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Cancers, Volume 11, Issue 10 (October 2019)
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Cover Story (view full-size image) Despite advancements in therapy, the development of castrate resistance in prostate cancer (PCa) [...] Read more. Despite advancements in therapy, the development of castrate resistance in prostate cancer (PCa) remains a major clinical hurdle. An emerging and increasingly appreciated impediment in the treatment of advanced PCa is the development of neuroendocrine differentiation (NED), also known as treatment-induced neuroendocrine prostate cancer (t-NEPC) that is aggressive and lacks therapeutic approaches. It is believed that androgen deprivation therapy may be a predominant mediator in the development of the t-NEPC phenotype. Intriguingly, although classical NEPC is rare in the clinic, it is estimated that ~30% of PCa patients develop t-NEPC. It is therefore crucial to identify the molecular and cellular mechanisms, including the role of tumor microenvironment (TME) that orchestrates t-NEPC, with the goal of developing novel and specific treatment modalities against this aggressive form of the disease. View this paper