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Diagnostics, Volume 15, Issue 18

September-2 2025 - 131 articles

Cover Story: Hepatic steatosis, or fatty liver, is a prevalent condition and an important precursor to cirrhosis and liver failure. Clinical diagnosis currently relies on invasive liver biopsy, as traditional computed tomography (CT) and simple attenuation thresholds lack the accuracy required to grade disease severity. Radiomics extracts high-dimensional quantitative features from medical images using mathematical formulas and enables fully automated characterization of subtle tissue patterns beyond human perception. In this study, we investigated whether CT radiomics combined with machine learning could predict histology-based steatosis severity in nonhuman primates. By identifying a radiomic signature of hepatic steatosis, our findings demonstrate the translational potential of this approach for non-invasive and objective diagnosis in humans. View this paper
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Articles (131)

  • Article
  • Open Access
898 Views
22 Pages

A Comparative Evaluation of Meta-Learning Models for Few-Shot Chest X-Ray Disease Classification

  • Luis-Carlos Quiñonez-Baca,
  • Graciela Ramirez-Alonso,
  • Fernando Gaxiola,
  • Alain Manzo-Martinez,
  • Raymundo Cornejo and
  • David R. Lopez-Flores

21 September 2025

Background/Objectives: The limited availability of labeled data, particularly in the medical domain, poses a significant challenge for training accurate diagnostic models. While deep learning techniques have demonstrated notable efficacy in image-bas...

  • Article
  • Open Access
604 Views
13 Pages

21 September 2025

Background/Objectives: Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome, characterized by recurrent fever attacks and serositis. Galectin-3, a β-galactoside-binding lectin involved in inflammation and fi...

  • Article
  • Open Access
684 Views
11 Pages

A Novel Virtual Reality-Based System for Measuring Deviation Angle in Strabismus: A Prospective Study

  • Jhih-Yi Lu,
  • Yin-Cheng Liu,
  • Jui-Bang Lu,
  • Ming-Han Tsai,
  • Wen-Ling Liao,
  • I-Ming Wang,
  • Hui-Ju Lin and
  • Yu-Te Huang

20 September 2025

Background/Objectives: To develop a new Virtual Reality (VR) system software for measuring ocular deviation in strabismus patients. Methods: This prospective study included subjects with basic-type exotropia (XT) and non-refractive accommodative esot...

  • Article
  • Open Access
679 Views
11 Pages

20 September 2025

Background/Objectives: Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite influenced by diet, has been linked to cardiovascular disease. Endothelial dysfunction, an early sign of vascular damage, is common in hypertension. This study...

  • Article
  • Open Access
626 Views
13 Pages

20 September 2025

Background/Objectives: This study aimed to investigate the association between the position of impacted mandibular third molars and the morphology of the lingual cortical bone using cone beam computed tomography (CBCT), and to determine how impaction...

  • Article
  • Open Access
642 Views
14 Pages

20 September 2025

Objective: To develop and validate a radiomics-based MRI model for prediction of diffuse-type tenosynovial giant cell tumor (D-TGCT), which has higher postoperative recurrence and more aggressive behavior than localized-type (L-TGCT). The study was c...

  • Article
  • Open Access
1,196 Views
17 Pages

Novel Blood Collection Tubes Improve Sample Preservation in a Multicenter Study in Thailand

  • Khundow Moonla,
  • Renu Wiriyaprasit,
  • Napaporn Apiratmateekul,
  • Nam K. Tran and
  • Wanvisa Treebuphachatsakul

20 September 2025

Background: Blood collection tubes (BCTs) are critical in vitro diagnostic devices used in clinical laboratory testing. Innomed tubes are novel BCTs coated with heparin and anti-glycolytic agents (Innomed 1) and clot activators combined with anti-gly...

  • Opinion
  • Open Access
947 Views
11 Pages

The Warm Phase of CRPS Type-1: Is It Time to Review the Budapest Criteria?

  • Gianantonio Saviola,
  • Sergio Rosini,
  • Luigi Molfetta,
  • Luca Dalle Carbonare,
  • Nazzarena Malavolta,
  • Nunzia Di Meglio,
  • Maria Antonietta Mazzei,
  • Maurizio Muratore and
  • Bruno Frediani

20 September 2025

Complex Regional Pain Syndrome (CRPS) type 1 is a painful and disabling localized syndrome with a pathogenesis that is still unclear. The last revised diagnostic criteria for CRPS-1 syndrome were developed in 2012 (the so-called Budapest criteria), b...

  • Interesting Images
  • Open Access
421 Views
4 Pages

20 September 2025

Congenital agenesis of the tensor fascia lata (TFL) muscle is an extremely rare anomaly, with very few reports in the literature and unclear clinical significance. We report the incidental finding of unilateral TFL agenesis in a 25-year-old male phys...

  • Case Report
  • Open Access
845 Views
9 Pages

20 September 2025

Introduction: Pseudoangiomatous stromal hyperplasia (PASH) is a benign breast lesion characterized by stromal myofibroblast proliferation forming slit-like pseudoangiomatous spaces. Although most frequently diagnosed in premenopausal women, it has al...

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Diagnostics - ISSN 2075-4418