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Pathogens, Volume 10, Issue 5

May 2021 - 133 articles

Cover Story: The circadian clock modulates many physiological processes, including hormone secretion, immune responses, and sleep–wake cycles. Given the impact of diurnal variations on numerous blood-borne factors and the increasing interest in EVs and their miRNAs content as biomarkers for the pathological state, we describe daily variations of two types of plasma EVs, abundance and microRNA contents for HIV-negative people and PLWH. Variation between day and night of large EV abundance and their microRNA contents is least in PLWH despite the suppression of viral replication under ART. An improved understanding of EV production and their miRNA content, as well as their circadian variation, may inform us on pathogenesis. Moreover, measurement of EV daily variation could dictate the best timing of therapeutic interventions and determination of clinical efficacy. View this paper
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Articles (133)

  • Communication
  • Open Access
3 Citations
2,900 Views
8 Pages

IL-16 and BCA-1 Serum Levels Are Associated with Disease Severity of C. difficile Infection

  • Dor Gotshal,
  • Maya Azrad,
  • Zohar Hamo,
  • Orna Nitzan and
  • Avi Peretz

Clostridioides difficile infection (CDI) is associated with a high risk for complications and death, which requires identifying severe patients and treating them accordingly. We examined the serum level of six cytokines and chemokines (IL-16, IL-21,...

  • Review
  • Open Access
153 Citations
22,418 Views
23 Pages

Avian Influenza in Wild Birds and Poultry: Dissemination Pathways, Monitoring Methods, and Virus Ecology

  • Artem Blagodatski,
  • Kseniya Trutneva,
  • Olga Glazova,
  • Olga Mityaeva,
  • Liudmila Shevkova,
  • Evgenii Kegeles,
  • Nikita Onyanov,
  • Kseniia Fede,
  • Anna Maznina and
  • Elena Khavina
  • + 3 authors

Avian influenza is one of the largest known threats to domestic poultry. Influenza outbreaks on poultry farms typically lead to the complete slaughter of the entire domestic bird population, causing severe economic losses worldwide. Moreover, there a...

  • Article
  • Open Access
51 Citations
5,514 Views
22 Pages

Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate

  • Raya Soltane,
  • Amani Chrouda,
  • Ahmed Mostafa,
  • Ahmed A. Al-Karmalawy,
  • Karim Chouaïb,
  • Abdelwaheb dhahri,
  • Rami Adel Pashameah,
  • Ahlam Alasiri,
  • Omnia Kutkat and
  • Mahmoud Shehata
  • + 3 authors

In late December 2019, a novel coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), escaped the animal–human interface and emerged as an ongoing global pandemic with severe flu-like illness, commonly known as coronavirus...

  • Article
  • Open Access
14 Citations
4,293 Views
19 Pages

Molecular Characterization of 4/91 Infectious Bronchitis Virus Leading to Studies of Pathogenesis and Host Responses in Laying Hens

  • Shahnas M. Najimudeen,
  • Mohamed S. H. Hassan,
  • Dayna Goldsmith,
  • Davor Ojkic,
  • Susan C. Cork,
  • Martine Boulianne and
  • Mohamed Faizal Abdul-Careem

Infectious bronchitis virus (IBV) initially establishes the infection in the respiratory tract and then spreads to other tissues depending on its virulence. During 2011–2018, the 4/91 IBV strain was isolated from poultry flocks affected by decreased...

  • Article
  • Open Access
3 Citations
3,639 Views
12 Pages

Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation

  • Sarah-Kim Friedrich,
  • Rosa Schmitz,
  • Michael Bergerhausen,
  • Judith Lang,
  • Vikas Duhan,
  • Cornelia Hardt,
  • Matthias Tenbusch,
  • Marco Prinz,
  • Kenichi Asano and
  • Hilal Bhat
  • + 3 authors

The replication of viruses in secondary lymphoid organs guarantees sufficient amounts of pattern-recognition receptor ligands and antigens to activate the innate and adaptive immune system. Viruses with broad cell tropism usually replicate in lymphoi...

  • Article
  • Open Access
2 Citations
3,428 Views
8 Pages

Response of Severe EV71-Infected Patients to Hyperimmune Plasma Treatment: A Pilot Study

  • Chonnamet Techasaensiri,
  • Artit Wongsa,
  • Thanyawee Puthanakit,
  • Kulkanya Chokephaibulkit,
  • Tawee Chotpitayasunondh,
  • Ubonwon Charoonruangrit,
  • Somjai Sombatnimitsakul,
  • Pilaipan Puthavathana,
  • Hatairat Lerdsamran and
  • Prasert Auewarakul
  • + 1 author

Hand, foot, and mouth disease (HFMD) is highly prevalent in East and Southeast Asia. It particularly affects children under five years of age. The most common causative agents are coxsackieviruses A6 and A16, and enterovirus A71 (EV71). The clinical...

  • Article
  • Open Access
10 Citations
6,255 Views
16 Pages

Immunogenicity of Adjuvanted Psoralen-Inactivated SARS-CoV-2 Vaccines and SARS-CoV-2 Spike Protein DNA Vaccines in BALB/c Mice

  • Appavu K. Sundaram,
  • Daniel Ewing,
  • Zhaodong Liang,
  • Vihasi Jani,
  • Ying Cheng,
  • Peifang Sun,
  • Kanakatte Raviprakash,
  • Shuenn-Jue Wu,
  • Nikolai Petrovsky and
  • Gabriel Defang
  • + 2 authors

The development of a safe and effective vaccine to protect against COVID-19 is a global priority due to the current high SARS-CoV-2 infection rate. Currently, there are over 160 SARS-CoV-2 vaccine candidates at the clinical or pre-clinical stages of...

  • Review
  • Open Access
14 Citations
4,743 Views
12 Pages

The infection of pregnant animals and women by Coxiella burnetii, an intracellular bacterium, compromises both maternal health and foetal development. The placenta is targeted by C. burnetii, as demonstrated by bacteriological and histological eviden...

  • Review
  • Open Access
4 Citations
3,681 Views
12 Pages

Airborne Coronaviruses: Observations from Veterinary Experience

  • Paolo Pozzi,
  • Alessio Soggiu,
  • Luigi Bonizzi,
  • Nati Elkin and
  • Alfonso Zecconi

The virus responsible for the pandemic that has affected 152 countries worldwide is a new strain of coronavirus (CoV), which belongs to a family of viruses widespread in many animal species, including birds, and mammals including humans. Indeed, CoVs...

  • Article
  • Open Access
3 Citations
3,151 Views
10 Pages

Molecular Detection of Bartonella quintana among Long-Tailed Macaques (Macaca fascicularis) in Thailand

  • Wanat Sricharern,
  • Supakarn Kaewchot,
  • Phirabhat Saengsawang,
  • Sarawan Kaewmongkol and
  • Tawin Inpankaew

Bartonella quintana is a zoonotic pathogen with a worldwide distribution. Humans and non-human primates are considered to be natural reservoir hosts for B. quintana. However, information on the molecular epidemiology of this organism is very limited...

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Pathogens - ISSN 2076-0817