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Antioxidants, Volume 9, Issue 3

March 2020 - 81 articles

Cover Story: Ageing increases the risks of arterial stiffness mainly through the effects of oxidative stress. These effects of ageing and oxidative stress on arterial stiffness can be moderated by exercise training. Fibroblast growth factor 21 (FGF21) and adiponectin increase expression of genes involved in antioxidant pathways and decrease oxidative stress. In healthy non-obese active and sedentary individuals, distributed equally in younger and older age groups, ageing was positively associated with oxidative stress and arterial stiffness. However, these relationships were independent of exercise training and the FGF21–adiponectin axis. Contrary to the findings from previous studies, these results suggest that habitual exercise may not be effective in attenuating oxidative stress and arterial stiffness in healthy non-obese individuals. View this paper.
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Articles (81)

  • Article
  • Open Access
71 Citations
6,750 Views
19 Pages

Green-Sustainable Recovery of Phenolic and Antioxidant Compounds from Industrial Chestnut Shells Using Ultrasound-Assisted Extraction: Optimization and Evaluation of Biological Activities In Vitro

  • Fátima Lameirão,
  • Diana Pinto,
  • Elsa F. Vieira,
  • Andreia F. Peixoto,
  • Cristina Freire,
  • Stefania Sut,
  • Stefano Dall’Acqua,
  • Paulo Costa,
  • Cristina Delerue-Matos and
  • Francisca Rodrigues

Chestnut processing industry generates large amounts of by-products, including leaves, burs and shells that are a source of bioactive compounds. The purpose of this study was to establish an ultrasound-assisted extraction (UAE) of phenolic and antiox...

  • Article
  • Open Access
14 Citations
4,380 Views
16 Pages

In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea Accessions: Differential Effects on Hepatic Lipid Over-Accumulation

  • Mariangela Centrone,
  • Patrizia Gena,
  • Marianna Ranieri,
  • Annarita Di Mise,
  • Mariagrazia D’Agostino,
  • Maria Mastrodonato,
  • Maria Venneri,
  • Davide De Angelis,
  • Stefano Pavan and
  • Antonella Pasqualone
  • + 5 authors

Dietary habits are crucially important to prevent the development of lifestyle-associated diseases. Diets supplemented with chickpeas have numerous benefits and are known to improve body fat composition. The present study was undertaken to characteri...

  • Article
  • Open Access
46 Citations
5,346 Views
21 Pages

Astaxanthin Prevents Mitochondrial Impairment Induced by Isoproterenol in Isolated Rat Heart Mitochondria

  • Olga Krestinina,
  • Yulia Baburina,
  • Roman Krestinin,
  • Irina Odinokova,
  • Irina Fadeeva and
  • Linda Sotnikova

Mitochondria are considered to be a power station of the cell. It is known that they play a major role in both normal and pathological heart function. Alterations in mitochondrial bioenergetics are one of the main causes of the origin and progression...

  • Article
  • Open Access
25 Citations
6,147 Views
16 Pages

Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction

  • Vivian Doerr,
  • Ryan N. Montalvo,
  • Oh Sung Kwon,
  • Erin E. Talbert,
  • Brian A. Hain,
  • Fraser E. Houston and
  • Ashley J. Smuder

Clinical use of the chemotherapeutic doxorubicin (DOX) promotes skeletal muscle atrophy and weakness, adversely affecting patient mobility and strength. Although the mechanisms responsible for DOX-induced skeletal muscle dysfunction remain unclear, s...

  • Review
  • Open Access
142 Citations
15,279 Views
31 Pages

Carotenoid pigments, particularly β-carotene and lycopene, are consumed in human foodstuffs and play a vital role in maintaining health. β-carotene is known to quench singlet oxygen and can have strong antioxidant activity. As such, it was...

  • Article
  • Open Access
79 Citations
6,781 Views
18 Pages

Water Ultrasound-Assisted Extraction of Polyphenol Compounds from Brewer’s Spent Grain: Kinetic Study, Extract Characterization, and Concentration

  • Patricia Alonso-Riaño,
  • María Teresa Sanz Diez,
  • Beatriz Blanco,
  • Sagrario Beltrán,
  • Ester Trigueros and
  • Oscar Benito-Román

Brewer’s spent grain (BSG) was chemically characterized obtaining 52.1% of carbohydrates, 17.8% protein, 5.9% lipids, 13.5% insoluble lignin and 24.3% of water-soluble extractives. This work has been focused on the study of polyphenol extractio...

  • Article
  • Open Access
34 Citations
5,212 Views
18 Pages

Effects of Melatonin Administration to Pregnant Ewes under Heat-Stress Conditions, in Redox Status and Reproductive Outcome

  • Efterpi Bouroutzika,
  • Dimitrios Kouretas,
  • Serafeim Papadopoulos,
  • Aristidis S. Veskoukis,
  • Ekaterini Theodosiadou,
  • Sotiria Makri,
  • Charilaos Paliouras,
  • Marios-Lazaros Michailidis,
  • Mariangela Caroprese and
  • Irene Valasi

Heat stress is a known promoter of reactive oxygen species generation, which may compromise pregnancy and foetal development. Melatonin is a pleiotropic molecule that regulates various processes including pregnancy. Thus, it could be used to ameliora...

  • Review
  • Open Access
92 Citations
10,299 Views
34 Pages

Antioxidant Therapies in Traumatic Brain Injury

  • Valentina Di Pietro,
  • Kamal M. Yakoub,
  • Giuseppe Caruso,
  • Giacomo Lazzarino,
  • Stefano Signoretti,
  • Aron K. Barbey,
  • Barbara Tavazzi,
  • Giuseppe Lazzarino,
  • Antonio Belli and
  • Angela Maria Amorini

Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly heterogeneous pathology, characterized by high mortality and disability rates. TBI is an acute neurodegenerative event, potentially and unpredictably evolving int...

  • Article
  • Open Access
16 Citations
4,681 Views
19 Pages

Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity

  • Seu-Hwa Chen,
  • Kuo-Ching Yuan,
  • Yu-Chieh Lee,
  • Chun-Kuang Shih,
  • Sung-Hui Tseng,
  • Alexey A. Tinkov,
  • Anatoly V. Skalny and
  • Jung-Su Chang

The literature suggests a bidirectional relationship between testosterone (T) and iron, but mechanisms underlying this relationship remain unclear. We investigated effects of iron on advanced glycation end products (AGEs) in obesity-related androgen...

  • Article
  • Open Access
7 Citations
3,804 Views
19 Pages

Eucalyptus is a worldwide hard-wood species which increasingly focused on. To adapt to various biotic and abiotic stresses, Eucalyptus have evolved complex mechanisms, increasing the cellular concentration of reactive oxygen species (ROS) by numerous...

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Antioxidants - ISSN 2076-3921