Tumor Metabolome: Therapeutic Opportunities Targeting Cancer Metabolic Reprogramming

Dear Colleagues,

Cancer cells have metabolic requirements that separate them from normal cells and render them vulnerable to drugs that target these processes. The altered metabolism exhibited by most tumor cells is a hallmark of cancer. Pioneering works studying the differential metabolic traits of cancer cells firstly classified tumors as glucose and nitrogen traps, thus reflecting their ability to avidly consume both nutrients. In recent years, metabolic studies using omics technologies are more precisely unveiling the tumor metabolome and cancer-specific metabolomic signatures.

Despite the sound advances in knowledge and the rapid progress in the field of cancer metabolic reprogramming, this information needs to be translated into a more successful class of cancer therapeutic strategies. Furthermore, the mechanims that control the metabolic phenotype of specific tumors have not been fully understood, and the biological functions of many cancer-relevant proteins have yet to be explored. These issues need to be addressed in order to improve drug design and to overcome the drug resistance phenomenon frequently found in cancer therapy. In this Special Issue of Cancers, we aim to stimulate discussions on these topics, whilst allowing an updated account of relevant works on the tumor metabolome by bringing together expert opinions from across the field. We welcome submissions that cover any relevant topic, including metabolite addiction in cancer cells, cancer metabolic rewiring, cancer metabolic remodelling by tumor-specific isoenzymes, cancer-specific bionergetic alterations, new metabolic functions of tumor suppresor genes and oncogenes, mechanisms of metabolic dysregulation in cancers, and new therapeutic approaches targeting cancer metabolism.

Prof. Dr. Javier Marquez
Prof. Dr. José M. Matés
Guest Editors

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