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Diagnostics, Volume 10, Issue 6

June 2020 - 94 articles

Cover Story: Blue light cystoscopy is the most recent breakthrough in the diagnostics of bladder cancer, a common cancer with high rates of recurrence. The photodynamic diagnosis technique uses a photosensitizer as an adjunct to white light cystoscopy to enhance in vivo detection of malignant tissues based on their distinctive fluorescence. Although it has improved detection rates, fluorescence-assisted cystoscopy remains invasive and costly. In parallel, a variety of non-invasive tests and microdevices for the detection of urinary biomarkers of bladder cancer have been developed, none of which have yet entered routine clinical use due to unsatisfactory sensitivity. Following a brief description of the current approaches and their limitations, we provide a systematic review of a new niche research aiming to develop a non-invasive adaptation of photodynamic diagnosis. View this paper.
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Articles (94)

  • Review
  • Open Access
197 Citations
37,174 Views
20 Pages

Validated and accurate laboratory testing for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a crucial part of the timely management of Coronavirus Disease 2019 (COVID-19) disease, supporting the clinical decision-making process for...

  • Article
  • Open Access
11 Citations
8,296 Views
13 Pages

Accuracy of a Semi-Quantitative Ultrasound Method to Determine Liver Fat Infiltration in Early Adulthood

  • Camila Ibacahe,
  • Paulina Correa-Burrows,
  • Raquel Burrows,
  • Gladys Barrera,
  • Elissa Kim,
  • Sandra Hirsch,
  • Boris Jofré,
  • Estela Blanco,
  • Sheila Gahagan and
  • Daniel Bunout

An inexpensive and simple method to determine non-alcoholic fatty liver disease (NAFLD) is the abdominal ultrasound, but there are still doubts about its accuracy. We assessed the precision of a semi-quantitative ultrasound method to determine liver...

  • Article
  • Open Access
9 Citations
3,588 Views
12 Pages

Anthropometric Measurements and Frailty in Patients with Liver Diseases

  • Hiroki Nishikawa,
  • Kazunori Yoh,
  • Hirayuki Enomoto,
  • Naoto Ikeda,
  • Nobuhiro Aizawa,
  • Takashi Koriyama,
  • Takashi Nishimura,
  • Shuhei Nishiguchi and
  • Hiroko Iijima

There have been scarce data regarding the relationship between frailty and anthropometry measurements (AMs) in patients with chronic liver diseases (CLDs). We aimed to elucidate the influence of AMs on frailty in CLDs (median age = 66 years, 183 men...

  • Interesting Images
  • Open Access
4 Citations
4,250 Views
3 Pages

We report a case of a 29-year-old male referred to our hospital for endovascular treatment of a left-sided painful varicocele. Standard retrograde embolization via the left renal vein was not possible because of the presence of a left circum-aortic r...

  • Article
  • Open Access
6 Citations
3,967 Views
12 Pages

Within the European Union, Greece has the highest incidence of lung cancer among people under 45 years of age. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are indicated for the treatment of patients with EGFR mutation-positive...

  • Article
  • Open Access
117 Citations
12,668 Views
22 Pages

Development of a Deep Learning Algorithm for Periapical Disease Detection in Dental Radiographs

  • Michael G. Endres,
  • Florian Hillen,
  • Marios Salloumis,
  • Ahmad R. Sedaghat,
  • Stefan M. Niehues,
  • Olivia Quatela,
  • Henning Hanken,
  • Ralf Smeets,
  • Benedicta Beck-Broichsitter and
  • Carsten Rendenbach
  • + 3 authors

Periapical radiolucencies, which can be detected on panoramic radiographs, are one of the most common radiographic findings in dentistry and have a differential diagnosis including infections, granuloma, cysts and tumors. In this study, we seek to in...

  • Article
  • Open Access
28 Citations
4,955 Views
13 Pages

Measuring Spinal Mobility Using an Inertial Measurement Unit System: A Validation Study in Axial Spondyloarthritis

  • I. Concepción Aranda-Valera,
  • Antonio Cuesta-Vargas,
  • Juan L. Garrido-Castro,
  • Philip V. Gardiner,
  • Clementina López-Medina,
  • Pedro M. Machado,
  • Joan Condell,
  • James Connolly,
  • Jonathan M. Williams and
  • Karla Muñoz-Esquivel
  • + 5 authors

Portable inertial measurement units (IMUs) are beginning to be used in human motion analysis. These devices can be useful for the evaluation of spinal mobility in individuals with axial spondyloarthritis (axSpA). The objectives of this study were to...

  • Review
  • Open Access
6 Citations
4,505 Views
13 Pages

Ultrasonic cerebral tomosphygmography (UCTS), also known as “encephaloscan”, is an ultrasound-based pulsatile echoencephalography for both functional and anatomical brain imaging investigations. Compared to classical imaging, UCTS makes i...

  • Article
  • Open Access
16 Citations
4,321 Views
13 Pages

The Limulus amebocyte assay (LAL) is increasingly used to quantify metabolic endotoxemia (ME), particularly in feeding studies. However, the assay was not intended to assess plasma at levels typically seen in ME. We aimed to optimize and validate the...

  • Article
  • Open Access
4 Citations
3,541 Views
18 Pages

Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J

  • Andrés Fernández-Vega Cueto,
  • Lydia Álvarez,
  • Montserrat García,
  • Enol Artime,
  • Ana Álvarez Barrios,
  • Ignacio Rodríguez-Uña,
  • Miguel Coca-Prados and
  • Héctor González-Iglesias

Animal models of glaucoma, a neurodegenerative disease affecting the retina, offer the opportunity to study candidate molecular biomarkers throughout the disease. In this work, the DBA/2J glaucomatous mouse has been used to study the systemic levels...

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Diagnostics - ISSN 2075-4418