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Article

A Nosocomial Outbreak of Invasive Listeriosis in An Italian Hospital: Epidemiological and Genomic Features

1
Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”—Sezione di Roma, 00178 Rome, Italy
2
Regional Service Surveillance and Control for Infectious Diseases (SERESMI), National Institute for Infectious Diseases “Lazzaro Spallanzani” IRCCS, 00149 Rome, Italy
3
Istituto Zooprofilattico Sperimentale del Lazio e della Toscana “M. Aleandri”—Sezione di Latina, 04100 Latina, Italy
4
Department of Prevention, Azienda Sanitaria Locale Latina, 04100 Latina, Italy
5
Ospedale Santa Maria Goretti, 04100 Latina, Italy
*
Author to whom correspondence should be addressed.
Authors equally contributed to this article.
Academic Editor: Janet R. Donaldson
Pathogens 2021, 10(5), 591; https://doi.org/10.3390/pathogens10050591
Received: 10 March 2021 / Revised: 29 April 2021 / Accepted: 10 May 2021 / Published: 12 May 2021
(This article belongs to the Special Issue Listeria monocytogenes Pathogenesis)
Listeria monocytogenes (L. monocytogenes) is a widespread opportunistic pathogen that causes the listeriosis foodborne disease. This bacterium has become a common contaminant of handled food, and a relevant public health issue. Here we describe a nosocomial outbreak of listeriosis caused by an ST451 strain of L. monocytogenes involving three cancer and one immunocompromised patients hospitalized in different units from the same hospital during September and October 2020. The epidemiological investigation was conducted using traditional microbiological methodology combined with a whole genome sequencing approach. The source of contamination was identified in the kitchen hospital, where a meat slicer used to prepare patients’ meals was tested positive to the same sequence type (ST) of L. monocytogenes. This is the first report of an outbreak of listeriosis caused by ST451 in Italy. View Full-Text
Keywords: listeriosis; whole genome sequencing; nosocomial outbreak; Listeria monocytogenes; ST451 listeriosis; whole genome sequencing; nosocomial outbreak; Listeria monocytogenes; ST451
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MDPI and ACS Style

Russini, V.; Spaziante, M.; Zottola, T.; Fermani, A.G.; Di Giampietro, G.; Blanco, G.; Fabietti, P.; Marrone, R.; Parisella, R.; Parrocchia, S.; Bossù, T.; Bilei, S.; De Marchis, M.L. A Nosocomial Outbreak of Invasive Listeriosis in An Italian Hospital: Epidemiological and Genomic Features. Pathogens 2021, 10, 591. https://doi.org/10.3390/pathogens10050591

AMA Style

Russini V, Spaziante M, Zottola T, Fermani AG, Di Giampietro G, Blanco G, Fabietti P, Marrone R, Parisella R, Parrocchia S, Bossù T, Bilei S, De Marchis ML. A Nosocomial Outbreak of Invasive Listeriosis in An Italian Hospital: Epidemiological and Genomic Features. Pathogens. 2021; 10(5):591. https://doi.org/10.3390/pathogens10050591

Chicago/Turabian Style

Russini, Valeria, Martina Spaziante, Tiziana Zottola, Anna G. Fermani, Gina Di Giampietro, Giovanni Blanco, Paolo Fabietti, Riccardo Marrone, Roberta Parisella, Sergio Parrocchia, Teresa Bossù, Stefano Bilei, and Maria L. De Marchis. 2021. "A Nosocomial Outbreak of Invasive Listeriosis in An Italian Hospital: Epidemiological and Genomic Features" Pathogens 10, no. 5: 591. https://doi.org/10.3390/pathogens10050591

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