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Article

Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin

1
Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City 15462, Kuwait
2
Department of Genetic and Bioinformatics, Dasman Diabetes Institute, Kuwait City 15462, Kuwait
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Department of Surgery, Faculty of Medicine, Health Sciences Centre, Kuwait University, Sulaibekhat 90805, Kuwait
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Department of Pharmacology & Toxicology, Faculty of Medicine, Health Sciences Centre, Kuwait University, Sulaibekhat 90805, Kuwait
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Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Health Sciences Centre, Kuwait University, Sulaibekhat 90805, Kuwait
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Research Division, Dasman Diabetes Institute, Kuwait City 15462, Kuwait
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(10), 1283; https://doi.org/10.3390/cells8101283
Received: 24 August 2019 / Revised: 30 September 2019 / Accepted: 1 October 2019 / Published: 19 October 2019
(This article belongs to the Special Issue Adipocytes and Metabolic Health)
Type 2 diabetes (T2D) is a growing pandemic associated with metabolic dysregulation and chronic inflammation. Meteorin-like hormone (METRNL) is an adipomyokine that is linked to T2D. Our objective was to evaluate the changes in METRNL levels in T2D and obesity and assess the association of METRNL levels with irisin. Overall, 228 Arab individuals were enrolled. Plasma levels of METRNL and irisin were assessed using immunoassay. Plasma levels of METRNL and irisin were significantly higher in T2D patients than in non-diabetic patients (p < 0.05). When the population was stratified based on obesity, METRNL and irisin levels were significantly higher in obese than in non-obese individuals (p < 0.05). We found a significant positive correlation between METRNL and irisin (r = 0.233 and p = 0.001). Additionally, METRNL and irisin showed significant correlation with various metabolic biomarkers associated with T2D and Obesity. Our data shows elevated METRNL plasma levels in individuals with T2D, further exacerbated with obesity. Additionally, a strong positive association was observed between METRNL and irisin. Further studies are necessary to examine the role of these proteins in T2D and obesity, against their ethnic background and to understand the mechanistic significance of their possible interplay. View Full-Text
Keywords: Meteorin-like hormone; METRNL; irisin; adipomyokines; type 2 diabetes; obesity Meteorin-like hormone; METRNL; irisin; adipomyokines; type 2 diabetes; obesity
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MDPI and ACS Style

AlKhairi, I.; Cherian, P.; Abu-Farha, M.; Madhoun, A.A.; Nizam, R.; Melhem, M.; Jamal, M.; Al-Sabah, S.; Ali, H.; Tuomilehto, J.; Al-Mulla, F.; Abubaker, J. Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin. Cells 2019, 8, 1283. https://doi.org/10.3390/cells8101283

AMA Style

AlKhairi I, Cherian P, Abu-Farha M, Madhoun AA, Nizam R, Melhem M, Jamal M, Al-Sabah S, Ali H, Tuomilehto J, Al-Mulla F, Abubaker J. Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin. Cells. 2019; 8(10):1283. https://doi.org/10.3390/cells8101283

Chicago/Turabian Style

AlKhairi, Irina, Preethi Cherian, Mohamed Abu-Farha, Ashraf A. Madhoun, Rasheeba Nizam, Motasem Melhem, Mohamed Jamal, Suleiman Al-Sabah, Hamad Ali, Jaakko Tuomilehto, Fahd Al-Mulla, and Jehad Abubaker. 2019. "Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin" Cells 8, no. 10: 1283. https://doi.org/10.3390/cells8101283

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