Special Issue "Modulators of Oxidative Stress: Chemical and Pharmacological Aspects"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 January 2020.

Special Issue Editors

Prof. Dr. Luciano Saso
E-Mail Website
Guest Editor
Prof. Hande Gurer-Orhan
E-Mail Website
Co-Guest Editor
Toxicology Department, Faculty of Pharmacy, Ege University, 35040 Izmir, Turkey
Interests: endocrine and/or oxidative stress-modulating compounds, mainly melatonin analogues, as therapeutic agents in hormone-related diseases
Dr. Višnja Stepanić
E-Mail Website
Co-Guest Editor
Rudjer Bosković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
Interests: chemo/bioinformatics; modulation of oxidative stress; chemoprevention

Special Issue Information

Dear Collegaues,

Reactive oxygen (ROS), nitrogen (RNS), and sulfur (RSS) species are implicated in the pathogenesis of a variety of pathological conditions, including chronic infections, inflammatory disorders, cardiovascular diseases, neurodegenerative diseases, and cancer. Unfortunately, antioxidant therapies did not prove to be effective in most of the clinical studies for different reasons that have been reviewed elsewhere [1,2]. However, modulation of oxidative stress, particularly through regulation of gene transcription through, e.g., activation or inhibition of Nrf2, is considered to be an important strategy for the development of new drugs for some of these pathologies, such as cardiovascular and neoplastic diseases that are resistant to other treatments [3–5]. The main aim of this Special Issue is to present studies that address different chemical, biological, physiological, pharmaceutical, and pharmacological aspects of the modulation of oxidative stress. Potential topics include, but are not limited to:

  • synthesis and derivatization of oxidative stress modulators with potential pharmacological applications, and the optimization of their antioxidant properties and bioavailability;
  • non-radical scavenging mechanisms of action of oxidative stress modulators, particularly the Keap1/Nrf2/ARE signaling pathway;
  • pharmacokinetics, metabolic pathways, and antioxidant activity of metabolites
  • in vitro and in vivo studies on the pharmacological activity of oxidative stress modulators;
  • epidemiological and clinical studies on the efficacy of redox therapies; and
  • relevant biological markers for assessing in vivo antioxidant/pro-oxidant activity and its correlation with clinical efficacy.
Prof. Dr. Luciano Saso
Prof. Hande Gurer-Orhan
Dr. Višnja Stepanić
Guest Editors

Selected references

  1. Firuzi, O.; Miri, R.; Tavakkoli, M.; Saso, L. Antioxidant therapy: current status and future prospects. Med. Chem. 2011, 18, 3871–3888.
  2. Saso, L.; Firuzi, O. Pharmacological applications of antioxidants: lights and shadows. Drug Targets 2014, 15, 1177–1199.
  3. Panieri, E.; Saso, L. Potential Applications of NRF2 Inhibitors in Cancer Therapy. Med. Cell. Longev. 2019, 2019, 8592348.
  4. Telkoparan-Akillilar, P.; Suzen, S.; Saso, L. Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs. J. Mol. Sci. 2019, 20, 2025.
  5. Sova, M.; Saso, L. Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review. Drug Des. Devel Ther. 2018, 12, 3181–3197.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • modulation of oxidative stress
  • gene transcription modulation
  • Nrf2

Published Papers (2 papers)

