Table of Contents
Brain Sci., Volume 9, Issue 3 (March 2019) – 26 articles
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Cover Story (view full-size image) Alcohol use disorder (AUD) is a chronic relapsing brain disease with a lifetime prevalence of ~29%. [...] Read more. Alcohol use disorder (AUD) is a chronic relapsing brain disease with a lifetime prevalence of ~29%. AUD has devastating consequences for the affected individual and their families. In addition, the financial burden to society is enormous. While previous work has found that AUD has a high rate of heritability, DNA variants identified by genetic studies only explain a small amount of this heritability. Beeler et al. tested the hypothesis that alcohol-induced epigenetic changes contribute to the effects of alcohol across generations. Using an inbred mouse model, Beeler et al. demonstrated that paternal preconception voluntary alcohol drinking altered various behaviors and alcohol consumption in adult offspring. This study adds to a growing literature that one’s alcohol drinking behavior is impacted by ancestral alcohol exposure. Images used under license from Shutterstock.com. View this paper