Table of Contents
Cells, Volume 8, Issue 10 (October 2019)
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Cover Story (view full-size image) Hepatitis C virus (HCV) infection in human often causes liver fibrosis, although the virus does not [...] Read more. Hepatitis C virus (HCV) infection in human often causes liver fibrosis, although the virus does not replicate in hepatic stellate cells. Exosomes carry different biomolecules as cargo, including soluble and membrane-bound proteins, lipids, and nucleic acids. HCV-infected hepatocytes secrete exosomes for intercellular communication and play a role in the induction of liver fibrosis. Exosomes are easily uptaken by quiescent hepatic stellate cells. The exposure of biomolecules from internalized exosomes promotes activation of quiescent hepatic stellate cells which, in turn, leads to fibrosis. Other mechanisms also play an important role in establishing liver fibrosis. View this paper.