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Genes, Volume 14, Issue 7

July 2023 - 206 articles

Cover Story: RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has been observed in many human pathologies, ranging from neurodegenerative diseases to cancer. The recent identification of recurrent mutations in the core components of the spliceosome in hematologic malignancies has advanced our knowledge of how splicing alterations contribute to disease pathogenesis. This review article will discuss our current understanding of how aberrant RNA splicing regulation drives tumor initiation and progression. We will also review current therapeutic modalities and highlight emerging technologies designed to target RNA splicing for cancer treatment. View this paper
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Articles (206)

  • Article
  • Open Access
6 Citations
3,128 Views
25 Pages

22 July 2023

ParaHox genes are key developmental regulators involved in the patterning of the digestive tract along the anteroposterior axis and the development of the nervous system. Most studies have focused on the function of these genes in embryogenesis, whil...

  • Article
  • Open Access
7 Citations
2,313 Views
18 Pages

22 July 2023

Background: The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. However, the spatial patterns of MHC variation in the striped hamster remain unclear, particul...

  • Article
  • Open Access
6 Citations
2,336 Views
18 Pages

22 July 2023

To further understand the origin and evolution of Palaemonidae (Decapoda: Caridea), we determined the mitochondrial genome sequence of Palaemon macrodactylus and Palaemon tenuidactylus. The entire mitochondrial genome sequences of these two Pala...

  • Article
  • Open Access
2 Citations
2,800 Views
16 Pages

Evolutionary Rates, Divergence Rates, and Performance of Individual Mitochondrial Genes Based on Phylogenetic Analysis of Copepoda

  • Junzong He,
  • Zhihao Zhou,
  • Yan Huang,
  • Jinmei Feng,
  • Wenxiang Li,
  • Guitang Wang and
  • Congjie Hua

22 July 2023

Copepoda is a large and diverse group of crustaceans, which is widely distributed worldwide. It encompasses roughly 9 orders, whose phylogeny remains unresolved. We sequenced the complete mitochondrial genome (mitogenome) of Sinergasilus major (Marke...

  • Article
  • Open Access
5 Citations
1,985 Views
11 Pages

Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells

  • Jinkui Sun,
  • Yong Ruan,
  • Jiali Xu,
  • Pengfei Shi and
  • Houqiang Xu

22 July 2023

Myocyte enhancer factor 2A (MEF2A) is a member of the myocyte enhancer factor 2 family. MEF2A is widely distributed in various tissues and organs and participates in various physiological processes. This study aimed to investigate the effect of MEF2A...

  • Article
  • Open Access
2,194 Views
16 Pages

Genetic Ancestry Estimates within Dutch Family Units and Across Genotyping Arrays: Insights from Empirical Analysis Using Two Estimation Methods

  • Jeffrey J. Beck,
  • Talitha Ahmed,
  • Casey T. Finnicum,
  • Koos Zwinderman,
  • Erik A. Ehli,
  • Dorret I. Boomsma and
  • Jouke Jan Hottenga

22 July 2023

Accurate inference of genetic ancestry is crucial for population-based association studies, accounting for population heterogeneity and structure. This study analyzes genome-wide SNP data from the Netherlands Twin Register to compare genetic ancestry...

  • Article
  • Open Access
2 Citations
2,264 Views
14 Pages

22 July 2023

The Noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker), is an economically important pest of soybean (Glycine max (Linnaeus) Merrill). Because it is not known to survive freezing winters, permanent populations in the United States are...

  • Article
  • Open Access
1 Citations
2,750 Views
15 Pages

22 July 2023

The Indian highland shrew, Suncus niger (Horsfield, 1851), is the least studied soricid species from its original range distribution in Southern India, with several systematics conundrums. Following its discovery in 1851, the species was synonymized...

  • Brief Report
  • Open Access
1,844 Views
8 Pages

Integration of Phenotype Term Prioritization and Gene Expression Analysis Reveals a Novel Variant in the PERP Gene Associated with Autosomal Recessive Erythrokeratoderma

  • Adrián González-Quintana,
  • Rocío Garrido-Moraga,
  • Sara I. Palencia-Pérez,
  • Ángela Hernández-Martín,
  • Jon Sánchez-Munárriz,
  • José M. Lezana-Rosales,
  • Juan F. Quesada-Espinosa,
  • Miguel A. Martín and
  • Ana Arteche-López

22 July 2023

Hereditary palmoplantar keratodermas (PPKs) are a clinically and genetically heterogeneous group of disorders characterized by excessive epidermal thickening of palms and soles. Several genes have been associated with PPK including PERP, a gene encod...

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Genes - ISSN 2073-4425