Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy
1
Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, China
2
Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
3
Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 44000, Pakistan
*
Authors to whom correspondence should be addressed.
Cancers 2019, 11(10), 1592; https://doi.org/10.3390/cancers11101592
Received: 28 September 2019
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Revised: 13 October 2019
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Accepted: 14 October 2019
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Published: 18 October 2019
(This article belongs to the Special Issue Targeting Therapy for Colon Cancer)
Colorectal patients generally have the maximum counts of Fusobacterium nucleatum (F. nucleatum) in tumors and elevate colorectal adenomas and carcinomas, which show the lowest rate of human survival. Hence, F. nucleatum is a diagnostic marker of colorectal cancer (CRC). Studies demonstrated that targeting fusobacterial Fap2 or polysaccharide of the host epithelium may decrease fusobacteria count in the CRC. Attenuated F. nucleatum-Fap2 prevents transmembrane signals and inhibits tumorigenesis inducing mechanisms. Hence, in this review, we hypothesized that application of genetically programmed fusobacterium can be skillful and thus reduce fusobacterium in the CRC. Genetically programmed F. nucleatum is a promising antitumor strategy.
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Keywords:
Fusobacterium nucleatum; CRC; genetically programmed; cancer therapy
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MDPI and ACS Style
Ganesan, K.; Guo, S.; Fayyaz, S.; Zhang, G.; Xu, B. Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy. Cancers 2019, 11, 1592. https://doi.org/10.3390/cancers11101592
AMA Style
Ganesan K, Guo S, Fayyaz S, Zhang G, Xu B. Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy. Cancers. 2019; 11(10):1592. https://doi.org/10.3390/cancers11101592
Chicago/Turabian StyleGanesan, Kumar, Songhe Guo, Sundaz Fayyaz, Ge Zhang, and Baojun Xu. 2019. "Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy" Cancers 11, no. 10: 1592. https://doi.org/10.3390/cancers11101592
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