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Open AccessArticle

Dental Epithelial Stem Cells as a Source for Mammary Gland Regeneration and Milk Producing Cells In Vivo

1
Department of Orofacial Development and Regeneration, Institute of Oral Biology, Centre for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland
2
Division of Developmental Biology and Regenerative Medicine, Department of Anatomy, Iwate Medical University Yahaba, Morioka 020-0023, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(10), 1302; https://doi.org/10.3390/cells8101302
Received: 17 September 2019 / Revised: 17 October 2019 / Accepted: 18 October 2019 / Published: 22 October 2019
(This article belongs to the Special Issue Stem Cell Therapy in Oral and Maxillofacial Region)
The continuous growth of rodent incisors is ensured by clusters of mesenchymal and epithelial stem cells that are located at the posterior part of these teeth. Genetic lineage tracing studies have shown that dental epithelial stem cells (DESCs) are able to generate all epithelial cell populations within incisors during homeostasis. However, it remains unclear whether these cells have the ability to adopt alternative fates in response to extrinsic factors. Here, we have studied the plasticity of DESCs in the context of mammary gland regeneration. Transplantation of DESCs together with mammary epithelial cells into the mammary stroma resulted in the formation of chimeric ductal epithelial structures in which DESCs adopted all the possible mammary fates including milk-producing alveolar cells. In addition, when transplanted without mammary epithelial cells, DESCs developed branching rudiments and cysts. These in vivo findings demonstrate that when outside their niche, DESCs redirect their fates according to their new microenvironment and thus can contribute to the regeneration of non-dental tissues. View Full-Text
Keywords: dental epithelial stem cells; mammary gland; tooth; tissue regeneration; rodent incisor; plasticity dental epithelial stem cells; mammary gland; tooth; tissue regeneration; rodent incisor; plasticity
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MDPI and ACS Style

Jimenez-Rojo, L.; Pagella, P.; Harada, H.; Mitsiadis, T.A. Dental Epithelial Stem Cells as a Source for Mammary Gland Regeneration and Milk Producing Cells In Vivo. Cells 2019, 8, 1302.

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