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Parkinsonism Risk Factors in Salt Lake City, Utah: A Community-Based Study

1
Banner Sun Health Research Institute, 10515 W. Santa Fe Drive, Sun City, AZ 85351, USA
2
Department of Neurology, University of Utah, 175 North Medical Drive East, Salt Lake City, UT 84132, USA
3
Department of Neurology, University of Arizona, Phoenix, AZ 85724, USA
4
Department of Biostatistics, Mayo Clinic, Scottsdale, AZ 85259, USA
5
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
6
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(3), 71; https://doi.org/10.3390/brainsci9030071
Received: 18 February 2019 / Revised: 18 March 2019 / Accepted: 20 March 2019 / Published: 23 March 2019
(This article belongs to the Collection Collection on Clinical Neuroscience)
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PDF [204 KB, uploaded 23 March 2019]
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Abstract

Background: The prevalence of dream enactment behavior and other risk factors for a parkinsonian disorder is not well documented. Methods: A survey on prevalence of parkinsonism risk factors was designed using two validated instruments (REM behavior disorder single item question, bowel movement frequency for constipation) and three exploratory instruments (for hallucinations, cognitive and olfactory complaints.) It was sent by mail and email to patients aged 50 and over at two University of Utah community clinics in Salt Lake City. A total of 7888 unique patients were sent the survey, and 1607 responses were recorded (response rate 20%). Those whose age was missing (n = 117) or less than 50 years (n = 10) were excluded from the analysis. Results: Of the 1406 without personal diagnosis of neurodegenerative disease 62.7% were female, and median age was 63. Family history (FH) of Parkinson’s disease was endorsed by 9%, constipation (defined as a bowel movement less than once per day) by 19%, mild cognitive complaints (MCI) 15.8%, dream enactment 13.7%, subjective hyposmia or anosmia 18.2%, and at least one potential psychotic symptom in 37.6%. Multivariable logistic regression showed male gender, mild cognitive complaints, hearing voices, and at least one potentially psychotic symptom to be significantly associated with dream enactment. Conclusions: This survey shows that dream enactment, a strong predictor of risk for synucleinopathy, is relatively common in the older population; because such individuals rarely come to medical attention of a sleep clinic, such survey research may be useful to identify and recruit at-risk individuals for trials aimed at preventing neurodegenerative disease. View Full-Text
Keywords: parkinsonism; Parkinson’s disease; anosmia; hyposmia; psychosis; dementia with Lewy bodies; REM sleep behavior disorder; constipation; mild cognitive impairment parkinsonism; Parkinson’s disease; anosmia; hyposmia; psychosis; dementia with Lewy bodies; REM sleep behavior disorder; constipation; mild cognitive impairment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Shprecher, D.; Zhang, N.; Halverson, M.; Savica, R. Parkinsonism Risk Factors in Salt Lake City, Utah: A Community-Based Study. Brain Sci. 2019, 9, 71.

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