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Open AccessReview

Productive Cross-Talk with the Microenvironment: A Critical Step in Ovarian Cancer Metastasis

1
Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47405, USA
2
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
3
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(10), 1608; https://doi.org/10.3390/cancers11101608
Received: 3 September 2019 / Revised: 4 October 2019 / Accepted: 14 October 2019 / Published: 21 October 2019
(This article belongs to the Special Issue Ovarian Cancer Metastasis)
Most ovarian cancer patients present with disseminated disease at the time of their diagnosis, which is one of the main reasons for their poor prognosis. Metastasis is a multi-step process and a clear understanding of the mechanism of regulation of these steps remains elusive. Productive reciprocal interactions between the metastasizing ovarian cancer cells and the microenvironment of the metastatic site or the tumor microenvironment play an important role in the successful establishment of metastasis. Much progress has been made in the recent past in our understanding of such interactions and the role of the cellular and acellular components of the microenvironment in establishing the metastatic tumors. This review will outline the role of the microenvironmental components of the ovarian cancer metastatic niche and their role in helping establish the metastatic tumors. Special emphasis will be given to the mesothelial cells, which are the first cells encountered by the cancer cells at the site of metastasis. View Full-Text
Keywords: ovarian cancer; microenvironment; metastasis; mesothelial cells; fibroblasts; adipocytes; cross-talk; ECM ovarian cancer; microenvironment; metastasis; mesothelial cells; fibroblasts; adipocytes; cross-talk; ECM
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Abd El Aziz, M.A.; Agarwal, K.; Dasari, S.; Mitra, A.K. Productive Cross-Talk with the Microenvironment: A Critical Step in Ovarian Cancer Metastasis. Cancers 2019, 11, 1608.

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