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Research

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Open AccessArticle
The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion
Antioxidants 2019, 8(12), 614; https://doi.org/10.3390/antiox8120614 - 03 Dec 2019
Abstract
Acute myocardial infarction is one of the leading causes of death worldwide and thus, an extensively studied disease. Nonetheless, the effects of ischemia/reperfusion injury elicited by oxidative stress on cardiac fibroblast function associated with tissue repair are not completely understood. Ascorbic acid, deferoxamine, [...] Read more.
Acute myocardial infarction is one of the leading causes of death worldwide and thus, an extensively studied disease. Nonetheless, the effects of ischemia/reperfusion injury elicited by oxidative stress on cardiac fibroblast function associated with tissue repair are not completely understood. Ascorbic acid, deferoxamine, and N-acetylcysteine (A/D/N) are antioxidants with known cardioprotective effects, but the potential beneficial effects of combining these antioxidants in the tissue repair properties of cardiac fibroblasts remain unknown. Thus, the aim of this study was to evaluate whether the pharmacological association of these antioxidants, at low concentrations, could confer protection to cardiac fibroblasts against simulated ischemia/reperfusion injury. To test this, neonatal rat cardiac fibroblasts were subjected to simulated ischemia/reperfusion in the presence or absence of A/D/N treatment added at the beginning of simulated reperfusion. Cell viability was assessed using trypan blue staining, and intracellular reactive oxygen species (ROS) production was assessed using a 2′,7′-dichlorofluorescin diacetate probe. Cell death was measured by flow cytometry using propidium iodide. Cell signaling mechanisms, differentiation into myofibroblasts and pro-collagen I production were determined by Western blot, whereas migration was evaluated using the wound healing assay. Our results show that A/D/N association using a low concentration of each antioxidant increased cardiac fibroblast viability, but that their separate administration did not provide protection. In addition, A/D/N association attenuated oxidative stress triggered by simulated ischemia/reperfusion, induced phosphorylation of pro-survival extracellular-signal-regulated kinases 1/2 (ERK1/2) and PKB (protein kinase B)/Akt, and decreased phosphorylation of the pro-apoptotic proteins p38- mitogen-activated protein kinase (p38-MAPK) and c-Jun-N-terminal kinase (JNK). Moreover, treatment with A/D/N also reduced reperfusion-induced apoptosis, evidenced by a decrease in the sub-G1 population, lower fragmentation of pro-caspases 9 and 3, as well as increased B-cell lymphomaextra large protein (Bcl-xL)/Bcl-2-associated X protein (Bax) ratio. Furthermore, simulated ischemia/reperfusion abolished serum-induced migration, TGF-β1 (transforming growth factor beta 1)-mediated cardiac fibroblast-to-cardiac myofibroblast differentiation, and angiotensin II-induced pro-collagen I synthesis, but these effects were prevented by treatment with A/D/N. In conclusion, this is the first study where a pharmacological combination of A/D/N, at low concentrations, protected cardiac fibroblast viability and function after simulated ischemia/reperfusion, and thereby represents a novel therapeutic approach for cardioprotection. Full article
(This article belongs to the Special Issue Modulators of Oxidative Stress: Chemical and Pharmacological Aspects)
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Open AccessReview
The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression
Antioxidants 2019, 8(12), 640; https://doi.org/10.3390/antiox8120640 - 12 Dec 2019
Abstract
Reactive oxygen species (ROS) are important secondary metabolites that play major roles in signaling pathways, with their levels often used as analytical tools to investigate various cellular scenarios. They potentially damage genetic material and facilitate tumorigenesis by inhibiting certain tumor suppressors. In diabetic [...] Read more.
Reactive oxygen species (ROS) are important secondary metabolites that play major roles in signaling pathways, with their levels often used as analytical tools to investigate various cellular scenarios. They potentially damage genetic material and facilitate tumorigenesis by inhibiting certain tumor suppressors. In diabetic conditions, substantial levels of ROS stimulate oxidative stress through specialized precursors and enzymatic activity, while minimum levels are required for proper wound healing. Photobiomodulation (PBM) uses light to stimulate cellular mechanisms and facilitate the removal of oxidative stress. Photodynamic therapy (PDT) generates ROS to induce selective tumor destruction. The regulatory roles of PBM via crosstalk between ROS and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) are substantial for the appropriate management of various conditions. Full article
(This article belongs to the Special Issue Modulators of Oxidative Stress: Chemical and Pharmacological Aspects)
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