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Diagnostics
Special Issues
Pathology and Diagnosis of Neurological Disorders, 2nd Edition
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Pathology and Diagnosis of Neurological Disorders, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1304

Special Issue Editor

Dr. James Yip

E-Mail Website
Guest Editor
Division of Hematopathology, Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 2200 Northern Blvd, Suite 104, Greenvale, NY 11548, USA
Interests: neuroprotection; stroke; gluconeogenesis; NK cells; T cells; CNS neoplasm; hematolymphoid neoplasm; immunopathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurological disorders encompass a broad range of topics in medicine that deal with the study of diseases of the nervous system. This includes the study of the pathology, diagnosis and treatment of disorders that can be broadly classified into those affecting the central nervous system (CNS) and those that affect the peripheral nervous system (PNS). CNS disorders include conditions such as neurodegenerative diseases, brain tumors, infections and traumatic brain injury, while PNS disorders include peripheral neuropathy, myopathy and motor neuron disease.

This Special Issue of Diagnostics seeks to provide the global community with key reviews and original articles from disciplines spanning an array of topics that critically impact the field of neurological disorders, ranging from vascular stroke to malignant neoplasms. Articles in this issue will touch on broad topics, yet offer focused and specific details. Our goal is to address, amongst other aspects, the diagnostic techniques, fundamental mechanisms, molecular pathology and biomarkers, artificial intelligence and innovative treatment options in the field of neurological disorders. Experts in the areas of diagnostics, pathology and therapies will detail current standards, provide data from novel studies and guide future directions that may soon become critical to our understanding of these disorders. We look forward to and welcome your invaluable work for this issue.

Dr. James Yip
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • CNS tumors
  • neurodegenerative diseases
  • traumatic brain injury

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Published Papers (1 paper)

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13 pages, 1838 KiB  
Systematic Review
Antiplatelet Resumption After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis
by Sarah Yahya Alharthi, Sarah Abdulaziz Alsheikh, Dawood Salman Almousa, Saud Samer A. Alsedrah, Nouf Mohammed Alshammari, Mariam Mostafa Elsayed, Rahaf Ali Hamed AlShamrani, Mohammed Ahmed Yaslam Bellahwal, Abdulrahman Alnwiji, Raed A. Albar and Ayman M. A. Mohamed
Diagnostics 2025, 15(14), 1780; https://doi.org/10.3390/diagnostics15141780 - 15 Jul 2025
Viewed by 1183
Abstract
Background: Intracerebral hemorrhage management presents clinicians with a significant therapeutic challenge. Maintaining antiplatelet therapy potentially increases the risk of recurrent bleeding, while discontinuation heightens susceptibility to ischemic stroke, particularly during the critical first month after hemorrhage. In contemporary practice, physicians demonstrate considerable hesitancy [...] Read more.
Background: Intracerebral hemorrhage management presents clinicians with a significant therapeutic challenge. Maintaining antiplatelet therapy potentially increases the risk of recurrent bleeding, while discontinuation heightens susceptibility to ischemic stroke, particularly during the critical first month after hemorrhage. In contemporary practice, physicians demonstrate considerable hesitancy regarding early antiplatelet reinitiation, complicated by the absence of clear evidence-based treatment guidelines. Aim: This meta-analysis assesses the safety of early antiplatelet resumption following ICH. Methods: We conducted a systematic review by searching Web of Science, Scopus, PubMed, and Cochrane Library from inception to April 2025. Articles were independently screened and data extracted by two reviewers who also assessed study quality. The inclusion criteria are enrollment of adults (≥18 years) with imaging-confirmed intracerebral hemorrhage surviving >24 h, comparing early vs. delayed or withheld antiplatelet therapy. Randomized trials underwent separate evaluation using Cochrane’s Risk of Bias. Statistical analysis was performed using R software (version 4.4.2), with categorical outcomes pooled as risk ratios (RRs) with 95% confidence intervals. Statistical significance was established at p < 0.05. The evidence is limited by the availability of few RCTs, variable antiplatelet regiments, male predominance, and other confounding factors. The review was registered in SFO. Results: Our meta-analysis included 10 studies (8 observational, 2 RCTs) with 5554 patients. Early antiplatelet therapy significantly reduced recurrent intracerebral hemorrhage by 46% (RR 0.54, 95% CI 0.37–0.78, p = 0.001). All-cause mortality showed a non-significant difference (RR 0.81, 95% CI 0.65–1.01, p = 0.06). No significant differences were found for ischemic stroke (RR 0.99, 95% CI 0.60–1.63, p = 0.96), major hemorrhagic events (RR 0.75, 95% CI 0.49–1.13, p = 0.17), or ischemic vascular outcomes (RR 0.71, 95% CI 0.49–1.02, p = 0.60). Conclusions: Our meta-analysis reveals that early antiplatelet therapy following intracerebral hemorrhage significantly reduces recurrent hemorrhagic events (46% reduction) without increasing major ischemic or hemorrhagic complications. Full article
(This article belongs to the Special Issue Pathology and Diagnosis of Neurological Disorders, 2nd Edition)
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