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Open AccessArticle

Development of a Phytomelatonin-Rich Extract from Cultured Plants with Excellent Biochemical and Functional Properties as an Alternative to Synthetic Melatonin

1
Department of Physiology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
2
Department of Plant Biology, (Plant Physiology), Faculty of Biology, University of Murcia, 30100 Murcia, Spain
3
Department of Cell Biology & Histology, Faculty of Biology, University of Murcia, 30100 Murcia, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(2), 158; https://doi.org/10.3390/antiox9020158
Received: 23 January 2020 / Revised: 11 February 2020 / Accepted: 12 February 2020 / Published: 16 February 2020
Melatonin is a pleiotropic molecule with multiple and various functions. In recent years, there has been a considerable increase in the consumption of melatonin supplements for reasons other than those related with sleep (as an antioxidant, for anti-aging, and as a hunger regulator). Although the chemical synthesis of melatonin has recently been improved, several unwanted by-products of the chemical reactions involved occur as contaminants. Phytomelatonin, melatonin of plant origin, was discovered in several plants in 1995, and the possibility of using raw plant material as a source to obtain dietary supplements rich in phytomelatonin instead of synthetic melatonin, with its corresponding chemical by-products was raised. This work characterizes the phytomelatonin-rich extract obtained from selected plant material and determines the contents in phytomelatonin, phenols, flavonoids, and carotenoids. Additionally, the antioxidant activity was measured. Finally, a melatonin-specific bioassay in fish was carried out to demonstrate the excellent biological properties of the natural phytomelatonin-rich extract obtained. View Full-Text
Keywords: food supplement; jet-lag; melatonin; nutraceutical; phytomelatonin; sleep disorders food supplement; jet-lag; melatonin; nutraceutical; phytomelatonin; sleep disorders
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MDPI and ACS Style

Pérez-Llamas, F.; Hernández-Ruiz, J.; Cuesta, A.; Zamora, S.; Arnao, M.B. Development of a Phytomelatonin-Rich Extract from Cultured Plants with Excellent Biochemical and Functional Properties as an Alternative to Synthetic Melatonin. Antioxidants 2020, 9, 158. https://doi.org/10.3390/antiox9020158

AMA Style

Pérez-Llamas F, Hernández-Ruiz J, Cuesta A, Zamora S, Arnao MB. Development of a Phytomelatonin-Rich Extract from Cultured Plants with Excellent Biochemical and Functional Properties as an Alternative to Synthetic Melatonin. Antioxidants. 2020; 9(2):158. https://doi.org/10.3390/antiox9020158

Chicago/Turabian Style

Pérez-Llamas, Francisca; Hernández-Ruiz, Josefa; Cuesta, Alberto; Zamora, Salvador; Arnao, Marino B. 2020. "Development of a Phytomelatonin-Rich Extract from Cultured Plants with Excellent Biochemical and Functional Properties as an Alternative to Synthetic Melatonin" Antioxidants 9, no. 2: 158. https://doi.org/10.3390/antiox9020158

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