Loizzo,
  • Annabelle Dugay,
  • Rosaria Acquaviva,
  • Giuseppe Antonio Malfa,
  • Marco Bonesi,
  • Chouaha Bouzidi and
  • Rosa Tundis

22 February 2020

This study aims at investigating the contribution of two classes of compounds, flavonoids and iridoids, to the bioactivity of Arbutus unedo L. leaves and fruits. The impact of different extraction procedures on phytochemicals content and hypoglycemic...

  • Article
  • Open Access
12 Citations
5,893 Views
19 Pages

Beneficial Impact of an Extract from the Berries of Aronia melanocarpa L. on the Oxidative-Reductive Status of the Submandibular Gland of Rats Exposed to Cadmium

  • Adam Dąbrowski,
  • Barbara M. Onopiuk,
  • Halina Car,
  • Paweł Onopiuk,
  • Zofia N. Dąbrowska,
  • Joanna Rogalska,
  • Małgorzata M. Brzóska and
  • Ewa Dąbrowska

22 February 2020

Oxidative stress underlies the pathomechanisms of toxic action of cadmium (Cd), including its damaging impact on the oral cavity. This study investigated whether the administration of an extract from Aronia melanocarpa L. berries (AME), characterized...

  • Review
  • Open Access
54 Citations
31,527 Views
17 Pages

Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

  • Lourdes Alvarez-Arellano,
  • Nadia González-García,
  • Marcela Salazar-García and
  • Juan Carlos Corona

21 February 2020

Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects....

  • Article
  • Open Access
79 Citations
8,360 Views
16 Pages

The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent

  • Guillermo Cásedas,
  • Francisco Les,
  • Carmen Choya-Foces,
  • Martín Hugo and
  • Víctor López

21 February 2020

Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries. The objective of this study was to determine the cytoprotective capacity of this...

  • Article
  • Open Access
42 Citations
5,452 Views
14 Pages

Comparative Insight upon Chitosan Solution and Chitosan Nanoparticles Application on the Phenolic Content, Antioxidant and Antimicrobial Activities of Individual Grape Components of Sousão Variety

  • Vanessa Silva,
  • Rupesh Kumar Singh,
  • Nelson Gomes,
  • Bruno Gonçalves Soares,
  • Adriana Silva,
  • Virgílio Falco,
  • Rosa Capita,
  • Carlos Alonso-Calleja,
  • José Eduardo Pereira and
  • Patrícia Poeta
  • + 2 authors

21 February 2020

Chitosan, a natural polysaccharide, has been previously proposed as an elicitor in plants to prevent pathogen infections. The present study aimed to analyze the effect of chitosan solution and chitosan nanoparticles treatment applied on the grapevine...

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Antioxidants - ISSN 2076-3921