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Genes, Volume 14, Issue 7

July 2023 - 206 articles

Cover Story: RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has been observed in many human pathologies, ranging from neurodegenerative diseases to cancer. The recent identification of recurrent mutations in the core components of the spliceosome in hematologic malignancies has advanced our knowledge of how splicing alterations contribute to disease pathogenesis. This review article will discuss our current understanding of how aberrant RNA splicing regulation drives tumor initiation and progression. We will also review current therapeutic modalities and highlight emerging technologies designed to target RNA splicing for cancer treatment. View this paper
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Articles (206)

  • Article
  • Open Access
4 Citations
2,870 Views
14 Pages

The Genetic Diversity of Stallions of Different Breeds in Russia

  • Natalia Dementieva,
  • Elena Nikitkina,
  • Yuri Shcherbakov,
  • Olga Nikolaeva,
  • Olga Mitrofanova,
  • Anna Ryabova,
  • Mikhail Atroshchenko,
  • Oksana Makhmutova and
  • Alexander Zaitsev

24 July 2023

The specifics of breeding and selection significantly affect genetic diversity and variability within a breed. We present the data obtained from the genetic analysis of 21 thoroughbred and warmblood horse breeds. The most detailed information is desc...

  • Article
  • Open Access
1 Citations
2,029 Views
11 Pages

24 July 2023

Complete mitochondrial genomes were newly sequenced for eight species of the treehopper subfamily Centrotinae (Hemiptera: Membracidae), four of which represent genera for which mitogenomes were not previously available. The new mitogenomes are genera...

  • Article
  • Open Access
2 Citations
1,753 Views
11 Pages

Evidence for Two Soybean Looper Strains in the United States with Limited Capacity for Cross-Hybridization

  • Rodney N. Nagoshi,
  • Jeffrey A. Davis,
  • Robert L. Meagher,
  • Fred R. Musser,
  • Graham P. Head,
  • Hector Portillo and
  • Henry Teran

24 July 2023

The noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker) is an economically important pest of soybeans (Glycine max (L.) Merr.) in the southeastern United States. It has characteristics that are of particular concern for pest mitigation...

  • Article
  • Open Access
9 Citations
3,013 Views
14 Pages

24 July 2023

Larimichthys crocea (also known as the large yellow croaker) is one of the most economically important marine fishes in China, and research on the ecology and genetics of this species is of immense significance. In this study, we performed restrictio...

  • Article
  • Open Access
3 Citations
3,338 Views
37 Pages

GWAS for Early-Establishment QTLs and Their Linkage to Major Phenology-Affecting Genes (Vrn, Ppd, and Eps) in Bread Wheat

  • Md. Farhad,
  • Shashi B. Tripathi,
  • Ravi P. Singh,
  • Arun K. Joshi,
  • Pradeep K. Bhati,
  • Manish K. Vishwakarma and
  • Uttam Kumar

24 July 2023

Farmers in northern and central Indian regions prefer to plant wheat early in the season to take advantage of the remaining soil moisture. By planting crops before the start of the season, it is possible to extend the time frame for spring wheat. The...

  • Review
  • Open Access
16 Citations
5,524 Views
24 Pages

Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations

  • Shabnam Nohesara,
  • Hamid Mostafavi Abdolmaleky and
  • Sam Thiagalingam

24 July 2023

Nutrition and metabolism modify epigenetic signatures like histone acetylation and DNA methylation. Histone acetylation and DNA methylation in the central nervous system (CNS) can be altered by bioactive nutrients and gut microbiome via the gut–brain...

  • Article
  • Open Access
7 Citations
2,874 Views
17 Pages

APC-Related Phenotypes and Intellectual Disability in 5q Interstitial Deletions: A New Case and Review of the Literature

  • Flavia Privitera,
  • Flavia Piccini,
  • Maria Paola Recalcati,
  • Silvia Presi,
  • Silvia Mazzola and
  • Paola Carrera

23 July 2023

The 5q deletion syndrome is a relatively rare condition caused by the monoallelic interstitial deletion of the long arm of chromosome 5. Patients described in literature usually present variable dysmorphic features, behavioral disturbance, and intell...

  • Article
  • Open Access
3,047 Views
18 Pages

Drosophila as Model System to Study Ras-Mediated Oncogenesis: The Case of the Tensin Family of Proteins

  • Ana Martínez-Abarca Millán,
  • Jennifer Soler Beatty,
  • Andrea Valencia Expósito and
  • María D. Martín-Bermudo

23 July 2023

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, tissue growth induced by oncogenic Ras is restrained by the induction of cellular senescence, and additional mutations are required to induce tumor progression....

  • Article
  • Open Access
4 Citations
2,763 Views
16 Pages

The Ratio of cf-mtDNA vs. cf-nDNA in the Follicular Fluid of Women Undergoing IVF Is Positively Correlated with Age

  • Georgia Tsirka,
  • Athanasios Zikopoulos,
  • Kyriaki Papageorgiou,
  • Charilaos Kostoulas,
  • Ioannis Tsigkas,
  • Efthalia Moustakli,
  • Aris Kaltsas,
  • Eleftheria Sarafi,
  • Theologos M. Michaelidis and
  • Ioannis Georgiou

23 July 2023

Age-related mitochondrial markers may facilitate the prognosis of artificial reproductive technology outcomes. In this report, we present our study concerning the ratio of cf-mtDNA/cf-nDNA, namely the amount of cell-free mitochondrial DNA relative to...

  • Communication
  • Open Access
9 Citations
2,117 Views
10 Pages

Identification of ROH Islands Conserved through Generations in Pigs Belonging to the Nero Lucano Breed

  • Paola Di Gregorio,
  • Annamaria Perna,
  • Adriana Di Trana and
  • Andrea Rando

23 July 2023

The recovery of Nero Lucano (NL) pigs in the Basilicata region (Southern Italy) started in 2001 with the collaboration of several public authorities in order to preserve native breeds that can play a significant economic role both due to their remark...

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Genes - ISSN 2073-4425