Next Article in Journal
Mechanisms Underlying Hepatitis C Virus-Associated Hepatic Fibrosis
Next Article in Special Issue
Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia
Previous Article in Journal
The Role of Adenine Nucleotide Translocase in the Assembly of Respiratory Supercomplexes in Cardiac Cells
Previous Article in Special Issue
“Hierarchy” and “Holacracy”; A Paradigm of the Hematopoietic System
Open AccessReview

Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy

Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano (Turin), Italy
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(10), 1248; https://doi.org/10.3390/cells8101248
Received: 25 September 2019 / Revised: 10 October 2019 / Accepted: 11 October 2019 / Published: 14 October 2019
(This article belongs to the Special Issue Hematopoiesis and Stem Cells)
Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis and sensitivity to therapies. In this review, we will recapitulate the role of various shuttling components in Chronic Myeloid Leukemia and we will provide insights on the potential role of shuttling proteins as therapeutic targets. View Full-Text
Keywords: nuclear-cytoplasmic shuttling; chronic myeloid leukemia; BCR-ABL; miRNA; PTEN; p53 nuclear-cytoplasmic shuttling; chronic myeloid leukemia; BCR-ABL; miRNA; PTEN; p53
MDPI and ACS Style

Carrà, G.; Russo, I.; Guerrasio, A.; Morotti, A. Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy. Cells 2019, 8, 1248.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop